Heart Failure Severity and Quality of Warfarin Anticoagulation Control (From the WARCEF Trial)

Abstract

Previous studies in patients with atrial fibrillation showed that a history of heart failure (HF) could negatively impact anticoagulation quality, as measured by the average time in therapeutic range (TTR). Whether additional markers of HF severity are associated with TTR has not been investigated thoroughly. We aimed to examine the potential role of HF severity in the quality of warfarin control in patients with HF with reduced ejection fraction. Data from the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction Trial were used to investigate the association between TTR and HF severity. Multivariable logistic regression models were used to examine the association of markers of HF severity, including New York Heart Association (NYHA) class, Minnesota Living with HF (MLWHF) score, and frequency of HF hospitalization, with TTR ≥70% (high TTR). We included 1,067 participants (high TTR, N = 413; low TTR, N = 654) in the analysis. In unadjusted analysis, patients with a high TTR were older and less likely to have had strokes or receive other antiplatelet agents. Those patients also had lower NYHA class, better MLWHF scores, greater 6-minute walk distance, and lower frequency of HF hospitalizations. Multivariable analysis showed that NYHA class III and/or IV (Odds ratio [OR] 0.68 [95% confidence intervals [CIs] 0.49 to 0.94]), each 10-point increase in MLWHF score (i.e., worse health-related quality of life) (OR 0.92 [0.86 to 0.99]), and higher number of HF hospitalization per year (OR0.45 [0.30 to 0.67]) were associated with decreased likelihood of having high TTR. In HF patients with systolic dysfunction, NYHA class III and/or IV, poor health-related quality of life, and a higher rate of HF hospitalization were independently associated with suboptimal quality of warfarin anticoagulation control. These results affirm the need to assess the new approaches, such as direct oral anticoagulants, to prevent thromboembolism in this patient population.

Clinical Impact of the Time in Therapeutic Range on Early Hospital Readmission in Patients with Acute Heart Failure Treated with Oral Anticoagulation in Internal Medicine

“…HF leads to a deterioration of the patient’s quality of life as well as an increased risk of complications and hospital admissions, despite improvements in management and pharmacotherapy [ 12 , 13 ]. Anticoagulation with anti-vitamin K drugs in these patients could worsen this situation by increasing the risk of hospitalization in those who have suboptimal anticoagulation control [ 14 ].…”

Anticoagulation in Patients with Heart Failure and Sinus Rhythm

“…In addition, the severity of HF could affect the TTR. Lee, et al 30) further explored the WARCEF study and found that the New York Heart Association and Minnesota Living with HF scores were closely related to the TTR, and an increased severity of HF was associated with a lower TTR. A Study Assessing the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction, or Stroke in Participants with Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure (COMMANDER-HF) trial: The COMMANDER-HF trial 31) was a double-blind, randomized trial published in 2018, and it was the first clinical trial to investigate the effect of non-vitamin K oral anticoagulants (NOACs) on the anticoagulation of patients with HF and sinus rhythm.…”

Clinical Impact of the Time in Therapeutic Range on Early Hospital Readmission in Patients with Acute Heart Failure Treated with Oral Anticoagulation in Internal Medicine

“…HF leads to a deterioration of the patient's quality of life as well as an increased risk of complications and hospital admissions, despite improvements in management and pharmacotherapy [12,13]. Anticoagulation with anti-vitamin K drugs in these patients could worsen this situation by increasing the risk of hospitalization in those who have suboptimal anticoagulation control [14].…”