Heart failure and risk of venous thromboembolism: a systematic review and meta-analysis

Tang, Liang; Wu, Yingying; Lip, Gregory Y.H.; Yin, Ping; Hu, Yu

doi:10.1016/s2352-3026(15)00228-8

Cited by 60 publications

(48 citation statements)

References 109 publications

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“…8,9 Previous studies have reported that diabetes, hypertension, cerebral vascular disease (CVA), heart failure, cancers, pregnancy, lower leg fracture and major surgery are associated with risk of VTE. [10][11][12][13][14] Prophylactic anticoagulants for reducing the risk of VTE may be considered for acutely ill patients. 15 However, a discrepancy has been observed between the incidence rates of VTE reported in Taiwan and in Western countries.…”

Section: Chung and Linmentioning

confidence: 99%

“…Deep vein thrombosis (DVT) and pulmonary embolism (PE) constitute VTE, which remains a major contributor to 30‐day and 1‐year case fatality rates . Previous studies have reported that diabetes, hypertension, cerebral vascular disease (CVA), heart failure, cancers, pregnancy, lower leg fracture and major surgery are associated with risk of VTE . Prophylactic anticoagulants for reducing the risk of VTE may be considered for acutely ill patients .…”

Section: Introductionmentioning

confidence: 99%

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Association between venous thromboembolism and acute pancreatitis: An analysis from the nationwide inpatient sample

Chung

Lin

2019

Clinical Respiratory J

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Background and Aims Acute inflammation of the pancreas may trigger a systemic inflammatory response and initiate coagulation. Few studies have been conducted on the association between venous thromboembolism (VTE) and acute pancreatitis (AP). We investigated the incidence and risk of VTE in patients with AP. Methods We conducted a retrospective cohort analysis for the nationwide AP cohort. We identified 91 786 patients with AP and 183 557 controls who were frequency‐matched according to sex, age (5‐y interval), and index year from the National Health Insurance Research Database between 2000 and 2008. The patients and controls were followed until diagnosis of deep vein thrombosis (DVT) or pulmonary embolism (PE), death or the end of 2011. Results The nationwide cohort study showed that patients with AP exhibited a higher incidence of VTE (13.1 vs 5.65 per 10 000 person‐y) than did the controls. After covariates were controlled for, the patients with AP had a 1.88‐fold higher risk of VTE than did the controls (adjusted hazard ratios [aHR] = 1.88; 95% confidence intervals [CI] = 1.68‐2.10). The incidence rates of DVT and PE were higher in the patients with AP than in the controls, irrespective of sex, age or comorbidity. The patients with AP exhibited a 1.86‐fold higher aHR of DVT (95% CI = 1.63‐2.12) and a 1.92‐fold higher aHR of PE (95% CI = 1.59‐2.31) than did the controls. Conclusion Patients with AP exhibited a significantly higher risk of VTE than did the controls.

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Section: Chung and Linmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between venous thromboembolism and acute pancreatitis: An analysis from the nationwide inpatient sample

Chung

Lin

2019

Clinical Respiratory J

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“…The covalent states of fibrinogen are altered in patients with heart failure The dynamic nature of the fibrinogen disulfides suggested that they may be altered in patients with circulatory disease. Heart failure is a circulatory disease and common independent risk factor for venous thromboembolism 23 . Thromoboprophylaxis is usual for high-risk patients.…”

Section: Number Of Fibrinogen Covalent States Is a Function Of Conditmentioning

confidence: 99%

Protein function achieved through multiple covalent states

Butera

Hogg

2019

Preprint

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The structure of proteins is defined by two main types of covalent bonds; the peptide bonds that link the amino acid residues and disulfide bonds that link pairs of cysteine amino acids. Disulfide bonds are introduced during protein folding and their formation is assumed to be complete in the mature, functional protein. We tested this assumption by quantifying the redox state of disulfide bonds in human blood proteins in their native environment. Using a differential cysteine alkylation and mass spectrometry method, we measured the redox state of disulfide bonds in circulating fibrinogen and von Willebrand factor. There is an extraordinary disulfide lability in the proteins, with 27 bonds in the two proteins ranging from 3 to 50% reduced in healthy human donors. Modelling of the data indicates that the proteins exist in hundreds of different disulfide-bonded states in the circulation. Different covalent states of fibrinogen are associated with different binding activities and their distribution is changed by fluid shear forces and altered in patients with cardiovascular disease, indicating that the different states have different functions and are dynamic. These findings have implications for protein function generally and how proteins are targeted in experimental settings and for therapeutic purposes.

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“…Additionally, according to a meta-analysis, hospitalized patients with heart failure had an RR of 1.49 (1.16–1.92) for VTE in Asians [7]. …”

Section: Introductionmentioning

confidence: 99%

Reduced cardiac function and risk of venous thromboembolism in Asian countries

Zhu

Tang

2017

Thrombosis J

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Patients with reduced cardiac function are thought to have a higher risk of venous thromboembolism (VTE). Additionally, they are vulnerable to complications of pulmonary embolism (PE) as well as right heart failure (HF), which in return is supposed to increase the rate of mortality. Studies focusing on VTE in heart failure patients were rare in Asian countries before the 21st century. Nowadays, more and more data are becoming available in this field in Asia. It is already known that heart failure can increase the risk of VTE, but so far a consensus on this issue has not been reached for many years, not only in Asian countries but all over the world. This condition may be due to the detailed pathological advancement in Virchow’s triad and some other theories. In clinical practice, VTE, especially PE is difficult to diagnose in patients with heart failure because of overlapping symptoms (e.g. cough and chest pain) and the elevation of laboratory markers (e.g. probrain natriuretic peptide (NT-proBNP) and D-dimer in both heart failure and VTE patients). Management of VTE in heart failure patients is also controversial because heart failure patients always have complications, such as renal failure and hepatic failure, which increase the risk of bleeding. In this study, we analyzed data from China, Japan, Korea, Singapore and India mainly to get a better understanding of the research progress in VTE in patients with heart failure. The aim of this review is to discuss the risk, incidence, advancement of diagnosis, management and prevention of VTE in patients with heart failure in Asian countries.

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Heart failure and risk of venous thromboembolism: a systematic review and meta-analysis

Cited by 60 publications

References 109 publications

Association between venous thromboembolism and acute pancreatitis: An analysis from the nationwide inpatient sample

Association between venous thromboembolism and acute pancreatitis: An analysis from the nationwide inpatient sample

Protein function achieved through multiple covalent states

Reduced cardiac function and risk of venous thromboembolism in Asian countries

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