Heart rate variability in familial Mediterranean fever patients

Kaya, Hakan; Süner, Arif; Köroğlu, Sedat; Akçay, Ahmet; Türkbeyler, İbrahim Halil; Koleoglu, Murat

doi:10.5152/eurjrheumatol.2014.013

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…Moreover, the HRV measurement is one of the best methods that evaluate the relationship between ANS and cardiovascular system quantitatively. 6 The HRV is defined as beat-to-beat variability in heart rate. The leading cause of HRV is autonomic tonus alterations.…”

Section: Discussionmentioning

confidence: 99%

“…Highly variable heart rates are a sign of good autonomic control. [4][5][6] The HRV is assessed by time and frequencydomain variables. There is a general agreement that the high-frequency band (HF) reflects parasympathetic activity and low-frequency band (LF) reflects both parasympathetic and sympathetic activity.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 It is important to assess the autonomic functions in SLE as some studies proposed that the autonomic fluctuations might predispose to ventricular arrhythmias and circulatory dysfunction. 6,7 Both sympathetic and parasympathetic pathways are associated with acute and chronic inflammation and autonomic dysfunction in SLE. There are reports suggesting that patients with SLE without clinically apparent cardiac symptoms have impaired autonomic function, primarily in the form of increased sympathetic and decreased parasympathetic activity.…”

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confidence: 99%

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Heart rate variability in juvenile systemic lupus erythematosus patients

Başaran¹,

Çetin²,

Aydın³

et al. 2019

Turk J Pediatr

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Although neurological involvement has been well recognized in patients with systemic lupus erythematosus (SLE), autonomic nervous system (ANS) involvement has rarely been studied, and has shown conflicting results. The aim of this study was to evaluate the ANS functions by using heart rate variability (HRV) in juvenile patients with SLE. Sixteen juvenile-onset SLE patients and 16 healthy controls were enrolled in the study. All participants underwent 24-hour Holter electrocardiogram monitoring and HRV indices were assessed. The SLE disease activity index (SLEDAI) score was used to assess the disease activity. We analyzed the correlation between disease duration, the SLEDAI score, and the HRV domains. Overall HRV was diminished in patients with SLE compared to controls. There were negative correlations between day and night RMSSD (root-mean-square of the successive normal sinus NN interval differences) and PNN50 (percentage of successive normal sinus NN intervals >50 ms) values, and SLEDAI (r=-0.588 p=0.017; r=-0.607 p= 0.013; r=-0.498 p=0.049; r=-0.597 p=0.015, respectively). There were positive correlations between both day and night LF/HF values and SLEDAI (r=0.766 p=0.001; r=0.635 p=0.008, respectively). The results suggest that autonomic dysfunction exists in juvenile patients with SLE. As these children are at increased risk for cardiovascular disease, they need to be assessed for the development of autonomic dysfunction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Heart rate variability in juvenile systemic lupus erythematosus patients

Başaran¹,

Çetin²,

Aydın³

et al. 2019

Turk J Pediatr

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“…Although the authors attributed these changes to the inflammatory feature of the disease, they did not discuss whether Col would affect these results (67). However, contrary to these studies, some studies did not detect a problem related to dysautonomia in FMF patients (70,71). The results in the clinical studies are inconsistent with each other because of the heterogeneity of demographic characteristics, differences in Col dose, and other disease characteristics of FMF patients.…”

Section: The Effect Of Colchicine On the Peripheral Nervous System An...mentioning

confidence: 95%

A Hypothesis Regarding Neurosecretory Inhibition of Stress Mediators by Colchicine in Preventing Stress-Induced Familial Mediterranean Fever Attacks

Korkmaz

Cansu²

2022

Front. Immunol.

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Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease characterized by recurrent episodes of fever and serositis. Colchicine (Col) has a crucial role in the prevention of amyloidosis and FMF attacks. The effect of Col on innate immune cells is based on the inhibition of the microtubule system. The microtubule system is also very important for neurosecretory functions. The inhibitory effect of Col on neurosecretory functions is an overlooked issue. Considering that the neuroimmune cross-talk process plays a role in the development of inflammatory diseases, the effect of Col on the neuronal system becomes important. FMF attacks are related to emotional stress. Therefore, the effect of Col on stress mediators is taken into consideration. In this hypothetical review, we discuss the possible effects of Col on the central nervous systems (CNS) and peripheral nervous systems (PNS) in light of mostly experimental study findings using animal models. Studies to be carried out on this subject will shed light on the pathogenesis of FMF attacks and the other possible mechanisms of action of Col apart from the anti-inflammatory features.

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“…[14] The HRV is evaluated by two ways: time domain analysis and frequency domain analysis. [15] VLF, LF, HF power are usually measured in absolute values of power (milliseconds squared [ms 2 ]). LF and HF can be also measured in normalized units (nu) to emphasize the controlled and balanced behavior of the two branches of the autonomic nervous system, as well as baroreflex responsiveness to beat-to-beat variation in arterial blood pressure.…”

Section: Introductionmentioning

confidence: 99%