Heart rate variability and heart rate recovery in lung cancer survivors eligible for long-term cure

Abstract

A B S T R A C TLung cancer survivors are at risk for physical fitness and autonomic function impairments. In a cross-sectional study of consecutive lung cancer survivors post-curative intent therapy, we assessed and identified predictors of resting heart rate variability (HRV) and heart rate recovery (HRR), defined as standard deviation of normal-tonormal-R-to-R intervals (SDNN) and root-mean-square-of-successive-differences (rMSSD) from routine outpatient single 10-s electrocardiographs (ECGs) and difference in heart rate (HR) at 1-minute following and the end of the six-minute-walk-test (6MWT), respectively. In 69 participants, the mean (SD) HRR was -10.6 (6.7) beats. Significant independent predictors of HRR were age and HR change associated with the 6MWT. In a subset of 41 participants with available ECGs, the mean (SD) SDNN and rMSSD were 19.1 (15.6) and rMSSD 18.2 (14.6) ms, respectively. Significant independent predictors of HRV were supine HR, HRR, and total lung capacity. HRV/ HRR may be useful physiological measures in studies aimed at improving physical fitness and/or autonomic function in lung cancer survivors.Abbreviations: 6MWD, six-minute walk distance; 6MWT, six-minute walk test; ATS, American Thoracic Society; CAD, coronary artery disease; CI, confidence interval; COPD, chronic obstructive pulmonary disease; DL CO , diffusion capacity of the lung for carbon monoxide; DM, diabetes mellitus; ECG, electrocardiograph; FEV 1 , forced expiratory volume in 1 second; HR, heart rate; HRR, heart rate recovery; HRV, heart rate variability; MVA, multivariable linear regression analysis; NSCLC, non-small cell lung cancer; O 2 , oxygen; PAC, premature atrial contraction; PVC, premature ventricular contraction; QoL, quality of life; rMSSD, root mean square of successive differences; RPE, ratings of perceived exertion; SDNN, standard deviation of normal-to-normal R-R intervals; TLC, total lung capacity; UVA, univariable linear regression analysis; VASDHS, VA San Diego Healthcare System ⁎

Relationship between Heart Rate Variability and Functional Fitness in Breast Cancer Survivors: A Cross-Sectional Study

“…Vigo et al (2015) [ 18 ] confirmed the need to investigate the relationship between physical exercise and ANS to define personalized programs of secondary preventions for this population. In this sense, a previous study [ 60 ] analyzed lung cancer survivors and found no correlations between SDNN, RMSSD, and the “6MWT”. In the present study, we found no correlations for any HRV parameters with the “6MWT”.…”

Toward Modernization of Geriatric Oncology by Digital Health Technologies

“…Modern BioMeTs contain additional information that can help to correct for this. For example, resting heart rate, heart rate response to activity increases or decreases, respiratory variation as a function of heart rate and activity, and other physiologic data are related to physical function, 43,44 are obtainable from BioMeTs, 45 and could be included within a BioMeTderived physical function measure. Furthermore, other types of clinical outcomes assessments may also provide nonoverlapping data to give additional precision around physical function assessment, such as self-reported physical function (e.g., PROMIS 46,47 ), or the results of periodic standardized physical assessments, such as a 6-minute walk test 48 or short physical performance battery.…”

Correlation between Heart rate recovery and Left Atrial phasic functions evaluated by 2D speckle-tracking Echocardiography after Acute Myocardial infarction

“…[ 14 – 16 ] Heart rate variability (HRV) is another marker of cardiac autonomic system function and is evaluated by electrocardiography monitoring. Although the association between HRR and HRV has been presented in some studies, this association is not strong [ 17 , 18 ], which may suggest different aspects of cardiac autonomic system function assessed by these markers. [ 19 ] HRV is associated with LA phasic functions in patients with hypertension and diabetes.…”