Heart rate–corrected QT interval duration is significantly associated with blood pressure in Chinese hypertensives

Peng, Shaojie; Yu, Yunxian; Hao, Ke; Huang, Xing; Li, Dong; Chen, Changzhong; Huang, Aiqun; Hong, Xiumei; Feng, Yan; Zhang, Yan; Li, Jianping; Zhang, Yuanyuan; Wu, Di; Wang, Xiaobin; Xu, Xiping

doi:10.1016/j.jelectrocard.2005.08.007

Cited by 28 publications

(17 citation statements)

References 15 publications

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“…[29–30] The pattern of QT parameters in this study population was similar to what was found among the Caucasians and similar studies reported among Nigerian subjects. [212231] The fact that about half of newly diagnosed hypertensive subjects had prolonged QT intervals which is a noninvasive stratification tool highlight the enormous role of early implementation of total cardiovascular care including adequate stratification and management for newly diagnosed hypertensive subjects.…”

Section: Discussionmentioning

confidence: 99%

QT Interval prolongation and dispersion: Epidemiology and clinical correlates in subjects with newly diagnosed systemic hypertension in Nigeria

Akintunde

Oyedeji

Familoni

et al. 2012

Journal of Cardiovascular Disease Research

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Background:The use of easily obtainable clinical and laboratory parameters to identify hypertensive patients with increased cardiovascular risk in resource limited settings cannot be overemphasized. Prolongation of QT intervals and increased dispersion has been associated with increased risk of cardiovascular death. The study aimed at describing the epidemiology of QT interval abnormalities among newly diagnosed hypertensive subjects and associated clinical correlates.Materials and Methods:One hundred and forty newly diagnosed hypertensive subjects and 70 controls were used for this study. Clinical and sociodemographic characteristics were obtained. Twelve lead resting electrocardiography, QT dispersion, heart rate corrected minimum and maximum QT intervals were determined manually. Increased QTcmax was defined at QTcmax >440msec. QT parameters were compared between various groups. SPSS 16.0 was used for data analysis.Results:The hypertensive subjects were well matched in age and gender distribution with controls. QTmax and QTcmax were significantly higher among hypertensive subjects than controls (379.7±45.1 vs. 356.7±35.6, 447.5± 49.0 vs. 414.5 ±34.7 ms, respectively, P<0.05). QTd and QTcd were also significantly higher among hypertensive subjects than controls (62.64±25.65 vs. 46.1±17.2, 73.8 ±30.0 vs. 52.5±18.8, respectively, P<0.05). Seventy three (52.14%) of the hypertensive subjects had QTcmax >440ms compared to 21.43% of controls, P=0.01. Increased QTc dispersion was present in 36.4% of hypertensive subjects. Hypertensive subjects with QT abnormalities had significantly higher mean waist hip ratio, mean body mass index and a higher proportion of smoking than controls.Conclusion:QT prolongation and increased QTc dispersion are common among newly diagnosed hypertensive Nigerians and seem to be significantly associated with obesity. Effective antihypertensive therapy and control of obesity are important management modality for newly diagnosed hypertensive patients.

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Section: Discussionmentioning

confidence: 99%

QT Interval prolongation and dispersion: Epidemiology and clinical correlates in subjects with newly diagnosed systemic hypertension in Nigeria

Akintunde

Oyedeji

Familoni

et al. 2012

Journal of Cardiovascular Disease Research

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“…Currently, several studies show a link between QT duration and blood pressure. The positive association of QT with blood pressure is found in the elderly and in hypertension (6,7). Additionally, an even stronger correlation is reported between QTc and systolic and diastolic blood pressure values than between QTc and LVM in hypertensive patients (8).…”

Section: Introductionmentioning

confidence: 92%

Prolonged QT Interval Is Associated with Blood Pressure Rather Than Left Ventricular Mass in Spontaneously Hypertensive Rats

Klimas

Stankovičová

Kyselovič

et al. 2008

Clinical and Experimental Hypertension

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QT interval is prolonged in hypertensive individuals, although the factors responsible for this increase are not completely understood. We questioned whether enhanced left ventricular mass (LVM) or increased systemic blood pressure represents the principal factor determining QT prolongation in the period of development of hypertension and left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHR). In 12-and 20-week-old SHR (SHR12 and SHR20) and age-matched normotensive Wistar-Kyoto rats (WKY12 and WKY20), arterial systolic blood pressure (sBP) was measured using tail-cuff technique. Orthogonal Frank ECG was registered in anaesthetized animals in vivo, and bipolar ECG was measured in spontaneously beating isolated hearts in vitro. Progressive increase of sBP and LVM resulted in significant QT prolongation in SHR20 as compared to WKY12, WKY20, and also to SHR12 in vivo (WKY12: 82 +/- 9 ms, WKY20: 81 +/- 9 ms, SHR12: 88 +/- 15 and SHR20: 100 +/- 10, respectively; p < 0.05) but not in isolated hearts (WKY20: 196 +/- 39 ms and SHR20: 220 +/- 55, respectively; NS). In whole animals, QT duration was positively related to sBP (r = 0.6842; p < 0.001) but not to LVM (r = 0.1632, NS) in SHR20. The results suggest that QT prolongation in SHR developing hypertension and LVH depends on blood pressure rather than increase in LVM. In this period, myocardial hypertrophy is probably the predisposition for QT prolongation, but the significant change manifests only in the presence of elevated systemic factors.

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“…The autonomic neuropathy partly contribute to induce QT prolongation [194], a parameter controlled by sexual hormones [195][196][197], which is the result of the total duration of ventricular myocardial depolarization and repolarization. When it is corrected for heart rate (QTc), it is predictive of cardiovascular mortality in apparently healthy people [198] of both sexes [199] as well as in DM [200].…”

Section: Diabetic Neuropathymentioning

confidence: 99%

Sex-Gender Differences in Diabetes Vascular Complications and Treatment

Franconi

Campesi

Occhioni³

et al. 2012

EMIDDT

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Diabetes mellitus and cardiovascular diseases act as two sides of the same coin: diabetes is an important risk factor for cardiovascular disease while patients with ischemic cardiovascular diseases often have diabetes or pre-diabetes. As firstly shown by Framingham study, diabetic women have an increased cardiovascular risk about 3.5 fold higher than non diabetic women, against an increase of "only" 2.1 fold found in male subjects. In view of the impact of sexual hormones on glucose homeostasis, the molecular pathways involved in insulin resistance suggest a sex-gender specificity mechanism in the development of diabetic complications leading to the unmet need of sex-gender therapeutic approaches. This has also been seen in other diabetic complications such as renal diseases, which seems to progress at a faster rate in females compared with males and women benefit less from treatment than do men. Of note, none of the trials done so far are primarily designed to assess sex-gender differences in the benefit from a specific intervention strategy, de facto excluding fertile women from experimentation. In order to provide a more evidence based medicine for women and to reach equity between men and women, sex-gender epidemiological reports, preclinical and clinical research are mandatory to evaluate the impact of gender on the outcomes and to improve sex-gender awareness and competency in the health care system. Future studies should consider sex-gender differences in the setting of randomized controlled trials with drugs.

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Heart rate–corrected QT interval duration is significantly associated with blood pressure in Chinese hypertensives

Cited by 28 publications

References 15 publications

QT Interval prolongation and dispersion: Epidemiology and clinical correlates in subjects with newly diagnosed systemic hypertension in Nigeria

QT Interval prolongation and dispersion: Epidemiology and clinical correlates in subjects with newly diagnosed systemic hypertension in Nigeria

Prolonged QT Interval Is Associated with Blood Pressure Rather Than Left Ventricular Mass in Spontaneously Hypertensive Rats

Sex-Gender Differences in Diabetes Vascular Complications and Treatment

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