Heart rate reduction with ivabradine increases ischaemia-induced ventricular fibrillation threshold: Role of myocyte structure and myocardial perfusion

Vaillant, Fanny; Dehina, Leila; Mazzadi, Alejandro; Descotes, Jacques; Chevalier, Philippe; Tabib, A.; Bui‐Xuan, Bernard; Riera, Cécile; Belhani, Dalila; Timour, Quadiri

doi:10.1016/j.resuscitation.2011.03.032

Cited by 19 publications

(13 citation statements)

References 30 publications

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“…Associations of heart rate with SCD may also be consistent with experimental data showing diminishing ventricular fibrillation thresholds as heart rate is increased in stimulation studies and increasing thresholds when heart rate is lowered with ivabradine (32).…”

Section: Associations Between Heart Rate and Contractility And Rhythmsupporting

confidence: 86%

Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study

Archangelidi

Pujades-Rodríguez

Jouven

et al. 2018

Eur J Prev Cardiolog

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Background In healthy population cohorts, resting heart rate above 90 bpm is associated with mortality from coronary heart disease, but it is not clear whether associations are present at lower heart rates or whether these associations differ between women. Methods The CALIBER resource of linked electronic health records from primary care, hospitalisations, myocardial infarction registry and cause-specific mortality in the UK was used to assess associations between resting heart rate and 12 fatal and non-fatal coronary, cardiac, cerebral and peripheral vascular cardiovascular diseases and death using Cox proportional hazard models. Results Among 233,970 patients, 29,690 fatal and non-fatal events occurred. Fully adjusted models showed that resting heart rate was not associated in men or women with cerebrovascular events. In men a resting heart rate of 70-79 bpm (29.1% of all men) versus less than 60 bpm was associated with an increased risk of heart failure (hazard ratio (HR) 1.65, 95% confidence interval (CI) 1.26-2.16), unheralded coronary death (HR 1.65, 95% CI 1.13-2.41), total cardiovascular events (HR 1.22, 95% CI 1.15-1.28) and all-cause mortality (HR 1.39, 95% CI 1.22-1.58). Women with a higher resting heart rate level of 80-89 bpm versus 60 bpm had a higher risk of total cardiovascular disease events (HR 1.17, 95% CI 1.07-1.24) and all-cause mortality (HR 1.21, 95% CI 1.07-1.35) compared to a resting heart rate less than 60 bpm. The risk was also present at higher heart rates (>90 bpm) for heart failure and sudden cardiac death. Conclusions A resting heart rate that clinicians currently consider as 'normal' in the general population is specifically associated with the incidence of certain major cardiovascular diseases and death, with the risk starting at lower resting heart rate levels in men compared to women. Further research is required to evaluate whether interventions to lower resting heart rate are warranted to prevent disease. The study is registered at: clinicaltrials.gov (ID: NCT01947361).

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Section: Associations Between Heart Rate and Contractility And Rhythmsupporting

confidence: 86%

Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study

Archangelidi

Pujades-Rodríguez

Jouven

et al. 2018

Eur J Prev Cardiolog

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“…Th e variation in associations may be due to the diff erences in alcohol consumption patterns between rural and urban areas and across diff erent countries and the type of alcohol consumed. For example, Australian rural and regional areas tend to have higher rates of alcohol use compared to urban areas (43,44), whereas in America, urban locales have higher alcohol consumption patterns (45).…”

Section: Discussionmentioning

confidence: 99%

Review of Screening Studies for Atrial Fibrillation in Rural Populations of 11 Countries

Gavino

McLachlan

2017

Baylor University Medical Center Proceedings

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Atrial fibrillation (AF) is a common cardiac arrhythmia, and pathological burden can be influenced by environmental factors. The rural environment may influence the burden of AF, although no systematic review studies have been conducted to address this issue. We performed a systematic review of AF screening studies conducted in rural global populations to determine the burden, risk factors, and screening methods surrounding AF in these settings. Out of the 1792 articles gathered from a keyword search of medical databases and reference lists, 18 publications from 11 countries were included in our analysis. The pooled prevalence of AF across the studies was 2.05% (95% confidence interval, 1.97%-2.13%) and ranged from 0.3% to 10.87%. Only one study utilized a handheld electrocardiogram to screen AF, while the rest used the 12-lead electrocardiogram. AF risk factors reported across studies varied and included increasing age, male gender, hypertension, diabetes, prior myocardial infarction or stroke, obesity, hyperlipidemia/hypercholesterolemia, alcohol consumption, and heart failure. However, none of the studies assessed all risk factors. We suggest that future research on AF in rural communities examine a complete checklist of AF risk factors to better understand their influence on AF burden and development. This will aid in understanding rural prevention strategies and the management of detected AF cases specific to rural areas. At present, the burden of AF in rural communities is poorly understood and has been underreported.

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“…Эти данные согласуются с исследованиями, в которых показано, что ивабрадин может защищать от острых аритмий, вызванных ишемией: предварительное введение препарата перед индукцией ишемии в сердцах животных повышало порог фибрилляции желудочков в 2,9 раза. При этом, в большей степени сохранялась ультраструктура кардиомиоцитов в зоне ишемии и был лучшим региональный миокардиальный кровоток во время реперфузии, оцениваемый с помощью позитронно-эмиссионной томографии [21,22]. Потенциальные антиаритмические механизмы ивабрадина в этом случае, с точки зрения авторов, включают подавление Ca ++ утечки из саркоплазматического ретикулума, ингибирование тока I f в HCN4 каналах, экспрессия которых увеличивается в желудочках во время острой ишемии, и уменьшение дисперсии реполяризации миокарда [22].…”

Section: Ivabradine Outside the Clinical Guidelines: Interest Of A Prunclassified

Ivabradine Outside the Clinical Guidelines: Interest of a Practitioner

Тарловская¹

2018

Russ J Cardiol

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Heart rate reduction with ivabradine increases ischaemia-induced ventricular fibrillation threshold: Role of myocyte structure and myocardial perfusion

Cited by 19 publications

References 30 publications

Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study

Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study

Review of Screening Studies for Atrial Fibrillation in Rural Populations of 11 Countries

Ivabradine Outside the Clinical Guidelines: Interest of a Practitioner

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