Heart rate of the dog following autonomic denervation

Long, Da; Truex, Raymond C.; Friedmann, K. R.; Olsen, A. K.; Phillips, Steven J.

doi:10.1002/ar.1091300107

Cited by 13 publications

(4 citation statements)

References 16 publications

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“…Since our data showed that there were not only species differences but also clear developmental differences in terms of changes in MBHR as a function of age and characteristics of MEHR, the pattern of such modifications may be used as an important and rather sensitive psychophysiological measurement of individual differences. Although the underlying factors responsible for these types of developmental differences are not yet known, our present data generally agree with the previously reported evidence that the heart-rate patterns of neonatal and postneonatal animals are not the same (e.g., Adolph, 1965;Clark, 1927;Long et al, 1958).…”

Section: Discussionsupporting

confidence: 93%

Development changes in the basal and evoked heart rate in neonatal rats.

Ashida¹

1972

Journal of Comparative and Physiological Psychology

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Section: Discussionsupporting

confidence: 93%

Development changes in the basal and evoked heart rate in neonatal rats.

Ashida¹

1972

Journal of Comparative and Physiological Psychology

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“…The characteristic features of the denervated heart at rest are its constant frequency and the complete absence of the respiratory sinus rhythm typically observed in the conscious quiescent dog (16,17). Resting heart rates range from 90 to 140 beats/min, and there is no immediate response to somatic or emotional stimuli (18).…”

Section: Restmentioning

confidence: 99%

Myocardial Performance after Excision of the Extrinsic Cardiac Nerves in the Dog

Donald

1974

Circulation Research

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The performance of the heart in the intact subject is determined by the complex interplay of cardiac and extracardiac factors; the initial length of the myocardial fibers and the state of activity of the cardiac autonomic nerves are most important. The profound changes in cardiac behavior that attend excitation of the cardiac autonomic nerves have led to the concept of neurogenic dominance in the control of cardiac output, particularly in situations that strongly constrain the cardiovascular system. This concept is basic to an evaluation of the mechanisms by which the heart responds to changes in the peripheral circulation and has important implications in clinical cardiac transplantation. In this review, the behavior of the denervated heart in different stressful situations is considered; the presentation is limited to studies in which dogs have been chronically deprived of both sympathetic and parasympathetic nerves. The role of cardiac receptors and their afferent innervation has recently been reviewed and is not discussed in this paper (1, 2). TECHNIQUES OF CARDIAC DENERVATIONThe four major techniques of cardiac denervation currently used are described briefly, because the method of denervation will influence the results obtained.(1) According to the methods of Gasser and Meek (3) and of Ashkar and Hamilton (4), the stelllate ganglia and thoracic paravertebral sympathetic chains are bilaterally excised from T-l to T-4. The right vagus nerve is sectioned distal to the right recurrent laryngeal nerve. During a second operation, the left vagus nerve is sectioned in the neck. Some cardiac sympathetic fibers remain biable but decentralized, and the myocardial content of catecholamines is reduced to a varying degree. Supersensitivity to catecholamines does not devel-From the Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901. Circulation Research. VoL XXXIV, April 1974op. The lungs and viscera are vagally denervated, resulting in altered respiratory dynamics, gastrointestinal disturbances, and loss in body weight. Vagal cardiopulmonary afferent nerves are interrupted.(2) Complete cardiac denervation is assured after orthotopic autografts or allografts. This techniquerequires cardiac bypass and results in significant morbidity and mortality. Sympathetic denervation is postganglionic, and the heart is depleted of and becomes supersensitive to catecholamines. Pulmonary afferent fibers are preserved, but afferent fibers that course along the aorta, the main pulmonary artery, or the superior vena cava are interrupted. Dependong on the technique used, afferent fibers from receptors in the pulmonary veins, posterior atrial wall, and ostia of the vena cava may (5) or may not (6) be preserved. After transplantation, variability in the functional integrity of the donor sinus node has been noted.(3) The technique of regional neural ablation (7) involves stripping the aorta, the main, right, and left pulmonary arteries, the pulmonary veins, the atria, and the vena cava. The per...

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“…Long, Truex, Friedmann, Olsen, and Phillips (1959) Long, Truex, Friedmann, Olsen, and Phillips (1958) and Jellinek, Kaye, Kaiser, and Cooper (1966). Markowitz, Archibald, and Downie (1964) recommended cauterizing the vocal cords or transecting the vagi, but sparing the right, recurrent laryngeal nerve.…”

Section: Cardiac Denervationmentioning

confidence: 99%

Canine cardiac denervation: a structural, functional, and chemical study

McKibben

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Heart rate of the dog following autonomic denervation

Cited by 13 publications

References 16 publications

Development changes in the basal and evoked heart rate in neonatal rats.

Development changes in the basal and evoked heart rate in neonatal rats.

Myocardial Performance after Excision of the Extrinsic Cardiac Nerves in the Dog

Canine cardiac denervation: a structural, functional, and chemical study

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