Heart rate variability of typically developing and autistic children and adults before, during and after sleep

Tessier, Michelle; Pennestri, Marie‐Hélène

doi:10.1016/j.ijpsycho.2018.10.004

Cited by 20 publications

(18 citation statements)

References 53 publications

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“…The STV and HF (ln) of male Sal, male VPA, and female Sal mice were significantly increased from 4 to 8 weeks of age, whereas these of female VPA mice remained unchanged, suggesting the strong suppression of parasympathetic nervous development in female VPA mice. Several reports revealed that the assessment of the sympathetic and parasympathetic activity using HRV in children with ASD yielded inconsistent results [25][26][27]48 . As ASD is a heterogeneous disease 1 , it can be inferred that such diversity occurred because of the characteristics of the population and the environmental factors that were involved in the studies.…”

Section: Discussionmentioning

confidence: 99%

“…ECG analysis of children and adults diagnosed with ASD has revealed lower autonomic nervous activity compared with healthy individuals. This lower activity has been hinted to be associated with the pathology of ASD [25][26][27] . In addition, the sympathetic and parasympathetic interaction is associated with externalizing behavior problems in children with ASD 28 .…”

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confidence: 95%

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Alterations in the autonomic nerve activities of prenatal autism model mice treated with valproic acid at different developmental stages

Kasahara

Yoshida

Nakanishi

et al. 2020

Sci Rep

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Autism spectrum disorder (ASD) is characterized by impairment of social communication, repetitive behavior and restrictive interest. The risk of ASD is strongly associated with the prenatal period; for instance, the administration of valproic acid (VPA) to pregnant mothers increases risk of ASD in the child. Patients with ASD often exhibit an alteration in the autonomic nervous system. In this study, we assessed the autonomic nervous activity at each prenatal developmental stage of model mice of ASD treated with VPA, to clarify the relationship between timing of exposure and ASD symptoms. The assessment of the autonomic nervous activity was performed based on the analysis of electrocardiography data collected from fetal and adult mice. Interestingly, VPA model mouse fetuses exhibited a significantly lower activity of the sympathetic nervous system. In contrast, sympathetic nervous activity at P0 was significantly higher. In adult VPA model mice, the parasympathetic activity of female VPA mice was suppressed. Moreover, female VPA mice showed reduced the parasympathetic activity after exposure to restraint stress. These results suggest that the autonomic nervous activity of VPA model mice was altered from the fetal stage, and that the assessment of autonomic nervous activities at an early developmental stage could be useful for the understanding of ASD.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 95%

Alterations in the autonomic nerve activities of prenatal autism model mice treated with valproic acid at different developmental stages

Kasahara

Yoshida

Nakanishi

et al. 2020

Sci Rep

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“…Across different age groups, there were no such patterns. At all age groups, some studies showed group differences with pre-school children (Anderson et al, 2013;Billeci et al, 2018), children and adolescents (Bal et al, 2010;Bricout et al, 2018) and adults (Eilam-Stock et al, 2014;Kuiper et al, 2019) while other studies did not find group differences with pre-school children (McCormick et al, 2014;Nuske et al, 2014), children and adolescents (Schaaf et al, 2015;Tessier et al, 2018), and adults (Bolte et al, 2008;Dijkhuis et al, 2019). Similarly, the findings of hyperarousal came equally from studies of children and adolescents (Bal et al, 2010;Matsushima et al, 2016) and adults (Mathewson et al, 2011;Top et al, 2018) and findings of hypoarousal were also equally likely from studies of children and adolescents (Bujnakova et al, 2017;Pace and Bricout, 2015) and adults (Eilam-Stock et al, 2014;Mathersul et al, 2013a).…”

Section: Agementioning

confidence: 95%

“…One study that aimed to test age effects specifically (Tessier et al, 2018) examined spectral HRV in children (6-13 years) and adults (16-27 years) before and after sleep at rest. Interestingly, they reported a group effect in adults but not in children such that only autistic adults presented with reduced HF-HRV (and hence reduced parasympathetic activation) as compared to neurotypical adults.…”

Section: Agementioning

confidence: 99%

Is autonomic function during resting-state atypical in Autism: A systematic review of evidence

Arora¹,

Bellato²,

Ropar³

et al. 2020

Preprint

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Theories of differences in resting-state arousal in autistic individuals are influential. Differences in arousal during resting-state would impact engagement and adaptation to the environment, having a cascading effect on development of attentional and social skills. In this review, we evaluate the evidence for differences in autonomic arousal during resting-state in autistic individuals, and importantly, whether there are contextual or methodological factors that impact reports of such differences. We carried out a systematic review of the literature on 60 studies, which measured autonomic function (using indices of heart rate, pupillometry or electrodermal activity) during rest or a pre-task baseline. Of the 51 studies that investigated group differences between neurotypical and autistic participants, 60.8% of the studies found evidence of group differences. While findings of hyperarousal were more common, particularly using indices of parasympathetic function, findings of hypoarousal and autonomic dysregulation were also consistently present. Importantly, experimental context played a role in revealing such differences. The evidence is discussed with regard to important methodological factors and implications for future research are described.

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“…The results show that the myocardium of these patients with pneumonia is seriously damaged and the prognosis is not better. It is worthwhile to strengthen the dynamic ECG monitoring, adjust the dosage and type of drugs in time, treat symptoms and prevent accidents [21]. As many as 4 million patients worldwide die of pneumonia every year, the main reason is that pneumonia tends to cause hypoxia and heart failure in patients, especially in many developing countries [22].…”

Section: Discussionmentioning

confidence: 99%

Signal Analysis of Electrocardiogram and Statistical Evaluation of Myocardial Enzyme in the Diagnosis and Treatment of Patients With Pneumonia

Zhou

Zeng

et al. 2019

IEEE Access

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Pneumonia is a common disease in patients. This paper discusses the signal processing techniques of electrocardiogram (ECG) and the statistical analysis of myocardial enzymes in the diagnosis and treatment of patients with pneumonia and analyzes its significance. Detecting the activity of creatine kinase (CK), isoenzyme (CK-MB), and cardiac troponin T (CTnT) before and after treatment in patients with pneumonia and recording the changes of the electrocardiogram with non-invasive bedside conventional electrocardiogram can be useful for medical diagnosis. In addition, in order to eliminate the ECG signal noise to improve the accuracy of analysis and diagnosis, we have introduced a Butterworth filter to achieve the suppression of interference signals. Moreover, the Butterworth filter method is used to denoise the ECG signal, and the selection of wavelet function, the analysis of noise frequency band, and the threshold processing are solved accordingly. This method has the characteristics of simple calculation and fast processing speed. It can effectively suppress baseline drift noise and improve the overall operation speed. The experimental results show that the proposed method can well filter baseline drift, power frequency interference, EMG interference, and other high-frequency interference in ECG signals, and the real-time performance of the Butterworth filter method in the sampling process has good performance, which provides help for diagnosis. Via comparing and analyzing different ECG signal parameters between the groups, the serum levels of CK, CK-MB, and troponin are demonstrated to be significantly increased with the severity of the disease in patients with pneumonia. Abnormal changes in the ECG indicate that the myocardium may be affected after pneumonia in patients. The detection of CK-MB and troponin levels in the serum of patients with pneumonia has very high sensitivity and specificity. Recording electrocardiogram has good intuitive utility. ECG and myocardial enzyme monitoring are of great significance in the diagnosis and treatment of the development of the disease in patients with pneumonia. INDEX TERMS Electrocardiogram signal, Butterworth filter, interference signal, pneumonia, myocardial enzyme.

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Heart rate variability of typically developing and autistic children and adults before, during and after sleep

Cited by 20 publications

References 53 publications

Alterations in the autonomic nerve activities of prenatal autism model mice treated with valproic acid at different developmental stages

Alterations in the autonomic nerve activities of prenatal autism model mice treated with valproic acid at different developmental stages

Is autonomic function during resting-state atypical in Autism: A systematic review of evidence

Signal Analysis of Electrocardiogram and Statistical Evaluation of Myocardial Enzyme in the Diagnosis and Treatment of Patients With Pneumonia

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