Heart Transplantation for Progressive Cardiomyopathy as a Manifestation of MELAS Syndrome

Bhati, Rajendra; Sheridan, Brett C.; Mill, Michael R.; Selzman, Craig H.

doi:10.1016/j.healun.2005.05.012

Cited by 30 publications

(24 citation statements)

References 18 publications

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“…The median age distribution was similar in the PPCM, Pϩ, and PϪ Groups, and in the men: 31, 32, 30, and 32 years, respectively, shown in Figure 3. The PPCM Group and the Pϩ Group each had a median number of 2 pregnancies each (range, [1][2][3][4][5][6][7][8][9][10][11][12]. Most patients in all 4 groups were non-African American, but the proportion of African American patients was higher in the PPCM Group at 41%, than in the Pϩ, PϪ, and the Male Group at 34%, 17%, and 28%, respectively (chi-square, p ϭ 0.02).…”

Section: Results Demographicsmentioning

confidence: 99%

Long-term Outcomes of Cardiac Transplantation for Peri-partum Cardiomyopathy: A Multiinstitutional Analysis

Rasmusson¹,

Stehlik²,

Brown³

et al. 2007

The Journal of Heart and Lung Transplantation

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Section: Results Demographicsmentioning

confidence: 99%

Long-term Outcomes of Cardiac Transplantation for Peri-partum Cardiomyopathy: A Multiinstitutional Analysis

Rasmusson¹,

Stehlik²,

Brown³

et al. 2007

The Journal of Heart and Lung Transplantation

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“…Heart transplantation has been performed in several cases of mitochondrial cardiomyopathy, e.g. mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) (Bhati et al, 2005). Mitochondrial depletion syndrome due to deoxyguanosine kinase (DGUOK) deficiency often results in isolated liver failure and could therefore be successfully treated by liver transplantation (Dimmock et al, 2008).…”

Section: Transplantationmentioning

confidence: 99%

Keep the fire burning: Current avenues in the quest of treating mitochondrial disorders

Tischner

Wenz

2015

Mitochondrion

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“…For instance, cardiac transplantation with a 50% survival rate has been reported in six patients with mitochondrial cardiomyopathy (Bonnet et al 2001). More recently, a successful recipient outcome for two patients with MELAS was reported (Bhati et al 2005). Liver function is often impaired, especially in mtDNA depletion syndromes.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Mitochondrial medicine: to a new era of gene therapy for mitochondrial DNA mutations

Cwerman-Thibault

Sahel

Corral‐Debrinski

2010

J of Inher Metab Disea

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Mitochondrial disorders can no longer be ignored in most medical disciplines. Such disorders include specific and widespread organ involvement, with tissue degeneration or tumor formation. Primary or secondary actors, mitochondrial dysfunctions also play a role in the aging process. Despite progresses made in identification of their molecular bases, nearly everything remains to be done as regards therapy. Research dealing with mitochondrial physiology and pathology has >20 years of history around the world. We are involved, as are many other laboratories, in the challenge of finding ways to fight these diseases. However, our main limitation is the scarcety of animal models required for both understanding the molecular mechanisms underlying the diseases and evaluating therapeutic strategies. This is especially true for diseases due to mutations in mitochondrial DNA (mtDNA), since an authentic genetic model of mtDNA mutations is technically a very difficult task due to both the inability of manipulating the mitochondrial genome of living mammalian cells and to its multicopy nature. This has led researchers in the field to consider the prospect of gene therapy approaches that can roughly be divided into three groups: (1) import of wild-type copies or relevant sections of DNA or RNA into mitochondria, (2) manipulation of mitochondrial genetic content, and (3) rescue of a defect by expression of an engineered gene product from the nucleus (allotopic or xenotropic expression). We briefly introduce these concepts and indicate where promising progress has been made in the last decade.

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Heart Transplantation for Progressive Cardiomyopathy as a Manifestation of MELAS Syndrome

Cited by 30 publications

References 18 publications

Long-term Outcomes of Cardiac Transplantation for Peri-partum Cardiomyopathy: A Multiinstitutional Analysis

Long-term Outcomes of Cardiac Transplantation for Peri-partum Cardiomyopathy: A Multiinstitutional Analysis

Keep the fire burning: Current avenues in the quest of treating mitochondrial disorders

Mitochondrial medicine: to a new era of gene therapy for mitochondrial DNA mutations

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