Heart rate variability measure in breast cancer patients and survivors: A systematic review

Arab, Claudia; Dias, Daniel Penteado Martins; Barbosa, Renata Thaís de Almeida; Carvalho, Tatiana Dias de; Valenti, Vítor Engrácia; Crocetta, Tânia Brusque; Ferreira, Marcelo; Abreu, Luíz Carlos de; Ferreira, Celso

doi:10.1016/j.psyneuen.2016.02.018

Cited by 80 publications

(71 citation statements)

References 76 publications

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“…The results of the study of Lončar-Turukalo et al [31] confirmed HRV alteration as an early marker of cardiotoxicity in DOX-induced cardiomyopathy in healthy rats. Since it is known that illness itself can provoke autonomic modulation [32], a rat model of colorectal cancer was applied in our study to reveal whether HRV changes can be used as a marker of DOX-induced cardiotoxicity in cancer.…”

Section: Introductionmentioning

confidence: 99%

Cardiac autonomic modulation induced by doxorubicin in a rodent model of colorectal cancer and the influence of fullerenol pretreatment

et al. 2017

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The very effective anticancer drug doxorubicin (DOX) is known to have cardiotoxic side effects, which could be accompanied by autonomic modulation. Autonomic disbalance might even be an initiating mechanism underlying DOX-induced cardiotoxicity and can be studied noninvasively by the analysis of heart rate variability (HRV). A number of strategies have been assessed to predict chemotherapy-induced cardiac dysfunction while HRV, a potential detecting tool, has not yet been tested. Thus, we aimed to determine the effect of DOX treatment on HRV in a rat model of colorectal cancer. While pretreatment with fullerenol (Frl) acts protectively on DOX-induced cardiotoxicity, we aimed to test the effect of Frl pretreatment on DOX-induced HRV alterations. After the induction of colorectal cancer, adult male Wistar rats were treated with saline (n = 7), DOX (1.5 mg/kg per week, n = 7) or DOX after pretreatment with Frl (25 mg/kg per week, n = 7) for three weeks (cumulative DOX dose 4.5 mg/kg). One week after treatment rats were anaesthetized, standard ECG was measured and HRV was analyzed in time and frequency domain. During autopsy the intestines and hearts were gathered for biochemical analysis and histopathological examination. DOX treatment significantly decreased parasympathetically mediated high-frequency component (p<0.05) and increased the low-frequency component of HRV (p<0.05), resulting in an increased LF/HF ratio (p<0.05) in cancerous rats. When pretreated with Frl, DOX-induced HRV alterations were prevented: the high-frequency component of HRV increased (p<0.01), the low-frequency decreased (p<0.01), LF/HF ratio decreased consequently (p<0.01) compared to DOX only treatment. In all DOX-treated animals, disbalance of oxidative status in heart tissue and early myocardial lesions were found and were significantly reduced in rats receiving Frl pretreatment. Autonomic modulation accompanied the development of DOX-induced cardiotoxicity in rat model of colorectal cancer and was prevented by Frl pretreatment. Our results demonstrated the positive prognostic power of HRV for the early detection of DOX-induced cardiotoxicity.

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Section: Introductionmentioning

confidence: 99%

Cardiac autonomic modulation induced by doxorubicin in a rodent model of colorectal cancer and the influence of fullerenol pretreatment

et al. 2017

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“…Considering the opinion of authors that the analysis of heart rate variability can be used as an important additional highly sensitive noninvasive tool in early diagnostics of cardiovascular diseases, improvement of autonomic dysfunction prognosis, survivability of patients, and other clinical applications, the discovered dependencies and the availability of standardized methods of registration and computation of the chosen heart rate variability indices allow to confirm the possibility of using the chosen heart rate variability indices as predictors of aging.…”

Section: Discussionmentioning

confidence: 99%

Predictors of aging based on the analysis of heart rate variability

Botsva

Naishtetik

Khimion

et al. 2017

Pacing Clinical Electrophis

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The use of neural network computations and the modification of the algorithm through the construction of individual training samples for different age intervals, and the creation of individual ensembles of classification neural networks, therefore achieved a prediction of the age of examined persons based on the values of their time and frequency domain heart rate variability indices, with 87% accuracy for women and 85% accuracy for men in the 66-85 years age interval and at least 85% for age groups across the entire sample.

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“…Treatment with anthracyclines like doxorubicin, a class of chemotherapeutics commonly used in the treatment of breast cancer, are thought to lower HRV [82•]. Several studies reported an association between lower HRV and fatigue in breast cancer survivors [92]. Fagundes et al showed a lower resting-state HRV and higher norepinephrine levels in association with higher fatigue in breast cancer survivors.…”

Section: Neuroendocrine Function and Symptom Experiencementioning

confidence: 99%

Mechanisms of Neurotoxic Symptoms as a Result of Breast Cancer and Its Treatment: Considerations on the Contribution of Stress, Inflammation, and Cellular Bioenergetics

Lacourt

Heijnen²

2017

Curr Breast Cancer Rep

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Purpose of ReviewBreast cancer and its treatment are associated with a range of neurotoxic symptoms, such as fatigue, cognitive impairment, and pain. Although these symptoms generally subside after treatment completion, they become chronic in a significant subset of patients. We here summarize recent findings on neuroinflammation, stress, and mitochondrial dysfunction as mechanistic pathways leading to neurotoxic symptom experience in breast cancer patients and survivors.Recent FindingsNeuroinflammation related to stress or cancer treatment and stress resulting from diagnosis, treatment, or (cancer-related) worrying are important predictors of a neurotoxic symptom experience, both during and after treatment for breast cancer. Both inflammation and stress hormones, as well as cancer treatment, can induce mitochondrial dysfunction resulting in reduced cellular energy.SummaryWe propose reduced cellular energy (mitochondrial dysfunction) induced by inflammation, oxygen radical production, and stress as a result of cancer and/or cancer treatment as a final mechanism underlying neurotoxic symptoms.

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Heart rate variability measure in breast cancer patients and survivors: A systematic review

Cited by 80 publications

References 76 publications

Cardiac autonomic modulation induced by doxorubicin in a rodent model of colorectal cancer and the influence of fullerenol pretreatment

Cardiac autonomic modulation induced by doxorubicin in a rodent model of colorectal cancer and the influence of fullerenol pretreatment

Predictors of aging based on the analysis of heart rate variability

Mechanisms of Neurotoxic Symptoms as a Result of Breast Cancer and Its Treatment: Considerations on the Contribution of Stress, Inflammation, and Cellular Bioenergetics

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