2021
DOI: 10.1007/s00408-021-00496-w
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Heartburn as a Marker of the Success of Acid Suppression Therapy in Chronic Cough

Abstract: Purpose Gastro-oesophageal reflux disease (GORD) is commonly thought to play an important role in chronic cough and patients are often empirically treated with acid suppression therapy. We sought to investigate the response rate to acid suppression treatment in patients with and without heartburn attending two specialist cough clinics. Methods A retrospective review of 558 consecutive patients referred to two specialist cough clinics was performed … Show more

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Cited by 10 publications
(6 citation statements)
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“…Small RCTs of acid-suppressing therapy (PPIs and H 2 receptor blockers) in patients with chronic cough have been performed but did not report positive results; a pooled analysis of these data suggests that adults with acid reflux on 24 h pH monitoring or symptoms of heartburn are most likely to experience benefit, which is now reflected in clinical guidelines 4 , 141 , 153 . Observational data support this approach, but response rates were low (28%) even in patients with chronic cough who reported heartburn 154 . Treatments for non-acid reflux are limited.…”
Section: Managementmentioning
confidence: 99%
“…Small RCTs of acid-suppressing therapy (PPIs and H 2 receptor blockers) in patients with chronic cough have been performed but did not report positive results; a pooled analysis of these data suggests that adults with acid reflux on 24 h pH monitoring or symptoms of heartburn are most likely to experience benefit, which is now reflected in clinical guidelines 4 , 141 , 153 . Observational data support this approach, but response rates were low (28%) even in patients with chronic cough who reported heartburn 154 . Treatments for non-acid reflux are limited.…”
Section: Managementmentioning
confidence: 99%
“…A pooled analysis of these data suggests that adults with acid reflux on 24h pH monitoring or symptoms of heartburn are most likely to experience benefit, which is now reflected in clinical guidelines 4, 144,155 . Observational data supports this approach, but response rates were low (28%) even in chronic cough patients complaining of heartburn 156 . Treatments for non-acid reflux are limited.…”
Section: [H3] Asthmamentioning
confidence: 95%
“…Физиологические уровни рефлюкса могут стимулировать эпизоды кашля [66]. Лечение ингибиторами протонной помпы (ИПП) эффективно только в том случае, если у пациента есть изжога или другие явные признаки кислотного рефлюкса, например, регургитация, боль или дискомфорт в верхней части живота/груди [67][68][69].…”
Section: гастроэзофагеальная рефлюксная болезньunclassified