Heart rate variability in healthy young adults exposed to global system for mobile communication (GSM) 900-MHz radiofrequency signal from mobile phones

Wallace, Jasmina; Andrianome, Soafara; Ghosn, Rania; Blanchard, Erwan Stephan; Telliez, Frédéric; Selmaoui, Brahim

doi:10.1016/j.envres.2020.110097

Cited by 5 publications

(1 citation statement)

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“…The health risk assessment of non-ionizing electromagnetic radiation generated science and policy debates for decades, particularly around the health effects of radiofrequency radiation (RFR) in the 3 kHz to 300 GHz frequency range used for wireless communications [1][2][3][4]. Among the reported biological effects of electromagnetic fields are harm to fetal growth and development [5][6][7][8][9][10][11][12][13], changes in heart rate variability [14,15], changes in brain activity [16,17], and elevated risk of several cancers [18][19][20][21]. In 2011, the International Agency for Research on Cancer (IARC) classified radiofrequency electromagnetic fields as "possibly carcinogenic to humans" based on an increased risk of glioma, a malignant brain cancer, associated with cellular phone use [18].…”

Section: Introductionmentioning

confidence: 99%

Development of health-based exposure limits for radiofrequency radiation from wireless devices using a benchmark dose approach

Uche

Naidenko

2021

Environ Health

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Background Epidemiological studies and research on laboratory animals link radiofrequency radiation (RFR) with impacts on the heart, brain, and other organs. Data from the large-scale animal studies conducted by the U.S. National Toxicology Program (NTP) and the Ramazzini Institute support the need for updated health-based guidelines for general population RFR exposure. Objectives The development of RFR exposure limits expressed in whole-body Specific Absorption Rate (SAR), a metric of RFR energy absorbed by biological tissues. Methods Using frequentist and Bayesian averaging modeling of non-neoplastic lesion incidence data from the NTP study, we calculated the benchmark doses (BMD) that elicited a 10% response above background (BMD10) and the lower confidence limits on the BMD at 10% extra risk (BMDL10). Incidence data for individual neoplasms and combined tumor incidence were modeled for 5% and 10% response above background. Results Cardiomyopathy and increased risk of neoplasms in male rats were the most sensitive health outcomes following RFR exposures at 900 MHz frequency with Code Division Multiple Access (CDMA) and Global System for Mobile Communications (GSM) modulations. BMDL10 for all sites cardiomyopathy in male rats following 19 weeks of exposure, calculated with Bayesian model averaging, corresponded to 0.27–0.42 W/kg whole-body SAR for CDMA and 0.20–0.29 W/kg for GSM modulation. BMDL10 for right ventricle cardiomyopathy in female rats following 2 years of exposure corresponded to 2.7–5.16 W/kg whole-body SAR for CDMA and 1.91–2.18 W/kg for GSM modulation. For multi-site tumor modeling using the multistage cancer model with a 5% extra risk, BMDL5 in male rats corresponded to 0.31 W/kg for CDMA and 0.21 W/kg for GSM modulation. Conclusion BMDL10 range of 0.2—0.4 W/kg for all sites cardiomyopathy in male rats was selected as a point of departure. Applying two ten-fold safety factors for interspecies and intraspecies variability, we derived a whole-body SAR limit of 2 to 4 mW/kg, an exposure level that is 20–40-fold lower than the legally permissible level of 0.08 W/kg for whole-body SAR under the current U.S. regulations. Use of an additional ten-fold children’s health safety factor points to a whole-body SAR limit of 0.2–0.4 mW/kg for young children.

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