Heart Failure in Patients With Cancer Treated With Anthracyclines—Revisiting the Foundation of Cardio-Oncology

Fradley, Michael G.

doi:10.1001/jamanetworkopen.2022.54677

Cited by 4 publications

(1 citation statement)

References 8 publications

(14 reference statements)

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“…One of the main adverse reactions caused by these standard treatments is myocardial cell damage [ 161 ]. Anthracyclines are commonly used chemotherapy drugs for breast cancer, with significant cardiotoxicity, including cardiac dysfunction and heart failure [ 162 ]. These adverse effects may contribute to the inability of breast cancer patients to use adequate drug doses during treatment, rendering breast cancer a higher recurrence risk [ 163 ].…”

Section: Mechanism Of Action Of Ginsenosides Altering Breast Cancer H...mentioning

confidence: 99%

Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer

Jiang,

Fang,

Zhang

et al. 2023

Chin Med

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In 2021, breast cancer accounted for a substantial proportion of cancer cases and represented the second leading cause of cancer deaths among women worldwide. Although tumor cells originate from normal cells in the human body, they possess distinct biological characteristics resulting from changes in gene structure and function of cancer cells in contrast with normal cells. These distinguishing features, known as hallmarks of cancer cells, differ from those of normal cells. The hallmarks primarily include high metabolic activity, mitochondrial dysfunction, and resistance to cell death. Current evidence suggests that the fundamental hallmarks of tumor cells affect the tissue structure, function, and metabolism of tumor cells and their internal and external environment. Therefore, these fundamental hallmarks of tumor cells enable tumor cells to proliferate, invade and avoid apoptosis. Modifying these hallmarks of tumor cells represents a new and potentially promising approach to tumor treatment. The key to breast cancer treatment lies in identifying the optimal therapeutic agent with minimal toxicity to normal cells, considering the specific types of tumor cells in patients. Some herbal medicines contain active ingredients which can precisely achieve this purpose. In this review, we introduce Ginsenoside's mechanism and research significance in achieving the therapeutic effect of breast cancer by changing the functional hallmarks of tumor cells, providing a new perspective for the potential application of Ginsenoside as a therapeutic drug for breast cancer.

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Section: Mechanism Of Action Of Ginsenosides Altering Breast Cancer H...mentioning

confidence: 99%

Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer

Jiang,

Fang,

Zhang

et al. 2023

Chin Med

View full text Add to dashboard Cite

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Mechanisms of myocardial toxicity of antitumor drugs and potential therapeutic strategies: A review of the literature

Jia,

Wu,

Yang

et al. 2024

Current Problems in Cardiology

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Genetic susceptibility to chronic diseases leads to heart failure among Europeans: the influence of leukocyte telomere length

Wong,

Blechter,

Liu

et al. 2024

Human Molecular Genetics

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Background Genetic susceptibility to various chronic diseases has been shown to influence heart failure (HF) risk. However, the underlying biological pathways, particularly the role of leukocyte telomere length (LTL), are largely unknown. We investigated the impact of genetic susceptibility to chronic diseases and various traits on HF risk, and whether LTL mediates or modifies the pathways. Methods We conducted prospective cohort analyses on 404 883 European participants from the UK Biobank, including 9989 incident HF cases. Multivariable Cox regression was used to estimate associations between HF risk and 24 polygenic risk scores (PRSs) for various diseases or traits previously generated using a Bayesian approach. We assessed multiplicative interactions between the PRSs and LTL previously measured in the UK Biobank using quantitative PCR. Causal mediation analyses were conducted to estimate the proportion of the total effect of PRSs acting indirectly through LTL, an integrative marker of biological aging. Results We identified 9 PRSs associated with HF risk, including those for various cardiovascular diseases or traits, rheumatoid arthritis (P = 1.3E-04), and asthma (P = 1.8E-08). Additionally, longer LTL was strongly associated with decreased HF risk (P-trend = 1.7E-08). Notably, LTL strengthened the asthma-HF relationship significantly (P-interaction = 2.8E-03). However, LTL mediated only 1.13% (P < 0.001) of the total effect of the asthma PRS on HF risk. Conclusions Our findings shed light onto the shared genetic susceptibility between HF risk, asthma, rheumatoid arthritis, and other traits. Longer LTL strengthened the genetic effect of asthma in the pathway to HF. These results support consideration of LTL and PRSs in HF risk prediction.

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Heart Failure in Patients With Cancer Treated With Anthracyclines—Revisiting the Foundation of Cardio-Oncology

Cited by 4 publications

References 8 publications

Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer

Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer

Mechanisms of myocardial toxicity of antitumor drugs and potential therapeutic strategies: A review of the literature

Genetic susceptibility to chronic diseases leads to heart failure among Europeans: the influence of leukocyte telomere length

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