Heartburn: impact on physical activity level

Oliver, Katie L.; Davies, G. J.; Dettmar, Peter W.

doi:10.1017/s0029665109992497

Cited by 1 publication

(1 citation statement)

References 3 publications

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“…[48,49] This obesity-induced inflammation is widely recognized to play a causative role in the development of insulin resistance and T2DM. [8,50] There is a considerable amount of evidence regarding the contribution of fish oils or omega-3 fatty acids to diseases with inflammatory conditions, such as atherosclerosis, inflammatory bowel disease, rheumatoid arthritis, and metabolic syndromes. [20,21] The anti-inflammatory effect of omega-3 fatty acids is likely involved in the improvement of insulin sensitivity and the prevention of metabolic syndrome or T2DM development, [20] although an improvement in adiposity has also been attributed to the omega-3 fatty acid-associated effects.…”

Section: Effects Of Omega-3 Fatty Acids On Obesity-induced Inflammationmentioning

confidence: 99%

Immuno‐Resolving Ability of Resolvins, Protectins, and Maresins Derived from Omega‐3 Fatty Acids in Metabolic Syndrome

Kwon

2019

Molecular Nutrition Food Res

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Omega‐3 fatty acid consumption has been suggested to be beneficial for the prevention of type 2 diabetes mellitus (T2DM). Its effects have been attributed to anti‐inflammatory activity, with the inhibition of arachidonic acid metabolism playing a central role. However, a more recent view is that omega‐3 fatty acids play an active role as the precursors of potent, specialized pro‐resolving mediators (SPMs), such as resolvins, protectins, and maresins. Docosahexaenoic acid (DHA)‐ and eicosapentaenoic‐acid‐derived SPMs are identified in the adipose tissue but the levels of certain SPMs (e.g., protectin D1) are markedly reduced with obesity, suggesting adipose SPM deficiency, potentially resulting in unresolved inflammation. Supplementation of the biosynthetic intermediates of SPM (e.g., 17‐hydroxy‐DHA) or omega‐3 fatty acids increases the level of adipose SPMs, reduces adipose inflammation (decrease in macrophage accumulation and change to less inflammatory macrophages), and enhances insulin sensitivity. The findings from studies using rodent obesity models must be translated to humans. It will be important to further elucidate the underlying mechanisms by which obesity reduces the levels of and the sensitivity to SPM in adipose tissues. This will enable the development of nutrition therapy to enhance the effects of omega‐3 fatty acids in the prevention and/or treatment of T2DM.

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Section: Effects Of Omega-3 Fatty Acids On Obesity-induced Inflammationmentioning

confidence: 99%

Immuno‐Resolving Ability of Resolvins, Protectins, and Maresins Derived from Omega‐3 Fatty Acids in Metabolic Syndrome

Kwon

2019

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

Heartburn: impact on physical activity level

Cited by 1 publication

References 3 publications

Immuno‐Resolving Ability of Resolvins, Protectins, and Maresins Derived from Omega‐3 Fatty Acids in Metabolic Syndrome

Immuno‐Resolving Ability of Resolvins, Protectins, and Maresins Derived from Omega‐3 Fatty Acids in Metabolic Syndrome

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