Heart rate variability in the irritable bowel syndrome: a review of the literature

Mazurak, Nazar; Seredyuk, N. M.; Sauer, Heinrich; Teufel, Martin; Enck, Paul

doi:10.1111/j.1365-2982.2011.01866.x

Cited by 89 publications

(91 citation statements)

References 88 publications

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“…24 IBS-C patients was focused on due to a unique pattern of HRV and GI symptoms. 5 IBS-C patients are known experience more severe upper GI symptoms and lower GI bloating than those with other subtypes of IBS, suggesting greater vagal mediation of afferent signals.…”

Section: Introductionmentioning

confidence: 99%

“…Among the subtypes, IBS-C is the most prevalent, accounting for at least one-third to 58% of all IBS, particularly in females and younger individuals. [5][6][7][8][9] IBS interferes with social function, decreases quality of life, and increases health care costs. 10 A systematic review on IBS indicated that the direct annual cost of managing IBS ranges from approximately $1600 to $7500 per person.…”

Section: Introductionmentioning

confidence: 99%

“…18,20,21 In a previous study, IBS-C patients had lower HF power and a higher LF/HF ratio than healthy controls, which suggests parasympathetic dysfunction and sympathetic overactivity. 3,5 Non-pharmacologic treatments, such as cognitive behavior therapy (CBT), have been effective in improving somatic symptoms of IBS. 15,22,23 The mechanism by which CBT improves somatic symptoms is related to the regulation of brain-gut axis function.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Cognitive Behavior Therapy on Heart Rate Variability in Young Females with Constipation-predominant Irritable Bowel Syndrome: A Parallel-group Trial

Jang

Hwang

Padhye

et al. 2017

J Neurogastroenterol Motil

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Background/AimsThe relation between heart rate variability (HRV) as non-invasive biomarkers of autonomic function and cognitive behavior therapy (CBT) as non-pharmacological treatments has rarely been examined in patients with constipation-predominant irritable bowel syndrome (IBS-C). The purpose of this study is to evaluate the efficacy of an 8-week CBT intervention on HRV and IBS symptoms, and the correlation of changes in HRV with changes in IBS symptoms among young female nursing students with IBS-C. MethodsThis study consisted of an exploratory subgroup analysis of 43 participants with IBS-C who had been randomly assigned to receive either 8 weeks of CBT (n = 23) or general medical information (control, n = 20). At baseline and 8, 16, and 24 weeks, participants completed a questionnaire assessing their gastrointestinal (GI) symptoms, anxiety, depression, and stress, and their HRV was measured via electrocardiography. ResultsAt the 8-week follow-up, the high-frequency (HF) power was significantly higher, and the low-frequency (LF)/HF ratio was lower in the CBT group than in the control group (P < 0.001 for both), and the severity of GI symptoms (P = 0.003), anxiety (P < 0.001), depression (P < 0.001), and stress (P < 0.001) was significantly lower in the CBT group than in the control group. Changes in the HF power were significantly and inversely associated with changes in GI symptoms, anxiety, depression, and stress at 16 and 24 weeks (P < 0.05 for all; range of r from -0.37 to -0.68). Changes in the LF/HF ratio were also significantly and positively associated with changes in GI symptoms, anxiety, depression, and stress at 16 and 24 weeks (P < 0.05 for all; range of r from 0.38 to 0.60). ConclusionsCBT was effective in managing symptoms in young IBS-C patients and the improvement of symptoms was sustained at 24 weeks following the completion of CBT. Furthermore, indirect measurement of autonomic function using HRV may be a useful objective parameter for assessing response to CBT in young IBS-C patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Cognitive Behavior Therapy on Heart Rate Variability in Young Females with Constipation-predominant Irritable Bowel Syndrome: A Parallel-group Trial

Jang

Hwang

Padhye

et al. 2017

J Neurogastroenterol Motil

View full text Add to dashboard Cite

show abstract

“…Indeed, stress is able to modify visceral sensitivity as well as GI motility, permeability, intestinal microbiota, and immunity of the GI tract, all mechanisms that are involved in the pathophysiology of IBS. In addition, stress is able to modulate the hypothalamic pituitary adrenal (HPA) axis and the autonomic nervous system (ANS) which is the link between the gut and the CNS and an imbalance of the ANS is observed in IBS patients (Pellissier, et al 2010a;Mazurak, et al 2012). The main brain areas involved in stress are the prefrontal cortex, the limbic system (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the amygdala projects to the intermediolateral column cells of the spinal cord, at the origin of the sympathetic nerves, and locus coeruleus (LC) in the pons. It makes the amygdala able to modulate the sympathetic nervous system, the other branch of the ANS, and thus to modulate the sympatho-vagal balance, a marker of brain-gut interactions (Mazurak, et al 2012). iii) The amygdala controls the HPA axis activation either directly or indirectly via the hippocampus (i.e.…”

Section: Introductionmentioning

confidence: 99%