Heart valve operation in acromegaly

Mitral Valve Repair in a Patient With Acromegaly. Case Report.

“…12 Only a few patients are reported to have had valvular diseases. [4][5][6][7][8][9][10][11] Lie and Grossman reported aortic and mitral valvular heart disease in 5 (19%) of 27 cases, 4 and the valvular lesions are usually found in the late stage of acromegalic cardiomyopathy. 13 In the present patient, no significant coronary artery diseases were found, but systemic hypertension, arrhythmias, and valvular disease were detected.…”

“…[2][3][4][5][6][7][8][9][10][11] To our knowledge, only a few surgical cases of valvular disease associated with acromegaly have been previously described. [5][6][7][8][9] We present a patient with acromegaly associated with mitral regurgitation (MR), which was successfully managed by valve repair.…”

Mitral Valve Repair in a Patient with Acromegaly

“…6) Surgery was performed under standard cardiopulmonary bypass. P 2 scallop prolapse without torn chordae was identified, and the MV was repaired by quadrant leaflet resection and annuloplasty with a Carpenter-Edwards physioring (Edwards Lifesciences, Irvine, CA, USA).…”

“…However, cardiac operation was conducted before resection of the functional pituitary tumor in the present case because symptomatic, severe mitral regurgitation carries a high risk in patients with acromegaly, and, therefore, early-as-possible cardiac operation is recommended. 6) Resection of the functional pituitary tumor allowed for control of GH levels and IGF-I excess, which is important in achieving long-term durability with MV repair.…”

“…4,5) Ohtsuka and colleagues reported ring fragility and leaflet disarray in MVs, suggesting that valve replacement was more likely to achieve a better outcome than valve repair. 6) In contrast, Cable and colleagues reported success in surgically repairing MVs in patients with acromegaly including active endocrinopathy. 7) Here, we report on a successful MV repair and modified Cox maze procedure in a patient with acromegaly, associated with severe mitral regurgitation and atrial fibrillation.…”