Heart rate variability in premenstrual dysphoric disorder

Landén, Mikael; Wennerblom, Bertil; Tygesen, Hans; Modigh, Kjell; Sörvik, Karin; Ysander, Christina; Ekman, Agneta; Nissbrandt, Hans; Olsson, Marie; Eriksson, Elias

doi:10.1016/s0306-4530(03)00117-3

Cited by 45 publications

(51 citation statements)

References 62 publications

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“…Differences in methodology may explain the different results between Landen et al (12) and our study. First, in our study, four women did not qualify for a diagnosis of PMDD, based on prospective ratings, whereas all the women included in the study by Landen et al (12) met DSM-IV criteria for a PMDD diagnosis.…”

Section: Discussioncontrasting

confidence: 75%

“…Time-domain HRV components were assessed from 24-h electrocardiograph (ECG) recordings and spectral HRV components were determined from 10-min recordings in the supine position when breathing was controlled, followed by 10-min in a standing position. RMSSD, SDNN, and supine HF power were significantly lower in 28 women with PMDD compared with 11 controls in the follicular phase but no group differences were found in the late-luteal phase (12). Further, there were no differences in HRV between menstrual phases in women with PMDD.…”

Section: Introductionmentioning

confidence: 72%

“…Further, there were no differences in HRV between menstrual phases in women with PMDD. Based on these findings, the authors concluded that reduced HRV in patients with PMDD is not related to the occurrence of premenstrual symptoms (12). Matsumoto et al (13) measured spectral-domain components of HRV in women who had low (n = 11), moderate (n = 11), and high (n = 8) scores on a menstrual distress questionnaire.…”

Section: Introductionmentioning

confidence: 99%

“…These findings, therefore, suggest that women with moderate symptoms of PMS show altered HRV in association with their symptoms in the late-luteal phase. Given the findings of these two studies (12,13), there is a need to further investigate HRV in women with PMS and PMDD.…”

Section: Introductionmentioning

confidence: 99%

“…There are reports of increases in the LF/HF ratio, interpreted as indicating increased SNS activity (14-16), increased HF power, interpreted as indicating enhanced PNS activity (17), decreased SDNN and SDANN (12), or no change in time-domain (18) or spectral-domain (19) HRV components during the luteal phase compared with the follicular phase of the menstrual cycle.…”

Section: Introductionmentioning

confidence: 99%

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Reduced parasympathetic activity during sleep in the symptomatic phase of severe premenstrual syndrome

Baker

Colrain

Trinder

2008

Journal of Psychosomatic Research

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Objective-Severe premenstrual syndrome (PMS) is a common, distressing disorder in women that manifests during the premenstrual (late-luteal) phase of the ovulatory menstrual cycle. There is some evidence that altered autonomic function may be an important component of PMS but few studies have used heart rate variability (HRV), as a sensitive marker of autonomic activity, in severe PMS and findings are conflicting.Methods-We investigated HRV during sleep, a state relatively free of external disruptions, in nine women with severe PMS and twelve controls.Results-The normal-to-normal (NN) RR-interval was shorter during the sleep period in women with PMS than in controls in both the follicular and late-luteal phases of the menstrual cycle. The standard deviation of all NN intervals (SDNN), a measure of total variability in the inter-beat interval, was lower during the sleep period in the late-luteal phase than in the follicular phase in women with PMS. The square root of the mean of the sum of the squares of differences between adjacent NN intervals (rMSSD), a measure reflecting high frequency activity, showed a similar pattern. High frequency power, a marker of parasympathetic activity, was lower during non-rapid eye movement (non-REM) and REM sleep in the late-luteal phase than in the follicular phase in women with severe PMS. Controls had a shorter NN-interval, but similar HRV measures, in the late-luteal phase compared with the follicular phase.Conclusion-These results suggest that women with severe PMS have decreased parasympathetic activity during sleep in association with their premenstrual symptoms compared to when they are symptom-free.

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Section: Discussioncontrasting

confidence: 75%

Section: Introductionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reduced parasympathetic activity during sleep in the symptomatic phase of severe premenstrual syndrome

Baker

Colrain

Trinder

2008

Journal of Psychosomatic Research

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Posttraumatic stress disorder and trauma characteristics are correlates of premenstrual dysphoric disorder

Pilver

Levy²,

Libby

et al. 2011

Arch Womens Ment Health

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Posttraumatic stress disorder (PTSD) is often comorbid with premenstrual dysphoric disorder (PMDD) in women; however, it is unclear whether this relationship is driven by the trauma that may lead to PTSD or if PTSD is uniquely associated with PMDD. In this study, we examine trauma and PTSD as independent correlates of PMDD. Researchers conducted a cross-sectional, secondary data analysis of 3,968 female participants (aged 18–40) of the Collaborative Psychiatric Epidemiology Surveys. Women who had a history of trauma with PTSD (odds ratio, OR= 8.14, 95% confidence interval, CI=3.56–18.58) or a history of trauma without PTSD (OR=2.84, 95% CI=1.26–6.42) were significantly more likely than women with no history of trauma to report PMDD. This graded relationship was also observed in association with premenstrual symptoms. Among trauma survivors, PTSD was independently associated with PMDD, although characteristics of participants’ trauma history partially accounted for this association. Our study demonstrated that trauma and PTSD were independently associated with PMDD and premenstrual symptoms. Clinicians should be aware that women who present with premenstrual symptomatology complaints may also have a history of trauma and PTSD that needs to be addressed. This pattern of comorbidity may complicate the treatment of both conditions.

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Sympathetic skin response in premenstrual syndrome

et al. 2005

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Premenstrual syndrome is a term which includes a broad group of emotional, behavioral and physical symptoms that occur for several days before menses and subside following the menstrual period. Many women experience premenstrual syndrome symptoms, particularly physical ones such as breast tenderness and swelling. Approximately 5-10% women suffer from severe premenstrual syndrome and another 30-40% have moderate symptoms. Premenstrual syndrome continues to be an unsolved problem. In this study, we evaluated 24 premenstrual syndrome patients and 20 healthy women in the control group. The ages of the women were 22-34 years (mean +/- SD: 25+/-3) for the premenstrual syndrome group and 23-34 (25+/-3) for the control group. The sympathetic skin response was recorded from the palms, soles and genital regions by using electrical stimuli to the median nerve at the wrist. The sympathetic skin response was recorded twice, in the follicular and late luteal phases of menstruation. The follicular and late luteal phase sympathetic skin response of the two groups were compared. The amplitudes and latency values of the late luteal and follicular phase sympathetic skin response from the premenstrual syndrome group and control group women were statistically similar. We also did not find any latency or amplitude difference in the sympathetic skin response obtained from the three regions of the premenstrual syndrome patients and the control group. We checked sympathetic skin response in the symptomatic (late luteal phase) and asymptomatic (follicular phase) periods of patients with premenstrual syndrome, a disorder known to have many autonomic symptoms, to determine whether there was sudomotor sympathetic involvement. The results of our PMS patients indicate at the very least that there is no difference with the control subjects as regards peripheral sudomotor functions.

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Heart rate variability in premenstrual dysphoric disorder

Cited by 45 publications

References 62 publications

Reduced parasympathetic activity during sleep in the symptomatic phase of severe premenstrual syndrome

Reduced parasympathetic activity during sleep in the symptomatic phase of severe premenstrual syndrome

Posttraumatic stress disorder and trauma characteristics are correlates of premenstrual dysphoric disorder

Sympathetic skin response in premenstrual syndrome

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