Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: A systematic review

Meeus, Mira; Goubert, Dorien; Backer, Fien De; Struyf, Filip; Hermans, Linda; Coppieters, Iris; Wandele, Inge De; Silva, Hellen Da; Calders, Patrick

doi:10.1016/j.semarthrit.2013.03.004

Cited by 170 publications

(160 citation statements)

References 48 publications

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“…It consists of 2 branches (sympathetic and parasympathetic), both of which exert antagonistic effects on most bodily functions and also contribute to homeostasis in the body. 12 Moreover, the autonomic nervous system is responsible for maintaining involuntary vital parameters, including blood pressure, heart rate, respiration, gastrointestinal secretions, and temperature control.…”

Section: Introductionmentioning

confidence: 99%

Evidence for Autonomic Function and Its Influencing Factors in Subjects With COPD: A Systematic Review

et al. 2015

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SummaryCardiovascular autonomic neuropathy is one of the factors implicated in the high morbidity and mortality rate in patients with COPD. Thus, several studies and nonsystematic reviews have increasingly reported autonomic function impairment in these subjects. For a better understanding, this systematic review was performed to evaluate not only the evidence for autonomic function impairment, but also factors influencing it. The results of the studies reviewed showed a strong level of evidence to support the impairment of heart rate variability in the time domain. A similar evidence level was also found to support impairment in baroreceptor sensitivity and muscle sympathetic nerve activity. Furthermore, this review identified physical activity level, muscle function, and circadian rhythm as the major influencing factors (strong evidence) of autonomic function in subjects with COPD. However, no definite conclusion could be reached for factors such as dyspnea, anxiety, body composition, pulmonary function, age, breathing frequency, ventilatory effort, quality of life, and disease severity due to limited, conflicting, or lack of existing evidence. The results of this review highlight relevant clinical messages for clinicians and other health-care providers regarding the role autonomic function can play as an important physiological marker for prognostication and stratification. Hence, autonomic function outcomes should be identified and considered during management of patients with COPD. Moreover, this review can serve as basis for future research aimed at assessing the interventions for autonomic function abnormalities in these patients.

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Section: Introductionmentioning

confidence: 99%

Evidence for Autonomic Function and Its Influencing Factors in Subjects With COPD: A Systematic Review

et al. 2015

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“…Patients with CFS commonly exhibit orthostatic intolerance, and abnormal sympathetic predominance in the autonomic cardiovascular response to gravitational stimuli was previously described (4). In addition, certain studies investigate the role of sympathetic activity in CFS patients via the analysis of heart rate variability; however, the results are inconclusive (5). Furthermore, a small left ventricular size with a low cardiac output was observed in patients with CFS, in whom orthostatic intolerance appears to be extremely common (6).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular characteristics of chronic fatigue syndrome

Beigrezaei

Albergati²,

Capelli

et al. 2017

biom rep

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Abstract.Patients with chronic fatigue syndrome (CFS) commonly exhibit orthostatic intolerance. Abnormal sympathetic predominance in the autonomic cardiovascular response to gravitational stimuli was previously described in numerous studies. The aim of the current study was to describe cardiological and clinical characteristics of Italian patients with CFS. All of the patients were of Caucasian ethnicity and had been referred to our center, the Cardiology Department of the University Hospital of Pavia (Pavia, Italy) with suspected CFS. A total of 44 patients with suspected CFS were included in the present study and the diagnosis was confirmed in 19 patients according to recent clinical guidelines. The characteristics at baseline of the population confirm findings from various previous reports regarding the prevalence in females with a female to male ratio of 4:1, the age of onset of the pathology and the presence of previous infection by the Epstein-Barr virus, cytomegalovirus and other human herpesviruses. Despite the current data indicating that the majority of the cardiological parameters investigated are not significantly different in patients with and without CFS, a significant association between the disease and low levels of blood pressure was identified. Other pilot studies revealed a higher prevalence of hypotension and orthostatic intolerance in patients with CFS. Furthermore, many of the CFS symptoms, including fatigue, vertigo, decreased concentration, tremors and nausea, may be explained by hypotension.

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“…En estos trabajos se han empleado diversos métodos para evaluar el SNA, entre ellos destaca el análisis de la variabilidad de la frecuencia cardiaca (VFC) (Meeus et al, 2013). La VFC es defi nida como la variación de la frecuencia del latido cardiaco durante un intervalo de tiempo determinado (nunca superior a 24 horas) y se mide habitualmente mediante el electrocardiograma (ECG) (Kulshreshtha y Deepak, 2013;McCraty, Atkinson, Tomasino y Bradley, 2009;Meeus et al, 2013).…”

Section: Introductionunclassified

“…La VFC es defi nida como la variación de la frecuencia del latido cardiaco durante un intervalo de tiempo determinado (nunca superior a 24 horas) y se mide habitualmente mediante el electrocardiograma (ECG) (Kulshreshtha y Deepak, 2013;McCraty, Atkinson, Tomasino y Bradley, 2009;Meeus et al, 2013). La VFC además de ser una medida de la regulación o funcionamiento autonómico, también proporciona información sobre la capacidad del SNA para organizar una respuesta homeostática de acuerdo con las demandas de la situación (Gómez-Alcaina, Montero-Marín, Demarzo, Pereira y García-Campayo, 2013; Serino et al, 2014;Staud, 2008).…”

Section: Introductionunclassified

“…Los estudios metanalíticos sobre la VFC en la FM concluyen que en la mayoría de las investigaciones desarrolladas encuentran una menor VFC en los sujetos con FM en comparación con los sanos (Meeus et al, 2013;del Paso et al, 2011;Tracy et al, 2016) y esta diferencia la interpretan como indicadora de una regulación autónoma global disminuida propia de la FM (Chalaye et al, 2012;da Cunha et al, 2011;Kulshreshtha y Deepak, 2013;Lerma et al, 2011). La alteración de la VFC en la FM, en comparación con los controles sanos, también se caracteriza por presencia a lo largo del sueño de hiperactividad simpática, hipoactividad parasimpática y menor VFC (Álvaro y Traver, 2010;Díaz-Piedra et al, 2014;Lerma et al, 2011;Sañudo et al, 2010).…”

Section: Introductionunclassified

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Disfunción del sistema autonómico y estado de salud percibido en la Fibromialgia

Lledó

Fernández-Díez

Pastor

et al. 2016

RPPC

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Resumen: En la actualidad se plantea que una alteración en el funcionamiento del sistema nervioso autónomo (SNA) podría está implicada en la cronifi cación de la sintomatología que presenta la fi bromialgia (FM). El objetivo de este estudio es comparar el funcionamiento del SNA mediante la evaluación de la variabilidad de la frecuencia cardiaca (VFC) entre mujeres con fi bromialgia y sanas, y analizar su relación con distintas dimensiones del estado de salud percibido. Los resultados confi rman que las mujeres con FM presentan una actividad parasimpática, hormonal y termorreguladora más disminuida que las mujeres sanas en situación de reposo; y la relación del desequilibrio del SNA (mediante el análisis de la VFC) con los síntomas más frecuentes en la FM, mientras que su relación con el estado de salud percibido queda pendiente de desarrollo.Palabras clave: Fibromialgia; sistema nervioso autónomo; variabilidad de la frecuencia cardiaca; síntomas; estado de salud percibido. Autonomic nervous system functioning and health in fi bromyalgiaAbstract: Presently it is proposed that an alteration of autonomic nervous system (ANS) functioning may be involved in the chronicity of fi bromyalgia (FM) symptoms. The aim of this study is to compare ANS activity by assessing the heart rate variability (HRV) between women with FM and healthy ones, and analyze its relationship with different dimensions of perceived health. The results confi rm that women with FM have a more diminished parasympathetic, hormonal and thermoregulatory activity than healthy women at rest; and the existing relationship of ANS imbalance (analyzed with HRV) with the most common FM symptoms, while its relationship with perceived health needs more development.

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Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: A systematic review

Cited by 170 publications

References 48 publications

Evidence for Autonomic Function and Its Influencing Factors in Subjects With COPD: A Systematic Review

Evidence for Autonomic Function and Its Influencing Factors in Subjects With COPD: A Systematic Review

Cardiovascular characteristics of chronic fatigue syndrome

Disfunción del sistema autonómico y estado de salud percibido en la Fibromialgia

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