Heart Peptide Hormones: Adjunct and Primary Treatments of Cancer

Vesely, David L.

doi:10.21873/anticanres.11152

Cited by 13 publications

(14 citation statements)

References 52 publications

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“…Atrial natriuretic peptide (ANP) has been shown to inhibit tumor growth in vitro and in vivo studies [ 27 , 28 ]. ANP belongs to a family of cardiac and vascular-derived peptide hormones that plays a crucial role in cardiovascular homeostasis through blood pressure and volume regulation [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Association of atrial fibrillation and cancer: Analysis from two large population-based case-control studies

et al. 2018

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BackgroundAn association between atrial fibrillation (AF) and risk of cancer has been suggested in several studies, including prospective cohort studies. However, the magnitude and the temporal nature of this association remain unclear.MethodsData from two large prospective population-based case-control studies, the Molecular Epidemiology of Colorectal Cancer (MECC, n = 8,383) and the Breast Cancer in Northern Israel Study (BCINIS, n = 11,608), were used to better understand the nature and temporality of a possible association between cancer diagnosis and AF events before and after cancer diagnosis. A case-control study approach was employed to study prior AF as a risk factor for cancer, and a cohort study approach was employed to study incident cancer as a risk factor for AF.ResultsAF was associated with a significant reduced odds of cancer as reflected in the case-control approach, with an adjusted OR = 0.77 (95% CI, 0.65–0.91), while cancer was not found to be significantly associated with elevated risk of AF in the cohort approach, with an adjusted HR = 1.10 (0.98–1.23). The immediate period (90 days) after an AF event was associated with a 1.85 times increased risk of cancer, and the immediate period after the diagnosis of cancer was associated with a 3.4 fold increased risk of AF. These findings probably reflect both the effect of acute transient conditions associated with new cancer diagnosis and detection bias. Similar results were identified with colorectal and breast cancer cases.ConclusionsAtrial fibrillation of longer than 90 days duration is associated with reduced odds of new cancer diagnosis. The results of this study suggest that an association observed in prior research may be due to instances related to cancer diagnosis and detection bias rather than a causal relationship. However, there may be bias in the sampling and residual confounding that distort the associations.

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Section: Discussionmentioning

confidence: 99%

Association of atrial fibrillation and cancer: Analysis from two large population-based case-control studies

et al. 2018

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“…To date, a thorough search in the literature resulted in 758 publications on the subject. Natriuretic peptides can inhibit the progression of pancreatic-, breast-, small cell lung-, and prostate cancer in vivo and in vitro [ 45 ] and have been proposed as primary treatments for cancers [ 46 , 47 , 48 ] since they cause the death of cancer cells without affecting healthy cells [ 29 , 49 , 50 , 51 ]. Mechanisms underlying the anti-cancer effects of natriuretic hormones are based on the inhibition of conversion of GDP-Ras to GTP-Ras, one of the main pathways in cancer formation, and on the cGMP-mediated inhibition of the Ras-MEK 1/2-ERK 1/2 kinase cascade.…”

Section: Natriuretic Peptides and Cancermentioning

confidence: 99%

“…Mechanisms underlying the anti-cancer effects of natriuretic hormones are based on the inhibition of conversion of GDP-Ras to GTP-Ras, one of the main pathways in cancer formation, and on the cGMP-mediated inhibition of the Ras-MEK 1/2-ERK 1/2 kinase cascade. Furthermore, the hormones inhibit the crosstalk between Ras-MEK 1/2-ERK 1/2 kinase cascade and the pathways of VEGF, β-catenin, JNK, WNT, and STAT3, leading to the inhibition of the proto-oncogenes c-FOS and c-JUN in the nucleus of cancer cells [ 48 , 49 ] ( Figure 3 ). Given that tumor progression and malignancy also require the preservation of extracellular acidosis, cancer cells overexpress on their membrane several pH regulators.…”

Section: Natriuretic Peptides and Cancermentioning

confidence: 99%

“…As for the therapeutic use of natriuretic peptides, Serafino and Pierimarchi [ 49 ] defined ANP as a magic bullet for cancer therapy because it can inhibit tumor growth both in vitro and in vivo [ 45 ]. Indeed, these hormones, injected subcutaneously for one month by osmotic pumps, are capable of inhibiting the growth of human cancers, thus making these peptides attractive candidates for fighting cancer [ 46 , 47 , 48 , 51 ]. The capability of targeting several pathways, pivotal for cell neoplastic transformation and solid tumor survival, supports the value of ANP for preventive and therapeutic strategies, also based on the fact that neither cytotoxicity nor a single side-effect is associated with subcutaneous infusion of these peptide hormones, which, by pharmacokinetic analysis, is the optimal method of administration [ 48 , 49 , 112 ].…”

Section: Natriuretic Peptides and Prostate Cancermentioning

confidence: 99%

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Natriuretic Peptides: The Case of Prostate Cancer

et al. 2017

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Cardiac natriuretic peptides have long been known to act as main players in the homeostatic control of blood pressure, salt and water balance. However, in the last few decades, new properties have been ascribed to these hormones. A systematic review of English articles using MEDLINE Search terms included prostate cancer, inflammation, cardiac hormones, atrial natriuretic peptide, and brain natriuretic peptide. Most recent publications were selected. Natriuretic peptides are strongly connected to the immune system, whose two branches, innate and adaptive, are finely tuned and organized to kill invaders and repair injured tissues. These peptides control the immune response and act as anti-inflammatory and immune-modulatory agents. In addition, in cancers, natriuretic peptides have anti-proliferative effects by molecular mechanisms based on the inhibition/regulation of several pathways promoting cell proliferation and survival. Nowadays, it is accepted that chronic inflammation is a crucial player in prostate cancer development and progression. In this review, we summarize the current knowledge on the link between prostate cancer and inflammation and the potential use of natriuretic peptides as anti-inflammatory and anticancer agents.

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“…The peptide inhibits the growth of smooth myocytes, endothelial cells, and the activity of fibroblasts [9]. The peptide is involved in the differentiation of cardiac myocytes [10], reduces hypertrophy [11], has anti-inflammatory effect, and so on [12]. The definition of ANP concentration in the blood has diagnostic and prognostic value [13].…”

Section: Introductionmentioning

confidence: 99%

Morphology of Right Atrium Myocytes

Bugrova¹

2018

Muscle Cell and Tissue - Current Status of Research Field

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The chapter of this book is devoted to characteristics of the ultrastructure and function of secretory cardiac myocytes of the right atrium in norm and the experimental pathology in rats. The data were obtained at various models, such as clinical death, renovascular hypertension in rats, and in the isolated Langendorff-perfused rat hearts. We investigated the effect of the drug Mexidol on morphological and functional characteristics of endocrine cardiac myocytes in rats and in the isolated heart. Quantitative data on intracellular structures of atrial myocytes were presented. We estimated the accumulation of the atrial natriuretic peptide in granules and excretion into the sarcoplasm in secretory cardiac myocytes. The results were obtained using the methods of transmission electron microscopy and immunocytochemistry. The study makes an important contribution to histology and improves the understanding of the function of the heart as an endocrine organ. This chapter is intended for students of medical and biological universities and for experts.

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Heart Peptide Hormones: Adjunct and Primary Treatments of Cancer

Cited by 13 publications

References 52 publications

Association of atrial fibrillation and cancer: Analysis from two large population-based case-control studies

Association of atrial fibrillation and cancer: Analysis from two large population-based case-control studies

Natriuretic Peptides: The Case of Prostate Cancer

Morphology of Right Atrium Myocytes

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