Heart-on-a-chip systems: disease modeling and drug screening applications

Butler, Derrick; Reyes, Darwin R.

doi:10.1039/d3lc00829k

Lab Chip

2024

DOI: 10.1039/d3lc00829k

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Heart-on-a-chip systems: disease modeling and drug screening applications

Derrick Butler,

Darwin R. Reyes

Abstract: Heart-on-chip systems are one of the tools at the forefront in the race to develop alternative in vitro preclinical testing for disease modeling, drug toxicity and efficacy assessment. Further innovation and standardization will accelerate their use.

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Advances in induced pluripotent stem cell‐derived cardiac myocytes: technological breakthroughs, key discoveries and new applications

Clancy,

Santana

2024

The Journal of Physiology

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A transformation is underway in precision and patient‐specific medicine. Rapid progress has been enabled by multiple new technologies including induced pluripotent stem cell‐derived cardiac myocytes (iPSC‐CMs). Here, we delve into these advancements and their future promise, focusing on the efficiency of reprogramming techniques, the fidelity of differentiation into the cardiac lineage, the functional characterization of the resulting cardiac myocytes, and the many applications of in silico models to understand general and patient‐specific mechanisms controlling excitation–contraction coupling in health and disease. Furthermore, we explore the current and potential applications of iPSC‐CMs in both research and clinical settings, underscoring the far‐reaching implications of this rapidly evolving field. image

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Advances in induced pluripotent stem cell‐derived cardiac myocytes: technological breakthroughs, key discoveries and new applications

Clancy,

Santana

2024

The Journal of Physiology

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Perspectives on organ-on-a-chip technology for natural products evaluation

Wang,

Miao,

Zhao

et al. 2024

Food &Amp; Medicine Homology

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Heart-on-a-chip systems: disease modeling and drug screening applications

Abstract: Heart-on-chip systems are one of the tools at the forefront in the race to develop alternative in vitro preclinical testing for disease modeling, drug toxicity and efficacy assessment. Further innovation and standardization will accelerate their use.

Cited by 2 publications

References 433 publications

Advances in induced pluripotent stem cell‐derived cardiac myocytes: technological breakthroughs, key discoveries and new applications

Advances in induced pluripotent stem cell‐derived cardiac myocytes: technological breakthroughs, key discoveries and new applications

Perspectives on organ-on-a-chip technology for natural products evaluation

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