Heart Failure Elevates Serum Levels of Cibenzoline in Arrhythmic Patients

Pharmacokinetic Study and Limited Sampling Strategy of Cyclosporine in Japanese Heart Transplant Recipients

“…18,19 It has been reported that heart function affects pharmacokinetic parameters for some drugs. 20,21 The patients in this study had severe heart failure prior to transplantation, thus in the early stages postheart transplantation patients may potentially have decreased total body clearance, but which subsequently increases with time. Further studies are needed to investigate this issue.…”

Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects

“…Although many physicians know that CZ can cause hypoglycemia by accelerating endogenous insulin secretion, the present cases suggest that the possibility of CZ-induced hypoglycemia is relatively high among elderly subjects, particularly those with renal dysfunction and/or a frail status. We should also be aware of the possibility that the concentration of CZ can be elevated in subjects with heart failure (6). In addition, since CZ in metabolized by cytochrome P450 (CYP), we should be careful of the interaction with other drugs in practical medicine in order to avoid inadvertently increasing the CZ concentration in patients.…”

Introduction to Therapeutic Drug Monitoring

“…Therefore, therapeutic drug monitoring is crucial in avoiding drug toxicity in these patients (90). Recently, Kotake et al (91) reported that heart failure elevates the serum level of the drug cibenzoline, which is used in the treatment of arrhythmia.…”