Heart rate, serotonin transporter linked polymorphic region (5-HTTLPR) genotype, and violence in an incarcerated sample

Armstrong, Todd A.; Boisvert, Danielle; Flores, Shahida; Symonds, Mary; Gangitano, David

doi:10.1016/j.jcrimjus.2017.05.012

Cited by 6 publications

(4 citation statements)

References 81 publications

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“…Based on a systematic review, the association between serotonin and aggression is rather mixed, where reduced 5-hydroxytryptamine (5-HT) concentration in central nervous system (CNS) was associated with reactive aggression (impulsivity; response to provocation), whereas increased 5-HT (small number of findings) may be related to callousunemotional traits, which is another possible pathway to aggressive behavior (Runions et al, 2019). In line with this, SLC6A4 * HTTLPR or 5-HTTLPR (serotonin transporter) was associated with aggression within the population of Pakistan (Qadeer et al, 2021), China (Zhang et al, 2017), and the United States of America (Armstrong et al, 2017), whereas, in a study conducted among Russian inmates, such correlation was not found (Toshchakova et al, 2017). Furthermore, other genes of serotonin such as 5-hydroxytryptamine receptor 2A (5HTR2A), 5-hydroxytryptamine receptor 2B (5HTR2B), and 5-hydroxytryptamine receptor 2C (5HTR2C) also showed no association with aggressive behavior (Toshchakova et al, 2017;Qadeer et al, 2021), suggesting a stronger link between brain serotonin level and aggression rather than the receptors, which was also proven by studies using selective serotonin reuptake inhibitors (SSRIs) (Nord et al, 2013;Lagerberg et al, 2020).…”

Section: Serotonin In Aud and Aggressionmentioning

confidence: 95%

“…Aggression is a complex behavior involving interactions between the gene, environment, personality, and physiology (Armstrong et al, 2017 ; Zhang et al, 2017 ; Kanen et al, 2021 ). Dysregulation of serotonin is associated with many psychiatric disorders (Rappek et al, 2018 ; Conio et al, 2020 ; Fanning et al, 2020 ) due to the widespread distribution of serotonergic fibers originating from midbrain raphe nuclei to various other regions (Sharp and Barnes, 2020 ).…”

Section: Serotonin In Aud and Aggressionmentioning

confidence: 99%

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Alcohol, Aggression, and Violence: From Public Health to Neuroscience

et al. 2021

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Alcohol has been associated with violent crimes and domestic violence across many nations. Various etiological factors were linked to chronic alcohol use and violence including psychiatric comorbidities of perpetrators such as personality disorders, mood disorders, and intermittent explosive disorders. Aggression is the precursor of violence and individuals prone to aggressive behaviors are more likely to commit impulsive violent crimes, especially under the influence of alcohol. Findings from brain studies indicate long-term alcohol consumption induced morphological changes in brain regions involved in self-control, decision-making, and emotional processing. In line with this, the inherent dopaminergic and serotonergic anomalies seen in aggressive individuals increase their susceptibility to commit violent crimes when alcohol present in their system. In relation to this, this article intends to investigate the influence of alcohol on aggression with sociopsychological and neuroscientific perspectives by looking into comorbidity of personality or mood disorders, state of the mind during alcohol consumption, types of beverages, environmental trigger, neurochemical changes, and gender differences that influence individual responses to alcohol intake and susceptibility to intoxicated aggression.

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Section: Serotonin In Aud and Aggressionmentioning

confidence: 95%

Section: Serotonin In Aud and Aggressionmentioning

confidence: 99%

Alcohol, Aggression, and Violence: From Public Health to Neuroscience

et al. 2021

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“…References of Table1:Armstrong et al, 2009Armstrong et al, , 2017Arriaga et al, 2008;Assaad et al, 2003Assaad et al, , 2006Assaad, 2002;Babcock et al, 2004Babcock et al, , 2005Babcock and Michonski, 2019;Babcock and Potthoff, 2020;Potthoff, 2016;Babel et al, 2016;Bare et al, 2004;Beauchaine, 2002aBeauchaine, , 2002bBenning et al, 2005;Betensky and Contrada, 2010;Birbaumer et al, 2005;Bobadilla and Taylor, 2007;Bobadilla, 2008;Broom, 2012;Brown, 2015;Casey et al, 2013;Cauffman et al, 2005;da Silva et al, 2014;de Barros et al, 2013;De Vries-Bouw et al, 2011Popma et al, 2006;de Wied et al, 2012;Dindo and Fowles, 2011, 2008;Dindo, 2008;Fanti et al, 2017;Florez et al, 2017;Fung et al, 2005;Loeber et al, 2007;Galan et al, 2017;Gao et al, 2012;Gerra et al, 2003;Goulter et al, 2019;Hansen et al, 2007;Hasan et al, 2013;Hong et al, 2018;…”

mentioning

confidence: 99%

Heart rate and skin conductance associations with physical aggression, psychopathy, antisocial personality disorder and conduct disorder: An updated meta-analysis

Looff

Cornet

Kogel³

et al. 2022

Neuroscience & Biobehavioral Reviews

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“…L/L genotype of 5-HTTLPR was found to be associated with aggressive and violent behavior 72 , borderline personality disorders 73 and suicidal behavior 74 . Low heart rate and 5-HTTLPR L/L genotype were associated with higher arrest rates for violence in an incarcerated sample of American men 75 . Other psychopathologies in a violent population, such as depression, were also reported to be associated with both the L allele and L/L genotype of 5-HTTLPR polymorphism in Russian criminal offenders 21 .…”

Section: Discussionmentioning

confidence: 89%

Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin

Qadeer

Amar

Huang

et al. 2021

Sci Rep

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The serotonin transporter (SLC6A4), 5-HT2A (HTR2A) and 5-HT2B (HTR2B) recepter genes, express proteins that are important regulators of serotonin reuptake and signaling, and thereby may contribute to the pathogenesis of aggressive criminal behavior. 370 sentenced murderers in Pakistani prisons and 359 men without any history of violence or criminal delinquency were genotyped for six candidate polymorphisms in SLC6A4, HTR2A and HTR2B genes. An association of higher expressing L/L and LA/LA variants of the 5-HTTLPR polymorphism was observed with homicidal behavior (bi-allelic: OR = 1.29, p = 0.016, tri-allelic: OR = 1.32, p = 0.015) and in the murderer group only with response to verbal abuse (OR = 2.11, p = 0.015), but not with other measures of self-reported aggression. L/L and LA/LA genotypes of the 5-HTTLPR polymorphism were associated with higher aggression scores on STAX1 scale of aggression compared to lower expressing genotypes (S/S, S/LG, LG/LG) in prison inmates. No associations were apparent for other serotonergic gene polymorphisms analyzed. Using the Braineac and GTEx databases, we demonstrated significant eQTL based functional effects for rs25531 in HTTLPR and other serotonergic polymorphisms analyzed in different brain regions and peripheral tissues. In conclusion, these findings implicate SLC6A4* HTTLPR as a major genetic determinant associated with criminal aggression. Future studies are needed to replicate this finding and establish the biologic intermediate phenotypes mediating this relationship.

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Heart rate, serotonin transporter linked polymorphic region (5-HTTLPR) genotype, and violence in an incarcerated sample

Cited by 6 publications

References 81 publications

Alcohol, Aggression, and Violence: From Public Health to Neuroscience

Alcohol, Aggression, and Violence: From Public Health to Neuroscience

Heart rate and skin conductance associations with physical aggression, psychopathy, antisocial personality disorder and conduct disorder: An updated meta-analysis

Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin

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