Heart rate variability and severe brain damage: preliminary data

Lacquaniti, L; Irone, Marco; Barbacini, S.; Merlo, F; Garzino-Demo, Paolo; Pellegrin, Carlo; Dan, Maurizio

doi:10.1007/bf01246453

Cited by 16 publications

(2 citation statements)

References 9 publications

(10 reference statements)

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“…Studies by Crus-Rojas et al and Saucedo-Vence et al also reported that acesulfame K and sucralose increase the oxidative activity in the brain of common carp [ 5 , 80 ]. Heart rate is controlled by signals from the brain, therefore, damage in the brain may cause alterations in heart rate regulation [ 81 , 82 , 83 ]. A previous study in common carp also suggested lower antioxidant capacity after sucralose exposure [ 84 ].…”

Section: Discussionmentioning

confidence: 99%

Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae

Saputra

Lai

Fernández

et al. 2021

Biology

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Artificial sweeteners are widely used food ingredients in beverages and drinks to lower calorie intake which in turn helps prevent lifestyle diseases such as obesity. However, as their popularity has increased, the release of artificial sweetener to the aquatic environment has also increased at a tremendous rate. Thus, our study aims to systematically explore the potential cardiovascular physiology alterations caused by eight commercial artificial sweeteners, including acesulfame-K, alitame, aspartame, sodium cyclamate, dulcin, neotame, saccharine and sucralose, at the highest environmentally relevant concentration on cardiovascular performance using zebrafish (Danio rerio) as a model system. Embryonic zebrafish were exposed to the eight artificial sweeteners at 100 ppb and their cardiovascular performance (heart rate, ejection fraction, fractional shortening, stroke volume, cardiac output, heartbeat variability, and blood flow velocity) was measured and compared. Overall, our finding supports the safety of artificial sweetener exposure. However, several finding like a significant increase in the heart rate and heart rate variability after incubation in several artificial sweeteners are noteworthy. Biomarker testing also revealed that saccharine significantly increase the dopamine level in zebrafish larvae, which is might be the reason for the cardiac physiology changes observed after saccharine exposure.

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Section: Discussionmentioning

confidence: 99%

Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae

Saputra

Lai

Fernández

et al. 2021

Biology

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show abstract

“…In previous study, zebrafish treated with saccharin also exhibited infiltration of inflammatory cells into zebrafish liver and brain by increasing cholesteryl ester transfer protein, which play an important role in transporting and exchange of cholesteryl ester to triglyceride and vice versa [20]. Heart rate is controlled by signals from the brain, therefore, damage in the brain may cause alterations in heart rate regulation [69][70][71].…”

Section: Saccharin Induces Distinct Cardiac Performance In Zebrafish mentioning

confidence: 94%

In vivo Modelling of Toxicity of Eight Commercial Artificial Sweeteners in Daphnia Neonates and Zebrafish Embryos through Cardiac Performance Assessments

Saputra¹,

Lai²,

Fernández³

et al. 2020

Preprint

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Artificial sweeteners are widely used food ingredients in beverages and drinks to lower calorie intake which in turn prevent lifestyle diseases such as obesity. Epidemiological evidences suggest that an overdose of artificial sweeteners could result to adverse effects after consumption. Thus, our study aims to systematically explore the potential adverse effects of eight commercial artificial sweeteners, including acesulfame-K, alitame, aspartame, sodium cyclamate, dulcin, neotame, saccharin and sucralose on cardiac performances of zebrafish (Danio rerio) and Daphnia as model animals. Embryonic zebrafish and Daphnia were exposed to eight artificial sweeteners at 100 ppb concentrations and their cardiac performance (heart rate, ejection fraction, fractional shortening, stroke volume, cardiac output and heartbeat regularity) were measured and compared. Saccharin significantly increased the heart rate of zebrafish larvae while a significant decrease was observed in Daphnia. Significant increase was also noted in zebrafish heart rate variability after incubation in acesulfame K, dulcin, sodium cyclamate, and sucralose. However, a significant increase in Daphnia was only observed after incubation in dulcin. Based on Principal Component Analysis (PCA) and hierarchical clustering results, several artificial sweetener samples were species-specific to zebrafish and Daphnia. Our study demonstrates the potential adverse physiological effects of artificial sweeteners in cardiovascular systems of zebrafish larvae and Daphnia.

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Current clinical applications of heart rate variability

Styś

Styŝ

1998

Clinical Cardiology

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Summary:Heart rate variability (HRV) has become a popular method for the studies of physiologic mechanisms responsible for the control of heart rate fluctuations. in which the autonomic nervous system appears to play a primary role. Depression of HRV has been observed in many clinical scenarios. including autonomic neuropathy. heart transplantation, congestive heart failure, myocardial infarction (MI), and othct cardiac and noncardiac diseases. However, it is important to realize that clinical implication of HRV analysis has been clearly recognized in only two clinical conditions: ( 1 ) as a ptcdictor of risk of arrhythniic events or sudden cardiac death after acute MI, and ( 2 ) as a clinical marker of evolving diabetic neuropathy. Recently, its role in evaluation and nianagenient of heart failure has also been recognized. It is pertinenl to recognize the limitations of HRV ;IS far as its clinical utility at present is concerned. The methodology of HRV had remoined poorly standardized until the recent publication of the Special Repon of the Task Force of ESC/NASPE. and thus has been presenting difficulty in comparing earlier existing data. Also, determination of the exact sensitivity. specificity, and predictive value of HRV, as well as the normal values of standard measures in the general population, still require further investigation before better standards can be set for existing and future clinical applications. This article review\ the major concepts of HRV measurements. their clinical relevance, and the recent advances in this field.

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Heart rate variability and severe brain damage: preliminary data

Cited by 16 publications

References 9 publications

Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae

Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae

In vivo Modelling of Toxicity of Eight Commercial Artificial Sweeteners in Daphnia Neonates and Zebrafish Embryos through Cardiac Performance Assessments

Current clinical applications of heart rate variability

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