Heartbeat evoked potentials (HEP): topography and influence of cardiac awareness and focus of attention

Montoya, Pedro; Schandry, Rainer; Müller, Andreas Michael

doi:10.1016/0168-5597(93)90001-6

Cited by 197 publications

(198 citation statements)

References 18 publications

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“…Our work is predicated on studies describing afferent ''interoceptive'' potentials triggered on the heart (17)(18)(19)(20)29). However, in contrast to previous findings, our research represents a demonstration of cortically recorded indices of cardiac function in a clinical population.…”

Section: Discussionmentioning

confidence: 72%

“…Electroencephalography (EEG) has higher temporal resolution than techniques such as positron emission tomography or functional MRI (fMRI), although is limited with respect to inferring neuroanatomical generators of surface potentials. EEG methods have been applied to the study of afferent cardiac signals, where a heartbeat-evoked potential (HEP) has been described (17)(18)(19)(20). The circumscribed location of this HEP to frontal and central scalp (17,18,21,22) and particularly the observation that its amplitude predicts individual differences in interoceptive awareness (accuracy of heartbeat perception) (19) is consistent with a cardiac afferent source, arising from myocardial, carotid sinus and/or aortic arch baroreceptors, or perhaps mechanoreceptors within tissue distended by ejected blood (23)(24)(25).…”

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confidence: 99%

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A cortical potential reflecting cardiac function

Gray

Taggart

Sutton

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

187

132

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Emotional trauma and psychological stress can precipitate cardiac arrhythmia and sudden death through arrhythmogenic effects of efferent sympathetic drive. Patients with preexisting heart disease are particularly at risk. Moreover, generation of proarrhythmic activity patterns within cerebral autonomic centers may be amplified by afferent feedback from a dysfunctional myocardium. An electrocortical potential reflecting afferent cardiac information has been described, reflecting individual differences in interoceptive sensitivity (awareness of one's own heartbeats). To inform our understanding of mechanisms underlying arrhythmogenesis, we extended this approach, identifying electrocortical potentials corresponding to the cortical expression of afferent information about the integrity of myocardial function during stress. We measured changes in cardiac response simultaneously with electroencephalography in patients with established ventricular dysfunction. Experimentally induced mental stress enhanced cardiovascular indices of sympathetic activity (systolic blood pressure, heart rate, ventricular ejection fraction, and skin conductance) across all patients. However, the functional response of the myocardium varied; some patients increased, whereas others decreased, cardiac output during stress. Across patients, heartbeat-evoked potential amplitude at left temporal and lateral frontal electrode locations correlated with stress-induced changes in cardiac output, consistent with an afferent cortical representation of myocardial function during stress. Moreover, the amplitude of the heartbeat-evoked potential in the left temporal region reflected the proarrhythmic status of the heart (inhomogeneity of left ventricular repolarization). These observations delineate a cortical representation of cardiac function predictive of proarrhythmic abnormalities in cardiac repolarization. Our findings highlight the dynamic interaction of heart and brain in stress-induced cardiovascular morbidity. afferent homeostatic feedback ͉ electroencephalography ͉ heart beat-evoked potential ͉ insula cortex ͉ ischemia

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Section: Discussionmentioning

confidence: 72%

mentioning

confidence: 99%

A cortical potential reflecting cardiac function

Gray

Taggart

Sutton

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

187

132

View full text Add to dashboard Cite

show abstract

“…The amplitude of the HER is modulated by heartbeats' task-relevance [49], and the modulation is all the more pronounced when subjects have been trained to perceive cardiac information [50] and are motivated [39]. HER amplitude in the heartbeat perception task is a good predictor of subjects' explicit interoceptive abilities: HER amplitude is larger in good heartbeat perceivers compared with bad heartbeat perceivers [51], and HER amplitude is decreased in depressed patients who showed less accurate heartbeat perception than normal controls [52].…”

Section: The Biological Basis Of the Subjective Framementioning

confidence: 99%

The neural subjective frame: from bodily signals to perceptual consciousness

Park

Tallon‐Baudry

2014

Phil. Trans. R. Soc. B

182

138

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The report ‘I saw the stimulus’ operationally defines visual consciousness, but where does the ‘I’ come from? To account for the subjective dimension of perceptual experience, we introduce the concept of the neural subjective frame. The neural subjective frame would be based on the constantly updated neural maps of the internal state of the body and constitute a neural referential from which first person experience can be created. We propose to root the neural subjective frame in the neural representation of visceral information which is transmitted through multiple anatomical pathways to a number of target sites, including posterior insula, ventral anterior cingulate cortex, amygdala and somatosensory cortex. We review existing experimental evidence showing that the processing of external stimuli can interact with visceral function. The neural subjective frame is a low-level building block of subjective experience which is not explicitly experienced by itself which is necessary but not sufficient for perceptual experience. It could also underlie other types of subjective experiences such as self-consciousness and emotional feelings. Because the neural subjective frame is tightly linked to homeostatic regulations involved in vigilance, it could also make a link between state and content consciousness.

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“…It is well established that the cardiovascular system possesses afferents to the prefrontal cortex (see e.g. Montoya et al, 1993). Therefore, it seems reasonable to speculate that cardiovascular input may modulate higher-order prefrontal functions.…”

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confidence: 99%

Early contingent negative variation of the EEG and attentional flexibility are reduced in hypotension

Weisz¹,

Schandry²,

Jacobs³

et al. 2002

International Journal of Psychophysiology

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This study explored the question as to whether hypotension is related to decreased attentional performance and reduced cortical activation. A total of 50 females aged 19-44 years participated in the study. Attentional performance was assessed using three subtests of the Attentional and Cognitive Efficiency (ACE) battery. Contingent negative variation (CNV) as a measure of cortical activation was registered during a constant fore-period reaction time paradigm: two conditions were defined using tones as S1 (80 or 60 dB) and S2 (70 dB). The following results were obtained. Hypotensive patients performed significantly more poorly on one subtest of the ACE, which indicates a reduced speed for switching from a routine to a controlled response (quantifying attentional flexibility). They also had longer reaction times and revealed a significantly smaller amplitude of the early CNV component. In addition, a significant correlation was observed between systolic blood pressure and the amplitude of the early CNV component. The data support previous findings that hypotension can be related to lowered cortical activation and indicate that specific aspects of attentional performance might be negatively affected by hypotension. ᮊ 2002 Elsevier Science B.V. All rights reserved.Keywords: Hypotension; Systolic blood pressure; Contingent negative variation; Reaction time; Attentional flexibility; ACE battery Essential hypotension can be described as the chronic condition of low blood pressure that is independent from another illness or pathology. There is no general agreement as to when exactly the diagnosis 'hypotension' applies. Most authors *Corresponding author. Tel.: q49-7531-88-4606; fax: q49-7531-88-2891. E-mail address: nathan.weisz@uni-konstanz.de (N. Weisz).suggest a systolic blood pressure (SBP) below 100-110 mmHg as a cut-off value. (Weiss and Donat, 1982;Pschyrembel, 1993). We refer to the 'essential' form when speaking of hypotension in this work, which should not be confused with secondary (i.e. symptomatic) or orthostatic forms. Even though essential hypotension is by far the most common type of hypotension (90%; Phillipp, 1993), its aetiology is still unknown.

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Heartbeat evoked potentials (HEP): topography and influence of cardiac awareness and focus of attention

Cited by 197 publications

References 18 publications

A cortical potential reflecting cardiac function

A cortical potential reflecting cardiac function

The neural subjective frame: from bodily signals to perceptual consciousness

Early contingent negative variation of the EEG and attentional flexibility are reduced in hypotension

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