Background: Heart murmurs in children are a source of concern for doctors and parents alike until cardiac diseases are ruled out. While most heart murmurs are innocent, they can also be the first sign of previously asymptomatic structural heart disease. Diagnosis of murmur can be done by investigations like X ray, ECG and 2 D Echo. Aim and objective: To study the profile of heart murmurs in correlation with clinical examination and 2D Echo. Methodology: In the present study, total of 1900 primary school children between 5 to 10 years studying in different schools near Dr. D. Y. Patil hospital Pimpri, Pune and also healthy children coming to Dr.D.Y.Patil Hospital were auscultated for Heart murmur. Further follow up and diagnostic test were done in those children who had Heart murmur. Diagnostic tests like 2D Echo were performed for further diagnosis of heart condition. Analysis was done in SPSS version 20.0 and Open Epi version 2.3. Results and discussion: The prevalence of heart murmur in asymptomatic children between age group 5 to 10 years in pimpri chinchwad locality is 8.6%. Out of 164 children with murmur, 36(21.9%) children had some cardiac anomalies or defects while 128(78.1%) had no cardiac anomaly detected on 2D ECHO. The most common cardiac anomaly found was Bicuspid aortic valve (33.3%), followed by small PFO (19.4%), ASD + TR (11.1%), ASD (8.3%).