Heart Rate Variability in Rats with Experimental Chronic Heart Failure and Long-Term Exposure to β-Adrenoblockers

Сальников, Е. В.

doi:10.1007/s10517-009-0466-6

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…The decrease in HF values and a concomitant change in LF/HF ratio corresponded to a decrease of parasympathetic tone. Both the results of experimental studies in rats and clinical observations in humans and dogs imply that HRV parameters may change during pharmacotherapy of heart failure, irrespective of its etiology (Tacoy et al 2007, Nolan et al 2008, Sal'nikov 2009, Henze et al 2013, Chom-poosan et al 2014, Dias da Silva et al 2015. Consequently, ST-HRV parameters may soon be applied as prognostic and predictive markers in dogs treated due to CMVD.…”

Section: Discussionmentioning

confidence: 99%

Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls

Bogucki¹,

Noszczyk-Nowak²

2017

Polish Journal of Veterinary Sciences

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Heart rate variability is an established risk factor for mortality in both healthy dogs and animals with heart failure. The aim of this study was to compare short-term heart rate variability (ST-HRV) parameters from 60-min electrocardiograms in dogs with sick sinus syndrome (SSS, n=20) or chronic mitral valve disease (CMVD, n=20) and healthy controls (n=50), and to verify the clinical application of ST-HRV analysis. The study groups differed significantly in terms of both time -and frequency-domain ST-HRV parameters. In the case of dogs with SSS and healthy controls, particularly evident differences pertained to HRV parameters linked directly to the variability of R-R intervals. Lower values of standard deviation of all R-R intervals (SDNN), standard deviation of the averaged R-R intervals for all 5-min segments (SDANN), mean of the standard deviations of all R-R intervals for all 5-min segments (SDNNI) and percentage of successive R-R intervals >50 ms (pNN50) corresponded to a decrease in parasympathetic regulation of heart rate in dogs with CMVD. These findings imply that ST-HRV may be useful for the identification of dogs with SSS and for detection of dysautonomia in animals with CMVD.

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Section: Discussionmentioning

confidence: 99%

Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls

Bogucki¹,

Noszczyk-Nowak²

2017

Polish Journal of Veterinary Sciences

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“…In subjects with decompensated heart failure, beta-blockers were associated with better frequency-domain HRV parameters (total power and ULF) [ 65 , 94 ]. An experimental study with a rat model of chronic heart failure also reported similar findings, with atenolol and pindolol increasing both LF and HF power [ 95 ]. This study revealed augmentation of HRV with the use of beta-blockers supporting their use in patients with heart failure [ 95 , 96 ].…”

Section: Resultsmentioning

confidence: 62%

“…An experimental study with a rat model of chronic heart failure also reported similar findings, with atenolol and pindolol increasing both LF and HF power [ 95 ]. This study revealed augmentation of HRV with the use of beta-blockers supporting their use in patients with heart failure [ 95 , 96 ]. Another element of perioperative medical management is amiodarone, which also reduces the risk of post-operative AF.…”

Section: Resultsmentioning

confidence: 62%

Heart Rate Variability and Coronary Artery Bypass Grafting: A Systematic Review

Matusik,

Alomar,

Hussain

et al. 2024

Rev. Cardiovasc. Med.

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Background: Coronary artery bypass grafting (CABG) is a well-established surgical procedure used to treat significant coronary artery disease. Nevertheless, unfavorable cardiovascular events and complications, including cardiac arrhythmias may be observed in patients after CABG. Previous studies have revealed a relationship between risk of cardiac arrhythmias and abnormal heart rate variability (HRV), which reflects adverse alterations in cardiac autonomic functioning, that may occur in patients after a CABG procedure. The aim of this article was to provide a systematic review of the major research findings in this area. Methods: A literature search was carried out using PubMed, Cochrane, and Embase databases and relevant articles, published in English, were analyzed in detail. Results: Studies performed so far have shown time depending changes in HRV after CABG. Time and frequency domain HRV decrease acutely after CABG but recover almost completely to pre-operative values by 6 months after surgery. Some preoperative clinical states such as: heart failure, type 2 diabetes mellitus and depression adversely affect post-CABG HRV. Finally, post-CABG cardiac rehabilitation appears to improve exercise capacity and speed up recovery of HRV. Conclusions: Generally, traditional time and frequency domain HRV parameters fail to predict complications post-CABG. Altered non-linear measures of HRV may identify subgroups of subjects at increased risk of potential complications, including atrial fibrillation post-CABG. However, data available currently does not appear to unequivocally support the hypothesis that early HRV assessment in post-CABG patients predicts long-term mortality.

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Effect of Adrenoblockers on Slow (LF) Waves in Rabbit Heart Rate

et al. 2014

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Propranolol and atenolol were used to examine the role of the adrenergic system in the genesis of slow HR variations (waves) in rabbits, the animals characterized by pronounced sympathetic influences. The control experiments were performed with physiological solution and long-term records in intact rabbits. The harmonic (spectrum) analysis was performed with fast Fourier transform. The adrenoblockers produced no decrease in the power of slow waves. The study did not found the sympathetic genesis of slow variations in rabbit HR.

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Heart Rate Variability in Rats with Experimental Chronic Heart Failure and Long-Term Exposure to β-Adrenoblockers

Cited by 7 publications

References 8 publications

Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls

Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls

Heart Rate Variability and Coronary Artery Bypass Grafting: A Systematic Review

Effect of Adrenoblockers on Slow (LF) Waves in Rabbit Heart Rate

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