Heart rate variability in drug-naïve patients with panic disorder and major depressive disorder

Kikuchi, Mitsuru; Hanaoka, Akira; Kidani, Tomokazu; Remijn, Gerard B.; Minabe, Yoshio; Munesue, Toshio; Koshino, Yoshifumi

doi:10.1016/j.pnpbp.2009.08.002

Cited by 37 publications

(23 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They did found some evidence of less "vagal decline" in patients who were depressed. Kikuchi et al (2009) found no difference in lnLF or lnHF between controls, panic disorder and major depressive disorder patients at rest.…”

Section: Hrv In Depressed Patients Without Cvdmentioning

confidence: 56%

Depression, heart rate related variables and cardiovascular disease

Taylor

2010

International Journal of Psychophysiology

115

View full text Add to dashboard Cite

Section: Hrv In Depressed Patients Without Cvdmentioning

confidence: 56%

Depression, heart rate related variables and cardiovascular disease

Taylor

2010

International Journal of Psychophysiology

115

View full text Add to dashboard Cite

“…These latter indices represent the response to the manoeuvre and are especially sensitive measures of autonomic modulation, extensively used in HRV studies (e.g. [88], [101]–[105]) because they explore the dynamic range of the ANS [37], [88].…”

Section: Methodsmentioning

confidence: 99%

Autonomic Dysfunction in Mild Cognitive Impairment: Evidence from Power Spectral Analysis of Heart Rate Variability in a Cross-Sectional Case-Control Study

et al. 2014

View full text Add to dashboard Cite

BackgroundMild cognitive impairment (MCI) is set to become a major health problem with the exponential ageing of the world's population. The association between MCI and autonomic dysfunction, supported by indirect evidence and rich with clinical implications in terms of progression to dementia and increased risk of mortality and falls, has never been specifically demonstrated.AimTo conduct a comprehensive assessment of autonomic function in subjects with MCI by means of power spectral analysis (PSA) of heart rate variability (HRV) at rest and during provocative manoeuvres.MethodsThis cross-sectional study involved 80 older outpatients (aged ≥65) consecutively referred to a geriatric unit and diagnosed with MCI or normal cognition (controls) based on neuropsychological testing. PSA was performed on 5-minute electrocardiographic recordings under three conditions—supine rest with free breathing (baseline), supine rest with paced breathing at 12 breaths/minute (parasympathetic stimulation), and active standing (orthosympathetic stimulation)—with particular focus on the changes from baseline to stimulation of indices of sympathovagal balance: normalized low frequency (LFn) and high frequency (HFn) powers and the LF/HF ratio. Blood pressure (BP) was measured at baseline and during standing. Given its exploratory nature in a clinical population the study included subjects on medications with a potential to affect HRV.ResultsThere were no significant differences in HRV indices between the two groups at baseline. MCI subjects exhibited smaller physiological changes in all three HRV indices during active standing, consistently with a dysfunction of the orthosympathetic system. Systolic BP after 10 minutes of standing was lower in MCI subjects, suggesting dysautonomia-related orthostatic BP dysregulation.ConclusionsOur study is novel in providing evidence of autonomic dysfunction in MCI. This is associated with orthostatic BP dysregulation and the ongoing follow-up of the study population will determine its prognostic relevance as a predictor of adverse health outcomes.

show abstract

“…Although reduced cardiac vagal modulation is a common finding in adult patients with depression (Kikuchi et al, 2009;Udupa et al, 2007), other studies reported unchanged parasympathetic activity (Bär et al, 2004). It seems that the heart rate variability analysis may contribute to early diagnosis of latent and clinically asymptomatic symptoms of a potential cardiac neural dysregulation associated with depression.…”

Section: Depressive Disordermentioning

confidence: 99%