Heart Rate Variability in Porcine Progressive Peritonitis-Induced Sepsis

Jarkovská, Dagmar; Valešová, Lenka; Chvojka, J; Beneš, Jan; Švíglerová, Jitka; Florova, Blanka; Nalos, Lukáš; Matějovič, Martin; Štengl, Milan

doi:10.3389/fphys.2015.00412

Cited by 16 publications

(41 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There was no premature death due to refractory septic shock; all animals were euthanized according to the original experimental time schedule > 40 h after induction of sepsis. This was very different from our traditional experimental scenario with higher dose of feces, in which refractory septic shock with lethal consequences usually developed within 24 h. 11…”

Section: Resultscontrasting

confidence: 66%

“…Although in none of our previous studies with the porcine peritonitis-induced sepsis model (e.g. Jarkovska et al 11 ) sex-specific differences in the response to the infection were observed, they cannot be completely excluded.…”

Section: Study Limitationsmentioning

confidence: 72%

“…Previously, we have shown that in the porcine model of peritonitis-induced progressive septic shock, HRV parameters are substantially and quickly reduced. 11 In this study the model was modified by decreasing the dose of feces and by administration of antibiotic therapy to prevent multiorgan failure. Analysis of organ dysfunction and tissue perfusion variables revealed that organ failure probably did not develop: diuresis increased during the experiment to values above 2 mL/kg/h; plasma levels of creatinine and bilirubin did not change throughout the experiment; and plasma levels of lactate slightly decreased during the experiment.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Heart-rate variability depression in porcine peritonitis-induced sepsis without organ failure

Jarkovská

Valešová

Chvojka

et al. 2017

Exp Biol Med (Maywood)

Self Cite

View full text Add to dashboard Cite

Depression of heart-rate variability (HRV) in conditions of systemic inflammation has been shown in both patients and experimental animal models and HRV has been suggested as an early indicator of sepsis. The sensitivity of HRV-derived parameters to the severity of sepsis, however, remains unclear. In this study we modified the clinically relevant porcine model of peritonitis-induced sepsis in order to avoid the development of organ failure and to test the sensitivity of HRV to such non-severe conditions. In 11 anesthetized, mechanically ventilated and instrumented domestic pigs of both sexes, sepsis was induced by fecal peritonitis. The dose of feces was adjusted and antibiotic therapy was administered to avoid multiorgan failure. Experimental subjects were screened for 40 h from the induction of sepsis. In all septic animals, sepsis with hyperdynamic circulation and increased plasma levels of inflammatory mediators developed within 12 h from the induction of peritonitis. The sepsis did not progress to multiorgan failure and there was no spontaneous death during the experiment despite a modest requirement for vasopressor therapy in most animals (9/11). A pronounced reduction of HRV and elevation of heart rate developed quickly (within 5 h, time constant of 1.97 ± 0.80 h for HRV parameter TINN) upon the induction of sepsis and were maintained throughout the experiment. The frequency domain analysis revealed a decrease in the high-frequency component. The reduction of HRV parameters and elevation of heart rate preceded sepsis-associated hemodynamic changes by several hours (time constant of 11.28 ± 2.07 h for systemic vascular resistance decline). A pronounced and fast reduction of HRV occurred in the setting of a moderate experimental porcine sepsis without organ failure. Inhibition of parasympathetic cardiac signaling probably represents the main mechanism of HRV reduction in sepsis. The sensitivity of HRV to systemic inflammation may allow early detection of a moderate sepsis without organ failure. Impact statement A pronounced and fast reduction of heart-rate variability occurred in the setting of a moderate experimental porcine sepsis without organ failure. Dominant reduction of heart-rate variability was found in the high-frequency band indicating inhibition of parasympathetic cardiac signaling as the main mechanism of heart-rate variability reduction. The sensitivity of heart-rate variability to systemic inflammation may contribute to an early detection of moderate sepsis without organ failure.

show abstract

Section: Resultscontrasting

confidence: 66%

Section: Study Limitationsmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Heart-rate variability depression in porcine peritonitis-induced sepsis without organ failure

Jarkovská

Valešová

Chvojka

et al. 2017

Exp Biol Med (Maywood)

Self Cite

View full text Add to dashboard Cite

show abstract

“…A recent report of a porcine model of septic peritonitis investigated the variations of HRV during septic shock . In this study, HRV was analyzed with various methods throughout the development of progressive hyperdynamic septic shock in 11 anesthetized pigs after inoculation of 1 g/kg of autologous feces into the abdominal cavity.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent experimental study investigating HRV in a porcine model of peritonitis‐induced septic shock, a reduction of the HF component and an increase in both the LF component and LF/HF ratio were observed after the onset of sepsis . These changes in HRV were associated with pronounced parasympathetic inhibition and a shift of sympathovagal balance toward sympathetic cardiac modulation.…”

Section: Introductionmentioning

confidence: 96%

Effects of esmolol on systemic hemodynamics and heart rate variability measured using the Analgesia/Nociception Index in resuscitated piglets with Pseudomonas aeruginosa septic shock

Boselli

Jacquet-Lagrèze

Ayoub

et al. 2018

J Vet Emergen Crit Care

View full text Add to dashboard Cite

show abstract

Autonomic and circulatory alterations persist despite adequate resuscitation in a 5-day sepsis swine experiment

Carrara

Antenucci

Liu

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Autonomic and vascular failures are common phenotypes of sepsis, typically characterized by tachycardia despite corrected hypotension/hypovolemia, vasopressor resistance, increased arterial stiffness and decreased peripheral vascular resistance. In a 5-day swine experiment of polymicrobial sepsis we aimed at characterizing arterial properties and autonomic mechanisms responsible for cardiovascular homeostasis regulation, with the final goal to verify whether the resuscitation therapy in agreement with standard guidelines was successful in restoring a physiological condition of hemodynamic profile, cardiovascular interactions and autonomic control. Twenty pigs were randomized to polymicrobial sepsis and protocol-based resuscitation or to prolonged mechanical ventilation and sedation without sepsis. The animals were studied at baseline, after sepsis development, and every 24 h during the 3-days resuscitation period. Beat-to-beat carotid blood pressure (BP), carotid blood flow, and central venous pressure were continuously recorded. The two-element Windkessel model was adopted to study carotid arterial compliance, systemic vascular resistance and characteristic time constant τ. Effective arterial elastance was calculated as a simple estimate of total arterial load. Cardiac baroreflex sensitivity (BRS) and low frequency (LF) spectral power of diastolic BP were computed to assess autonomic activity. Sepsis induced significant vascular and autonomic alterations, manifested as increased arterial stiffness, decreased vascular resistance and τ constant, reduced BRS and LF power, higher arterial afterload and elevated heart rate in septic pigs compared to sham animals. This compromised condition was persistent until the end of the experiment, despite achievement of recommended resuscitation goals by administered vasopressors and fluids. Vascular and autonomic alterations persist 3 days after goal-directed resuscitation in a clinically relevant sepsis model. We hypothesize that the addition of these variables to standard clinical markers may better profile patients’ response to treatment and this could drive a more tailored therapy which could have a potential impact on long-term outcomes.

show abstract

Heart Rate Variability in Porcine Progressive Peritonitis-Induced Sepsis

Cited by 16 publications

References 53 publications

Heart-rate variability depression in porcine peritonitis-induced sepsis without organ failure

Heart-rate variability depression in porcine peritonitis-induced sepsis without organ failure

Effects of esmolol on systemic hemodynamics and heart rate variability measured using the Analgesia/Nociception Index in resuscitated piglets with Pseudomonas aeruginosa septic shock

Autonomic and circulatory alterations persist despite adequate resuscitation in a 5-day sepsis swine experiment

Contact Info

Product

Resources

About