Heart Rate Variability after Treatment for Depression in North Korean Defectors

Lee, Moon Soo; Seo, Yae Eun; Mok, Young Eun; Lee, So Hee

doi:10.1007/s10484-020-09491-y

Cited by 4 publications

(5 citation statements)

References 32 publications

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“…Some recent studies have focused on different clinical subdimensions of MDD. Lee et al [ 48 ] showed a positive correlation between fatigue-related items of the Hamilton Depression Rating Scale (HDRS) and LF-HRV. The latter was positively correlated with the items “midnight insomnia” and “slower thinking.” In the same line, Adolph et al [ 43 ] found that HF-HRV in reaction to watching a sad film was predictive of higher scores on suicidal ideation, whereas HF-HRV at rest was not predictive of suicidal ideation.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Digital Phenotyping for Differential Diagnosis of Major Depressive Episode: Narrative Review

Ettore¹,

Müller²,

Hinze³

et al. 2023

JMIR Ment Health

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Background Major depressive episode (MDE) is a common clinical syndrome. It can be found in different pathologies such as major depressive disorder (MDD), bipolar disorder (BD), posttraumatic stress disorder (PTSD), or even occur in the context of psychological trauma. However, only 1 syndrome is described in international classifications (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition [DSM-5]/International Classification of Diseases 11th Revision [ICD-11]), which do not take into account the underlying pathology at the origin of the MDE. Clinical interviews are currently the best source of information to obtain the etiological diagnosis of MDE. Nevertheless, it does not allow an early diagnosis and there are no objective measures of extracted clinical information. To remedy this, the use of digital tools and their correlation with clinical symptomatology could be useful. Objective We aimed to review the current application of digital tools for MDE diagnosis while highlighting shortcomings for further research. In addition, our work was focused on digital devices easy to use during clinical interview and mental health issues where depression is common. Methods We conducted a narrative review of the use of digital tools during clinical interviews for MDE by searching papers published in PubMed/MEDLINE, Web of Science, and Google Scholar databases since February 2010. The search was conducted from June to September 2021. Potentially relevant papers were then compared against a checklist for relevance and reviewed independently for inclusion, with focus on 4 allocated topics of (1) automated voice analysis, behavior analysis by (2) video and physiological measures, (3) heart rate variability (HRV), and (4) electrodermal activity (EDA). For this purpose, we were interested in 4 frequently found clinical conditions in which MDE can occur: (1) MDD, (2) BD, (3) PTSD, and (4) psychological trauma. Results A total of 74 relevant papers on the subject were qualitatively analyzed and the information was synthesized. Thus, a digital phenotype of MDE seems to emerge consisting of modifications in speech features (namely, temporal, prosodic, spectral, source, and formants) and in speech content, modifications in nonverbal behavior (head, hand, body and eyes movement, facial expressivity, and gaze), and a decrease in physiological measurements (HRV and EDA). We not only found similarities but also differences when MDE occurs in MDD, BD, PTSD, or psychological trauma. However, comparative studies were rare in BD or PTSD conditions, which does not allow us to identify clear and distinct digital phenotypes. Conclusions Our search identified markers from several modalities that hold promise for helping with a more objective diagnosis of MDE. To validate their potential, further longitudinal and prospective studies are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Heart Rate Variabilitymentioning

confidence: 99%

Digital Phenotyping for Differential Diagnosis of Major Depressive Episode: Narrative Review

Ettore¹,

Müller²,

Hinze³

et al. 2023

JMIR Ment Health

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“…For example, the associations between some symptoms of MDD measured by HDS and HRV have already been reported. In this sense, melancholic features of MDD were related to HRV parameters using frequency methods 28 and temporal parameters (SDNN and RMSSD) 29 . The existent evidence shows a relationship between HRV and the severity of depression; for example, patients with more severe depression tend to have a lower HRV than those with less severe depression 29,30 .…”

Section: Discussion Conclusion and Limitationsmentioning

confidence: 99%

“…In this sense, melancholic features of MDD were related to HRV parameters using frequency methods 28 and temporal parameters (SDNN and RMSSD) 29 . The existent evidence shows a relationship between HRV and the severity of depression; for example, patients with more severe depression tend to have a lower HRV than those with less severe depression 29,30 . Some limitations should be noted, especially the sample sizes; had they been larger, we could have formed subgroups based on cigarette consumption.…”

Section: Discussion Conclusion and Limitationsmentioning

confidence: 99%

Clinical and psychophysiological features of smoking and depression (preliminary results)

Cañizares-Gómez,

Reyes-López,

Carbajal-Valenzuela

et al. 2024

RMN

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“…26 The range of CPTSD prevalence was 11.3% 27 to 40.7%, 9 while another study reported a lifetime prevalence of 15.3%. 11 Twenty-four studies were conducted with participants living in the community, 9,11,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][46][47][48]61,62 8 studies at Hanawon (The Settlement Support Center for North Korean defectors), 26,27,[50][51][52][53][54][55] 6 studies at medical centers, 25,45,48,[56][57][58][59] and 2 studies were conducted using an online survey. 49,60 Out of 40 studies reviewed, only one study reported the longitudinal trajectories of the mental health of North Korean defectors.…”

Section: General Characteristics Of the Included Proms And Studiesmentioning

confidence: 99%

Properties of Patient-Reported Outcome Measures for Post-Traumatic Stress Disorder in North Korean Defectors: A Scoping Review

Kim¹,

Kim²,

Chu³

2023

Psychiatry Investig

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Objective Posttraumatic stress disorder (PTSD) is highly prevalent among North Korean defectors. This scoping review aimed to appraise the measurement properties of patient-reported outcome measures (PROMs) that assess PTSD among North Korean defectors.Methods A systematic search was conducted using Research Information Sharing Service, ScienceON, PubMed, and Embase from their inception up to September 15, 2022. Each measurement properties of the included PROMs were evaluated using COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN) methodology. First, the methodological quality of each study on measurement properties was evaluated using the COSMIN Risk of Bias checklist. Second, the result of each single study on a measurement property was rated against the updated criteria for good measurement properties.Results After screening the articles, nine instruments from 40 studies were included. Among these instruments, Impact of Event ScaleRevised was the most frequently used (13 studies [38.1%]), followed by the Trauma Scale for North Korean Refugees, PTSD Checklist, and Posttraumatic Diagnostic Scale. The theoretical basis of all PROMs was secure in terms of content validity. The most frequently tested characteristics in measurement properties for internal structure were internal consistency, criterion validity, and convergent validity. No study reported sufficient structural validity as confirmatory factor analysis results with a model fit.Conclusion There is insufficient evidence to support the recommendation of a specific PROM for use among North Korean defectors with PTSD.

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Heart Rate Variability after Treatment for Depression in North Korean Defectors

Cited by 4 publications

References 32 publications

Digital Phenotyping for Differential Diagnosis of Major Depressive Episode: Narrative Review

Digital Phenotyping for Differential Diagnosis of Major Depressive Episode: Narrative Review

Clinical and psychophysiological features of smoking and depression (preliminary results)

Properties of Patient-Reported Outcome Measures for Post-Traumatic Stress Disorder in North Korean Defectors: A Scoping Review

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