Heart Rate Reduction After Heart Transplantation With Beta-Blocker Versus the Selective If Channel Antagonist Ivabradine

Doesch, Andreas O.; Celik, Sultan; Ehlermann, Philipp; Frankenstein, Lutz; Zehelein, Joerg; Koch, Achim; Katus, Hugo A.; Dengler, Thomas J.

doi:10.1097/01.tp.0000285265.86954.80

Cited by 47 publications

(63 citation statements)

References 21 publications

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“…A previous study [19] showed that ivabradine, like betablockers, was effective to reduce HR in transplant patients. However, its impact on mortality was not assessed.…”

Section: Discussionmentioning

confidence: 99%

Impact of basal heart rate on long-term prognosis of heart transplant patients

et al. 2013

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“…A previous study [19] showed that ivabradine, like betablockers, was effective to reduce HR in transplant patients. However, its impact on mortality was not assessed.…”

Section: Discussionmentioning

confidence: 99%

Impact of basal heart rate on long-term prognosis of heart transplant patients

et al. 2013

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“…Lowering heart rate is therefore one of the most important therapeutic approaches in the treatment of these diseases. Currently used bradycardic drugs including ␤-adrenoceptor antagonists, and some Ca 2ϩ channel antagonists efficiently reduce heart rate, but their use is also limited by adverse reactions or contraindications (44,127). Given the key role of I h /HCN channels in cardiac pacemaking, these channels are very promising pharmacological targets for the development of novel and more specific heart-rate reducing agents (44).…”

Section: A Heart Rate-reducing Agentsmentioning

confidence: 99%

Hyperpolarization-Activated Cation Channels: From Genes to Function

Biel

Wahl‐Schott²,

Michalakis³

et al. 2009

Physiological Reviews

869

974

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Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises four members (HCN1-4) that are expressed in heart and nervous system. The current produced by HCN channels has been known as Ih (or If or Iq). Ih has also been designated as pacemaker current, because it plays a key role in controlling rhythmic activity of cardiac pacemaker cells and spontaneously firing neurons. Extensive studies over the last decade have provided convincing evidence that Ih is also involved in a number of basic physiological processes that are not directly associated with rhythmicity. Examples for these non-pacemaking functions of Ih are the determination of the resting membrane potential, dendritic integration, synaptic transmission, and learning. In this review we summarize recent insights into the structure, function, and cellular regulation of HCN channels. We also discuss in detail the different aspects of HCN channel physiology in the heart and nervous system. To this end, evidence on the role of individual HCN channel types arising from the analysis of HCN knockout mouse models is discussed. Finally, we provide an overview of the impact of HCN channels on the pathogenesis of several diseases and discuss recent attempts to establish HCN channels as drug targets.

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“…Moreover, in heart transplant recipients, sinus tachycardia is rather common as a consequence of graft denervation [4]. Following partial recovery from cardiogenic shock and IABP removal, we aimed at carefully slowing down heart rate with esmolol to improve cardiac function [5].…”

Section: Discussionmentioning

confidence: 99%

Cardiogenic Shock due to Tachycardiomyopathy after Heart Transplantation: Successful Treatment with Ivabradine

et al. 2010

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Tachycardia-induced cardiomyopathy refers to an impairment in left-ventricular function due to chronic or prolonged tachycardia. We describe a heart transplant patient who developed cardiogenic shock due to tachycardia-induced cardiomyopathy. Low-output failure was further aggravated by administration of a short-acting β-blocker during invasive hemodynamic monitoring. In contrast, heart rate control by administration of increasing doses of ivabradine supported recovery from cardiogenic shock and led to an improvement in the patient’s clinical condition as well as left-ventricular function during follow-up.

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Heart Rate Reduction After Heart Transplantation With Beta-Blocker Versus the Selective If Channel Antagonist Ivabradine

Cited by 47 publications

References 21 publications

Impact of basal heart rate on long-term prognosis of heart transplant patients

Impact of basal heart rate on long-term prognosis of heart transplant patients

Hyperpolarization-Activated Cation Channels: From Genes to Function

Cardiogenic Shock due to Tachycardiomyopathy after Heart Transplantation: Successful Treatment with Ivabradine

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