Heartbeat-enhanced immersive virtual reality to treat complex regional pain syndrome

Solcà, Marco; Ronchi, Roberta; Bello-Ruiz, Javier; Schmidlin, Thomas W.; Herbelin, Bruno; Lüthi, François; Konzelmann, M.; Beaulieu, Jean-Yves; Delaquaize, F; Schnider, Armin; Guggisberg, Adrian G.; Serino, Andrea; Blanke, Olaf

doi:10.1212/wnl.0000000000005905

Cited by 72 publications

(52 citation statements)

References 67 publications

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“…neurosurgery, firemen, pilots), cognitive behavioral therapy (e.g. treating phobias or post-traumatic stress disorder), and as pain treatments [139,140]. Future work is needed in order to explore the differences between VR and traditional studies in terms of learning and performance.…”

Section: Discussionmentioning

confidence: 99%

First-person view of one’s body in immersive virtual reality: Influence on episodic memory

et al. 2019

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Episodic memories (EMs) are recollections of contextually rich and personally relevant past events. EM has been linked to the sense of self, allowing one to mentally travel back in subjective time and re-experience past events. However, the sense of self has recently been linked to online multisensory processing and bodily self-consciousness (BSC). It is currently unknown whether EM depends on BSC mechanisms. Here, we used a new immersive virtual reality (VR) system that maintained the perceptual richness of life episodes and fully controlled the experimental stimuli during encoding and retrieval, including the participant’s body. Our data reveal a classical EM finding, which shows that memory for complex real-life like scenes decays over time. However, here we also report a novel finding that delayed retrieval performance can be enhanced when participants view their body as part of the virtual scene during encoding. This body effect was not observed when no virtual body or a moving control object was shown, thereby linking the sense of self, and BSC in particular, to EMs. The present VR methodology and the present behavioral findings will enable to study key aspects of EM in healthy participants and may be especially beneficial for the restoration of self-relevant memories in future experiments.

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Section: Discussionmentioning

confidence: 99%

First-person view of one’s body in immersive virtual reality: Influence on episodic memory

et al. 2019

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“…The available studies on assessment and treatment described here need to be replicated in larger and higher-methodological quality studies with appropriate control groups, in order to confirm preliminary results emerged, and to determine whether perceptual disorders represent clinical consistent findings. At the same time, we encourage the production of diagnostic case studies/case series and the publication of preliminary validation studies aimed to describe new assessment and treatment methodology in MDRDs as already made in CRPS (Sumitani et al, 2007a;Uematsu et al, 2009;Christophe et al, 2016;Solcà et al, 2018). We think that these two preliminary steps may be useful starting points before large scale data collection, as in the case of Adamczyk et al (2018a,b).…”

Section: Recommendation For Future Researchmentioning

confidence: 91%

Explicit and Implicit Own's Body and Space Perception in Painful Musculoskeletal Disorders and Rheumatic Diseases: A Systematic Scoping Review

Viceconti

Camerone

Luzzi

et al. 2020

Front. Hum. Neurosci.

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Background: Pain and body perception are essentially two subjective mutually influencing experiences. However, in the field of musculoskeletal disorders and rheumatic diseases we lack of a comprehensive knowledge about the relationship between body perception dysfunctions and pain or disability. We systematically mapped the literature published about the topics of: (a) somatoperception; (b) body ownership; and (c) perception of space, analysing the relationship with pain and disability. The results were organized around the two main topics of the assessment and treatment of perceptual dysfunctions.Methods: This scoping review followed the six-stage methodology suggested by Arksey and O'Malley. Ten electronic databases and grey literature were systematically searched. The PRISMA Extension for Scoping Reviews was used for reporting results. Two reviewers with different background, independently performed study screening and selection, and one author performed data extraction, that was checked by a second reviewer.Results: Thirty-seven studies fulfilled the eligibility criteria. The majority of studies (68%) concerned the assessment methodology, and the remaining 32% investigated the effects of therapeutic interventions. Research designs, methodologies adopted, and settings varied considerably across studies. Evidence of distorted body experience were found mainly for explicit somatoperception, especially in studies adopting self-administered questionnaire and subjective measures, highlighting in some cases the presence of sub-groups with different perceptual features. Almost half of the intervention studies (42%) provided therapeutic approaches combining more than one perceptual task, or sensory-motor tasks together with perceptual strategies, thus it was difficult to estimate the relative effectiveness of each single therapeutic component.Viceconti et al. Body Perception in Musculoskeletal DisordersConclusions: To our knowledge, this is the first attempt to systematically map and summarize this research area in the field of musculoskeletal disorders and rheumatic diseases. Although methodological limitations limit the validity of the evidence obtained, some strategies of assessment tested and therapeutic strategies proposed represent useful starting points for future research. This review highlights preliminary evidence, strengths, and limitations of the literature published about the research questions, identifying key points that remain opened to be addressed, and make suggestions for future research studies. Body representation, as well as pain perception and treatment, can be better understood if an enlarged perspective including body and space perception is considered.

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“…However, other possibilities could be explored, such as tactile feedback on a non-allodynic area or other congruent sensory modalities. Another potential alternative is to use interoceptive information such as heartbeat, together with vision, to provide this input (Solcà et al, 2018).…”

Section: Patients With Allodyniamentioning

confidence: 99%

Immersive Virtual Reality for Clinical Pain: Considerations for Effective Therapy

Donegan

Ryan

Świdrak

et al. 2020

Front. Virtual Real.

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Immersive virtual reality is transforming medical and psychological research and treatment, including the treatment of clinical pain. In this short perspective paper, we present some of the methodological difficulties that are rarely discussed in the literature of pain research when using virtual reality. These often-unmentioned problems can confound research investigations or interfere with the therapeutic efficacy in clinical trials. We propose practical solutions based on our research experience. We first outline the mechanisms of, and challenges to, the sensations of embodiment and presence, which are critical to creating effective virtual reality illusions, before discussing the particular considerations that need to be contemplated when working with patients with clinical pain. Finally, we discuss some upcoming technological advances that may influence significantly this rapidly expanding field in the near future.

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Heartbeat-enhanced immersive virtual reality to treat complex regional pain syndrome

Abstract: This study provides Class III evidence that HEVR reduces pain and increases force strength in patients with CRPS.

Cited by 72 publications

References 67 publications

First-person view of one’s body in immersive virtual reality: Influence on episodic memory

First-person view of one’s body in immersive virtual reality: Influence on episodic memory

Explicit and Implicit Own's Body and Space Perception in Painful Musculoskeletal Disorders and Rheumatic Diseases: A Systematic Scoping Review

Immersive Virtual Reality for Clinical Pain: Considerations for Effective Therapy

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