Heart rate variability in patients with decompensated liver cirrhosis – a pilot study

Abstract

Introduction: Cirrhosis is associated with many disorders of the cardiovascular system defined "cirrhotic cardiomyopathy". They concern, among others autonomic imbalance. One of the ways to evaluate these disorders is to study the heart rate variability (HRV). Abnormal HRV values occur in hypertension, ischemic heart disease, post myocardial infarction and heart failure. Are one of the prognostic factors. Aim: Evaluation of parameters of HRV in 24-hour Holter monitoring in patients with decompensated cirrhosis. Material and methods: The study included 18 patients with decompensated cirrhosis and the control group consisted of 16 healthy subjects. Enrolled were performed 24-hour Holter ECG. Heart rate variability parameters, were estimated during whole recording period, separately for night resting and morning activity hours. Results: There have been significant differences in almost all, both time and frequency HRV parameters between the two groups for follow-up clock. Similar results were obtained by comparing the HRV separately for the night and morning with a control group. The control group achieved statistically significant differences between all the time parameters of HRV at night compared with morning. Frequency parameters showed no significant differences. In patients with cirrhosis demonstrated such differences for the average time NN, SDNN, SDANN, Tr-I, Tinn and ULF. In a 24-hour observation of HRV parameters did not differ significantly depending on the grade in Child-Pugh classification. Conclusions: Patients with decompensated cirrhosis showed significantly lower HRV parameters than healthy volunteers. In addition, disturbances of circadian distribution showed

The use of heart rate turbulence and heart rate variability in the assessment of autonomic regulation and circadian rhythm in patients with systemic lupus erythematosus without apparent heart disease

“…Disorders of diurnal variation HRV are typical of many diseases including diabetes and diabetic neuropathy, 38 alcoholic neuropathy 39 or liver cirrhosis. 29 In our study, we confirmed the change in HRV parameters depending on the time of day in the control group of healthy people. In daytime, the values of corresponding sympathetic activity were significantly higher, including SDANN and TrI, and in night resting hours – parasympathetic – r-MSSD, p50NN and HF band.…”

Cardiovascular risk assessment by electrocardiographic Holter monitoring in patients with chronic hepatitis C

“…It is in line with our earlier studies. In those studies, we demonstrated a similar profile of autonomic disorders in patients with cirrhosis decompensation [ 40 ]. The parasympathetic system characterising parameters were also significantly lower in that particular case.…”

Non-Alcoholic Cirrhosis and Heart Rate Variability: A Systematic Mini-Review

“…Cirrhosis induces hemodynamic disturbances, peripheral nerve disorders, electromechanical conjunction, and dysfunction in the autonomic nervous system (ANS), and these occur independently of the etiology [12]. The liver is innervated with many branches of the ANS.…”

“…Primary Biliary Cholangitis (PBC) is associated with other pathologies, and is known as cirrhotic cardiomyopathy when it is associated with cardiovascular disturbances. A decreased HRV is correlated with cirrhosis and vascular changes [12]. There is evidence showing the myocardial repolarization lability is significantly altered in end-stage liver disease [21].…”