Heart involvement in AIDS: a prospective study during various stages of the disease

Castro, S. De; Migliau, G; Silvestri, Annalisa De; d’Amati, Giulia; Giannantoni, Paride; Cartoni, Domenico; Kol, Amir; Vullo, Vincenzo; Cirelli, A

doi:10.1093/oxfordjournals.eurheartj.a060085

Cited by 113 publications

(57 citation statements)

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“…Mitochondrial toxicity, recognized as a common side effect of NRTIs, is associated with the development of a number of tissue-specific toxicities, which may limit the long-term use of NRTIs in AIDS treatment (1,8,28). Early AZT research demonstrated skeletal and cardiac mitochondrial myopathies (4,8,9,19,23). Target tissues for toxicity may differ significantly among the NRTIs on the basis of specific tissue requirements for oxidative phosphorylation, cellular uptake, or phosphorylation state (28).…”

mentioning

confidence: 99%

Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide

Sutliff¹,

Dikalov

Weiss

et al. 2002

American Journal of Physiology-Heart and Circulatory Physiology

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(NRTIs) have been used successfully to reduce acquired immunodeficiency syndrome mortality. However, the use of these compounds is associated with numerous tissue toxicities, including cardiomyopathy. These studies address the effects of NRTIs on vascular function. Functional assays of contraction and relaxation were performed on isolated mouse aorta segments obtained from FVB/n mice exposed to zidovudine (AZT), stavudine, or water for 35 days. AZT and stavudine treatment impaired sensitivity to endothelium-dependent relaxation by acetylcholine. Dihydroethidium staining revealed that AZT treatment was associated with an increase in superoxide levels. Pretreatment of AZT-treated vessels with tiron (1 mM), a free radical scavenger, restored endotheliumdependent relaxation in mice. In cellular preparations, electron spin resonance measurements revealed elevated superoxide in cultured endothelial cells exposed to AZT; elevation was dependent on the length of exposure. These results indicate that NRTIs impair endothelium-dependent relaxation by increasing superoxide levels and suggest that NRTI therapy contributes to cardiovascular complications in acquired immunodeficiency syndrome.

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mentioning

confidence: 99%

Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide

Sutliff¹,

Dikalov

Weiss

et al. 2002

American Journal of Physiology-Heart and Circulatory Physiology

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“…4,43 Echocardiographic studies in HIV-infected children and adults show a high prevalence of cardiac changes even in the absence of clinical signs and symptoms. 3,8,10,16,20,[21][22] Nevertheless, in this series, no echocardiographic changes were found in clinically asymptomatic or mildly symptomatic children, and thus similar to the course of the seroreverted children. Echocardiographic manifestations were detected in children with moderate signs and symptoms and moderate immunosuppression, and predominated in the highly compromised clinical and immunological groups.…”

Section: Discussionmentioning

confidence: 88%

“…Childhood mortality due to cardiac complications ranges from 1% to 9%. 2,4,8,10,[12][13][14][15][16][17][18][19][20][21][22][23] The ever-increasing number of children born to HIVpositive mothers, coupled with the complex etiopathogenesis of heart involvement and the need for further understanding of the natural history of clinical cardiac manifestations during childhood, led us to study children exposed perinatally to HIV-1. This is an eightyear clinical, electrocardiographic, and echocardiographic follow-up study.…”

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confidence: 99%

Estudo cardiológico longitudinal em crianças expostas ao vírus da imunodeficiência humana tipo 1 por via perinatal

Diógenes

Succi

Machado

et al. 2005

Arq. Bras. Cardiol.

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“…The presence of pericardial effusion is described with a prevalence of 5 to 30% of HIV-infected patients, according to series [5] [6], but it is in more than 80% of asymptomatic cases. Our prevalence is certainly below reality, because a non-negligible share of asymptomatic pericarditis [7], as well as more precise diagnostic methods, would…”

Section: Discussionmentioning

confidence: 99%

Etiological and Evolutionary Profile of the Child’s Pericarditis in Tropical Environments

Azagoh-Kouadio¹,

Enoh²,

Atteby³

et al. 2017

OJPed

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Background: Liquid pericarditis is a frequent cause of hospitalization in developing countries. Objective: of this study was to describe the etiological and evolutionary aspects of fluid pericarditis in pediatric cardiology at ICA. Methods: This was a retrospective study of 42 cases of fluid pericarditis diagnosed among 202 children hospitalized over a five-year period (1 st January 2009 to 31 st December 2014). All patients with pericardial effusion were included in the study. Results: Prevalence was estimated at 20.8% of hospitalizations, sex ratio was 1.1 with a female predominance (52%) and the mean age at 9.2 years (11 days to 15 years). The etiologic varieties identified were: tuberculosis 22 cases, 52%, rheumatic pericarditis 6 cases or 14.3%, chronic parietal endocarditis 5 cases (11.9%), bacterial pericarditis with trivial germ 3 cases (7.1% 3 cases (7.1%), post-surgery syndrome 2 cases (4.8%), umbilical post-catheterization 1 case (2.4%). HIV serology was positive in 11.9% of cases. The progression was favorable in 55% of the cases with 10% of deaths. Conclusion: Fluid pericarditis in children is a severe condition that is clearly on the rise today, especially in immunocompromised patients. Optimal management of fluid pericarditis in children is the best guarantee to avoid short-term tamponade and in the medium term constriction.

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Heart involvement in AIDS: a prospective study during various stages of the disease

Cited by 113 publications

References 0 publications

Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide

Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide

Estudo cardiológico longitudinal em crianças expostas ao vírus da imunodeficiência humana tipo 1 por via perinatal

Etiological and Evolutionary Profile of the Child’s Pericarditis in Tropical Environments

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