Heart rate variability in normal and complicated pregnancies

Khlybova, Svetlana; Tsirkin, V. I.; Dvoryanskii, S. A.; Makarova, I. A.; Трухин, А. Н.

doi:10.1134/s0362119708050113

Cited by 15 publications

(9 citation statements)

References 12 publications

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“…Thus, for estrus and proestrus phase (n = 15), i.e. with the dominance of estrogen [20] "wet" mass was 88 (75; 116) mg and the "dry" mass was 20 (18,26) mg. For metaestrus and diestrus phase (n = 15), i.e. progesterone dominance these values were respectively 100 (84; 130) and 22 mg (20; 30) mg (difference from rats in proestrus and estrus phase, not statistically signi icant, p> 0.05 M-W ).…”

Section: Mass Of Myocardial Stripsmentioning

confidence: 94%

“…It is known [24,25], that the heart rate variability (HRV), which re lects the adrenoreactivity and cholinoreaktivity of myocardium in women during pregnancy signi icantly reduced [8,22,[26][27][28]. It is believed to be due to the increase in sympathetic effects on the heart [28], or high content in blood of endogenous sensitizer of betaadrenoceptors (ESBAR), which increases the effectiveness of the activation of beta-AR of myocardium, i. e increases of myocardial adrenoreactivity [8,26,27].…”

Section: Adrenoreactivity Of Rat Myocardiummentioning

confidence: 99%

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Influence of histidine on the contractility and adrenaline inotropic effect in the experiments with myocardium of right ventricular of Non pregnant and Pregnant Rats

Tsirkin¹,

Nozdrachev²,

Korotaeva³

et al. 2018

J Cardiol Cardiovasc Med

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It was investigated contractility and adrenoreactivity of intact myocardium strips of right ventricular in experiment with 60 rats. They were assessed by the force of induce contraction and its changes under the infl uence of adrenaline (10-9 or 10-5 g / ml). Found that these indicators do not depend on the phases of the estrous cycle and the presence of pregnancy. Histidine (10-10-10-4 g / ml) did not increase the response to adrenalin (10-9 g / ml), but increased the force of the contractions in rats in progesterone dominance (trend) and pregnancy (statistically signifi cant). Against the background of propranolol (10-8 g / mL) or atenolol (10-8 , 10-6 g / mL), adrenaline (10-5 g / mL) instead of increasing the force of contraction reduced it (probably due to activation of beta 3-, alpha 1-and alpha 1 a2-adrenergic receptors), and histidine (10-4 g / mL) prevented this reduction, but does not restore full ability of adrenaline to exert a positive inotropic effect. On the background of nicergoline (10-8 g / mL or nicergoline and propranolol (10-8 g / mL), adrenaline (10-5 g / mL) did not alter the force of contraction, and histidine (10-4 g/mL) restore ability of adrenaline to exert a positive inotropic effect but only in the experiments with nicergoline. Concluded that histidine increases the effi ciency of the activation of all three (beta 1-, beta 2-and beta 3-) populations of myocardial beta-adrenoceptoprs, including at lower by adrenergic blockers. Therefore, histidine proposed as an antagonist of beta-adrenergic blockers and as resensitizator of these receptors. Core Tip: In the experiments with strips of the right ventricle of 40 nonpregnant and 20 pregnant rats histidine (10-10-10-4 g /mL) did not increase the response to adrenaline (10-9 g / ml), but increased the force of contractions in pregnant rats. On the background of propranolol (10-8 g / mL) or atenolol (10-8 , 10-6 g / mL), adrenaline (10-5 g/mL) showed a negative inotropic effect, and histidine (10-4 g / mL) prevented it, but does not restore the ability of adrenaline to show positive inotropic effect,. i.e histidine exhibits the properties of the antagonist of beta-blockers and of resensitizator of beta-adrenoceptors.

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Section: Mass Of Myocardial Stripsmentioning

confidence: 94%

Section: Adrenoreactivity Of Rat Myocardiummentioning

confidence: 99%

Influence of histidine on the contractility and adrenaline inotropic effect in the experiments with myocardium of right ventricular of Non pregnant and Pregnant Rats

Tsirkin¹,

Nozdrachev²,

Korotaeva³

et al. 2018

J Cardiol Cardiovasc Med

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“…The main mechanisms mediating these changes are related to the endocrine and the autonomic nervous systems (ANS) [ 2 , 4 ]. However, in some cases, the ANS does not sufficiently adapt to support the increasing demands of pregnancy—a scenario which is associated with various pregnancy complications [ 5 ]. Two prominent examples are hypertensive disorders of pregnancy (HDP) and preterm birth (PTB), both of which are leading causes of worldwide perinatal and maternal morbidity and mortality [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The early detection of these conditions is important and actionable since effective risk-mitigating interventions do exist [ 10 , 11 , 12 ]. Although their exact etiologies remain uncertain, studies indicate that both complications are associated with dysfunctional autonomic regulation [ 5 , 13 , 14 , 15 , 16 ]. A prominent theory is that this autonomic dysfunction results in insufficient placental development in early pregnancy, which in turn results in the development of such complications [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Since changes in HR are closely modulated by the ANS, studying HR and, in particular, its variability offers a window into changes in autonomic activity [ 17 , 20 , 21 , 22 ]. Consequently, maternal heart rate variability (mHRV) has been increasingly studied to assess autonomic dysfunction in complicated pregnancies [ 5 , 17 , 19 , 20 , 23 , 24 , 25 ]. However, such studies, which are typically performed in pregnancies leading to hospitalization, have generated conflicting findings [ 17 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Changes in Maternal Heart Rate Variability in Response to the Administration of Routine Obstetric Medication in Hospitalized Patients: Study Protocol for a Cohort Study (MAMA-Heart Study)

Bester

Moors

Joshi

et al. 2021

Clinics and Practice

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Pregnancy is a period of continuous change in the maternal cardiovascular system, partly mediated by the autonomic nervous system. Insufficient autonomic adaptation to increasing gestation is associated with pregnancy complications, such as hypertensive disorders of pregnancy and preterm birth (both major causes of perinatal morbidity and mortality). Consequently, maternal heart rate variability (mHRV), which is a proxy measure for autonomic activity, is increasingly assessed in these cohorts to investigate the pathophysiology of their complications. A better pathophysiological understanding could facilitate the early detection of these complications, which remains challenging. However, such studies (typically performed in pregnancies leading to hospitalization) have generated conflicting findings. A probable reason for these conflicting findings is that these study cohorts were likely administered routine obstetric medications during the study period of which the effects on mHRV are largely unknown. Subsequently, we design a longitudinal, observational study to quantifying the effect of these medications—particularly corticosteroids, which are known to affect fetal HRV—on mHRV to improve the interpretation of past and future studies. We will enroll 61 women admitted to a tertiary obstetric unit with an indication to receive corticosteroids antenatally. Participants’ mHRV will be continuously acquired throughout their hospitalization with wrist-worn photoplethysmography to facilitate a within-patient comparison of the effect of corticosteroids on mHRV.

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Identifying psychophysiological stress targets for the promotion of mental health in pregnant women

Herbell

2019

Archives of Psychiatric Nursing

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Heart rate variability in normal and complicated pregnancies

Cited by 15 publications

References 12 publications

Influence of histidine on the contractility and adrenaline inotropic effect in the experiments with myocardium of right ventricular of Non pregnant and Pregnant Rats

Influence of histidine on the contractility and adrenaline inotropic effect in the experiments with myocardium of right ventricular of Non pregnant and Pregnant Rats

Changes in Maternal Heart Rate Variability in Response to the Administration of Routine Obstetric Medication in Hospitalized Patients: Study Protocol for a Cohort Study (MAMA-Heart Study)

Identifying psychophysiological stress targets for the promotion of mental health in pregnant women

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