Heart Rate Variability and Gastric Electrical Response to a Cold Pressor Task in Youth with Functional Dyspepsia

Luna, Francisco Miguel Vargas; Huerta-Franco, María Raquel; Schurman, Jennifer Verrill; Deacy, Amanda D; Bagherian, Amber; Harvey, Lisa; Friesen, Craig A.

doi:10.1007/s10620-019-05848-4

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…2). One article also presented the pre- and post-stimulus results arising from a “cold pressor task” stimulus in patients with FD (Supplemental Digital Content 8, http://links.lww.com/MPG/C317 ) (42). Correlation between patient symptoms and EGG outcome measures were performed in 7 articles reporting on FD.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 16 clinical disorders were investigated in the retrieved articles, constituting functional dyspepsia (FD) (25,26,31,(34)(35)(36)(37)(38)(39)(40)(41)(42)(43), gastro-esophageal reflux disease (GERD) (28)(29)(30)32,33,39), idiopathic nausea (44,45), type 1 diabetes mellitus (T1DM) (15,24,46,47), eating disorders (including anorexia nervosa) (38), structural GI disorders (infantile hypertrophic pyloric stenosis, esophagitis, and gastritis/duodenitis) (29,48,49), muscular dystrophies (14), multisystem disorders (cystic fibrosis and Noonan syndrome) (16,50,51), infant colic (52), cow's milk protein allergy (CMPA) (32), chronic intestinal pseudo-obstruction (CIPO) (27), and malignancy (53). The diagnostic criteria for disorders and exclusion criteria of each included article are outlined in Supplemental Digital Content 6, http://links.lww.com/MPG/C315.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Electrogastrography Abnormalities in Pediatric Gastroduodenal Disorders

Bhat

Varghese²,

Carson³

et al. 2021

J. pediatr. gastroenterol. nutr.

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Electrogastrography (EGG) is a non-invasive method of measuring gastric electrophysiology. Abnormal gastric electrophysiology is thought to contribute to disease pathophysiology in patients with gastroduodenal symptoms but this has not been comprehensively quantified in pediatric populations. This study aimed to quantify the abnormalities in gastric electrophysiology on EGG in neonatal and pediatric patients. Databases were systematically searched for articles utilizing EGG in neonatal and pediatric patients ( 18 years). Primary outcomes were prevalence of abnormality, percentage of time in normal rhythm, and power ratio. Secondary outcomes were correlations between patient symptoms and abnormal gastric electrophysiology on EGG. A total of 33 articles (1444 participants) were included. EGG methodologies were variable. Pooled prevalence of abnormalities on EGG ranged from 61% to 86% in patients with functional dyspepsia (FD), gastro-esophageal reflux disease (GERD), and type 1 diabetes mellitus (T1DM). FD patients averaged 20.8% (P ¼ 0.011) less preprandial and 21.6% (P ¼ 0.031) less postprandial time in normogastria compared with controls. Electrophysiological abnormalities were inconsistent in GERD. T1DM patients averaged 46.2% (P ¼ 0.0003) less preprandial and similar (P ¼ 0.32) postprandial time in normogastria compared with controls, and had a lower power ratio (SMD À2.20, 95% confidence interval [CI]: À4.25 to À0.15; P ¼ 0.036). Symptom correlations with gastric electrophysiology were inconsistently reported. Abnormalities in gastric electrophysiology were identifiable across a range of pediatric patients with gastroduodenal symptoms on meta-analysis. However, techniques have been inconsistent, and standardized and more reliable EGG methods are desirable to further define these findings and their potential utility in clinical practice.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Electrogastrography Abnormalities in Pediatric Gastroduodenal Disorders

Bhat

Varghese²,

Carson³

et al. 2021

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

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“…The authors proposed that the sympathetic peak reflects adaption to the temperature change and this could be slower in children, but the delayed sympathetic peak in our study could also be due to stronger stimulation. Thus, in order to capture potential effects of n-3 LCPUFA on the sympathetic and parasympathetic balance, it is essential to analyse heart rhythm recordings after stress in short-time intervals rather than 5-20 min intervals as used in previous studies (13,31,32) .…”

Section: Discussionmentioning

confidence: 99%

Exploring the effects of oily fish consumption on measures of acute and long-term stress in healthy 8–9-year-old children: the FiSK Junior randomised trial

et al. 2020

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Long-chain n-3 PUFA (n-3 LCPUFA) are known to reduce blood pressure (BP), heart rate and vagal tone, but potential stress-mitigating effects of n-3 LCPUFA are not well investigated. We explored the effects of oily fish consumption on long-term stress and the stress response in schoolchildren. Healthy 8–9-year-old children were randomised to receive about 300 g/week of oily fish or poultry for 12 weeks (199 randomised, 197 completing). At baseline and endpoint, we measured erythrocyte n-3 LCPUFA, hair cortisol and the response to a 1-min cold pressor test (CPT) on saliva cortisol, BP and continuous electrocardiogram recordings. Post-intervention hair cortisol did not differ between the groups, but sex-specificity was indicated (Psex × group = 0·074, boys: −0·9 (95 % CI −2·9, 1·0) ng/g, girls: 0·7 (95 % CI −0·2, 1·6) ng/g). Children in the fish group tended to be less prone to terminate CPT prematurely (OR 0·20 (95 % CI 0·02, 1·04)). Mean heart beat interval during CPT was 18·2 (95 % CI 0·3, 36·6) ms longer and high frequency power increased (159 (95 % CI 29, 289) ms2) in the fish v. poultry group. The cardiac autonomic response in the 10 min following CPT was characterised by a sympathetic peak followed by a parasympathetic peak, which was most pronounced in the fish group. This exploratory study does not support a strong effect of oily fish consumption on stress but indicates that oily fish consumption may increase vagal cardiac tone during the physiological response to CPT. These results warrant further investigation.

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“…This impaired accommodation may be linked to abnormalities of the vagal reflex and intrinsic inhibitory innervation. 115 Studies on adults and children highlighted abnormal gastric sensorimotor function. 116 The visceral hypersensitivity to gastric distention in FD can be considered as a model of a gut-brain axis disorder.…”

Section: Functional Dyspepsiamentioning

confidence: 99%

Brain to Belly: Abdominal Variants of Migraine and Functional Abdominal Pain Disorders Associated With Migraine

Lenglart

Caula

Moulding

et al. 2021

J Neurogastroenterol Motil

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Migraine is one of the most frequent causes of primary headache and 9% of children suffer from migraines. Most children will continue to experience migraine attacks as adults, therefore it is imperative that we have a thorough understanding of this major health issue. This article considers the so-called abdominal variants of migraine, which are more commonly seen in children rather than adults: abdominal migraine, cyclic vomiting syndrome, and infantile colic. Other functional abdominal pain disorders such as irritable bowel syndrome and functional dyspepsia have also been linked to migraine in clinical studies. The common pathophysiological root of these diseases seems to be the gut-brain axis mechanism. Abdominal variants of migraine are considered pediatric precursors of migraine whereas the functional abdominal pain disorders related to migraine seem to share a pathophysiological root with no temporarily link as for today. In this review we aim to describe the epidemiological background, the current pathophysiological theories and the relationship of each disease to migraine. This review is the first to compile abdominal variants of migraine and functional abdominal pain disorders associated with migraine and we endeavor to elucidate the broad spectrum of migraine-related episodes in children.

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Heart Rate Variability and Gastric Electrical Response to a Cold Pressor Task in Youth with Functional Dyspepsia

Cited by 4 publications

References 37 publications

Electrogastrography Abnormalities in Pediatric Gastroduodenal Disorders

Electrogastrography Abnormalities in Pediatric Gastroduodenal Disorders

Exploring the effects of oily fish consumption on measures of acute and long-term stress in healthy 8–9-year-old children: the FiSK Junior randomised trial

Brain to Belly: Abdominal Variants of Migraine and Functional Abdominal Pain Disorders Associated With Migraine

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