Heart Rate Variability Today

Xhyheri, Borejda; Manfrini, Olivia; Mazzolini, Massimiliano; Pizzi, Carmine; Bugiardini, Raffaele

doi:10.1016/j.pcad.2012.09.001

Cited by 363 publications

(315 citation statements)

References 126 publications

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“…It is well known that decreased HRV is associated with numerous health problems including increased allcause mortality, ventricular arrhythmia mortality, heart failure, diabetes mellitus type 2 risks even without evidence of autonomic neuropathy, liver damage, hypertension and many other problems [8]. There is growing evidence that a decrease in HRV eventually may appear not only as a conse- quence of decreased activities of sympathetic and parasympathetic branches of autonomic nervous system, but also as an independent metabolic phenomenon, related to possible impairment of cardiomyocytes, especially cells of sinoatrial node (SAN) that may be less responsive to the neural and humoral impacts [18].…”

Section: Discussionmentioning

confidence: 99%

“…The consensus exists that the parameters of HRV reflect the activities of sympathetic and parasympathetic branches of the autonomic nervous system. Among the most important associations of reduced HRV reported to the date are all cause mortality, risk of fatal arrhythmias, and many others [8]. In addition, the relationships of HRV to important inflammatory parameters as well as insulin resistance, oxidative stress and dyslipidemia have been established [9,10].…”

Section: Introductionmentioning

confidence: 99%

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A marked decrease in heart rate variability in Marfan syndrome patients with confirmed FBN1 mutations

Cherkas

Zhuraev

2016

Cardiol J.

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Results: Heart rates in MS patients with the FBN1 mutation were increased in both the supine position and orthostatic test (p < 0.001). Most of the time-domain (standard deviation, pNN50) and frequency-domain (total power, very low, low, and high frequency) parameters of HRV were significantly reduced in the MS patients (p < 0.001).Conclusions: A marked decrease in HRV, documented in the study, may be an important clinical feature in MS patients with confirmed FBN1 gene mutations. (Cardiol J 2016; 23, 1: 23-33)

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A marked decrease in heart rate variability in Marfan syndrome patients with confirmed FBN1 mutations

Cherkas

Zhuraev

2016

Cardiol J.

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“…Also, HRV is also a relatively independent and correlated indicator to judge the prognosis of cardiovascular disease. [22][23][24] HRV markers include SDANN reflecting the sympathetic nerve activity, rMSSD, and PNN50 reflecting the parasympathetic activity as well as SDNN reflecting a whole autonomic nervous function. In this study, we used ambulatory electrocardiography to examine the autonomic nervous function.…”

Section: Discussionmentioning

confidence: 99%

The relationship between left ventricular diastolic function and the autonomic nervous function in elderly patients with mild-to-moderate essential hypertension

Liu

Lin

Dong

et al. 2018

CRIM

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Objective: To investigate the relationship between left ventricular diastolic function (LVDF) and autonomic nervous function in elderly patients with mild-to-moderate essential hypertension. Design: A total of 146 elderly patients with mild-to-moderate essential hypertension were enrolled in our hospital from January, 2015 to October, 2017. Blood pressure was recorded, and biochemical indexes and the N-terminal pro-brain natriuretic preptide (NT-proBNP) were investigated. 2-dimensional echocadiolography was used to measure the parameters of LVDF. Based on the classification standard of LVDF, all subjects were divided into two groups: normal LVDF group (n = 72), left ventricular diastolic dysfunction group (n = 74). At the same time, the dynamic electrocardiogram were investigated for all subjects to monitor the indexes of time on heart rate variability (HRV). Results: (1) The level of NT-proBNP, left ventricular mass index (LVMI), interventricular septal thickness (IVST) and LVPWT increased significantly (p < .05 for all), while the level of PNN50, rMSSD, SDANN and SDNN decreased significantly (p < .05 for all) in left ventricular diastolic dysfunction group (abnormal LVDF group) compared with that in normal LVDF group (normal LVDF group); (2) The partial correlation analysis showed that rMSSD, PNN50 and triangle index were negatively correlated with peak A (r = -0.208, -0.219, -0.211, p < .05 for all), and positive correlated with the ratio of peak E to peak A (E/A) (r = 0.179, 0.184, 0.181, p < .05); SDNN were negatively correlated with NT-proBNP and E/E' (r = -0.183, -0.181, p < .05 for all), positive correlated with E' (r = 0.178, p < .05); (3) Multiple stepwise regression analysis showed that peak A and E/A were independent influencing factors for PNN50 (β = -0.261, p = .004; β = 0.179, p = .016); E/E' and NT-proBNP were independent influencing factor for SDNN (β = -0.163, p = .018; β = -0.172, p = .022). Conclusions: Left ventricular diastolic dysfunction is closely related to impaired autonomic nervous function in elderly patients with mild-to-moderate essential hypertension.

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“…Frequency domain methods of HRV can be used with even shorter intervals (2-5 minutes) without missing relevant information on HRV (Task Force of the European Society of Cardiology the North American Society of Pacing Electrophysiology 1996; Xhyheri et al 2012). Spectral analysis was conducted offline by continuous wavelet transformation by using Fluclet™ (DaiNippon Sumitomo Pharmaceutical Co., Ltd., Osaka, Japan).…”

Section: Power Spectral Analysismentioning

confidence: 99%

“…A high glycemic status induces the presence of heightened sympathetic and reduced parasympathetic activity, which is supported by previous studies in patients with diabetes mellitus compared to non-diabetes or healthy adults at rest (Liao et al 1995;Santini et al 2007). Generally, HRV parameters decrease in patients with diabetes mellitus (Task Force of the European Society of Cardiology the North American Society of Pacing Electrophysiology 1996; Xhyheri et al 2012), although it is considered that these observations occur with the progression of diabetes mellitus and are probably due to the complication of autonomic neuropathy (Schroeder et al 2005). Since our study was performed on participants who did not meet the diagnostic criteria for r, Partial correlation between the level of HbA1c and HRV by using partial correlation analysis.…”

Section: The Effect Of a High Glycemic Status On The Autonomic Responmentioning

confidence: 99%

Elevated HbA1c Levels Are Associated with the Blunted Autonomic Response Assessed by Heart Rate Variability during Blood Volume Reduction

Kamakura

Maruyama

2016

Tohoku J. Exp. Med.

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A high glycemic status increases the risk for autonomic dysfunction and cardiovascular failure. The aim of this study was to investigate time-dependent changes in the autonomic response and cardiovascular dynamics and the association between the level of hemoglobin A1c (HbA1c) and autonomic response during blood volume reduction. The study population consisted of 26 preoperative participants who were scheduled for autologous blood donation (200-400 mL of whole blood) for intraoperative or postoperative use. These participants without circulatory, respiratory, or brain disease and diabetes mellitus were grouped according to their HbA1c levels: < 6.5% (n = 18) and ≥ 6.5% (n = 8). We measured blood pressure (BP) and analyzed heart rate variability (HRV) to quantify cardiac autonomic regulation throughout blood donation. During blood volume reduction, which was about 10% of the circulating blood volume, the BP and heart rate varied within normal ranges in both groups. The high-frequency (HF) component, an index of parasympathetic nerve activity, and the ratio of low-frequency (LF) to HF components (LF/HF), an index of sympathetic nerve activity, significantly decreased and increased with the progression of blood volume reduction, respectively, in the HbA1c < 6.5% group. In contrast, in the HbA1c ≥ 6.5% group, the HF component did not significantly change, and the increase in the LF/HF ratio was delayed. Time-dependent changes in HRV were related to blood volume reduction only in the HbA1c < 6.5% group. Thus, elevated HbA1c levels are associated with the decrease in the autonomic response induced by blood volume reduction.

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Heart Rate Variability Today

Cited by 363 publications

References 126 publications

A marked decrease in heart rate variability in Marfan syndrome patients with confirmed FBN1 mutations

A marked decrease in heart rate variability in Marfan syndrome patients with confirmed FBN1 mutations

The relationship between left ventricular diastolic function and the autonomic nervous function in elderly patients with mild-to-moderate essential hypertension

Elevated HbA1c Levels Are Associated with the Blunted Autonomic Response Assessed by Heart Rate Variability during Blood Volume Reduction

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