Heart failure and obesity

Safiullina, A. A.; Uskach, T. M.; Saipudinova, Karina M.; Tereshchenko, S. N.; Чазова, И Е

doi:10.26442/00403660.2022.09.201837

Cited by 4 publications

(2 citation statements)

References 70 publications

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“…An observational study found a higher rate of heart failure in obese patients, which is the same result as our univariate MR [4,[21][22][23]. However, a large body of research has shown that individuals with obesity have a better prognosis than lean individuals with the same level of heart failure disease, which is known as obesity paradox [24][25][26].…”

Section: Discussionsupporting

confidence: 81%

Impact of obesity on heart failure risk is mediated by hypertension: univariable and multivariable Mendelian randomization study

Zhang,

et al. 2023

Preprint

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Obesity is a risk factor for heart failure, and patients with obesity and heart failure have a better prognosis. We attempted to explain this paradox by exploring the role of hypertension in obesity and heart failure.We performed univariable and multivariable Mendelian randomization (MR) analyses to investigate causal effects of obesity and hypertension on heart failure. Analysis using the inverse-variance weighted (IVW) method showed that obesity Ⅱ (ORIVW = 1.10, 95% CI = 1.05–1.15, P = 2.86 × 10− 5) and obesity Ⅰ (ORIVW = 1.17, 95% CI = 1.11–1.24, P = 8.41 × 10− 8) had a positive effect on the occurrence of heart failure. The IVW method showed a causal effect of obesity Ⅰ (ORIVW = 1.02, 95% CI = 1.00–1.02, P = 2.807× 10− 25) and obesity Ⅱ (ORIVW = 1.01, 95% CI = 1.00–1.02, P = 7.14 × 10− 11) on hypertension. After adjusting for hypertension using multivariate IVW, obesity II was not causally associated with heart failure.Both obesity and hypertension are risk factors for heart failure, and the effect of obesity on heart failure is mediated by hypertension.

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Section: Discussionsupporting

confidence: 81%

Impact of obesity on heart failure risk is mediated by hypertension: univariable and multivariable Mendelian randomization study

Zhang,

et al. 2023

Preprint

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“…Обращает на себя внимание, что среди пациентов с неблагоприятным течением СНсФВ отмечалась тенденция к более частому наличию ожирения (p=0,08), что соответствует концепции сердечнососудистого континуума и метаболического синдрома в условиях инсулинорезистентности [24,25] гностического и прогностического потенциала при различных нозологиях [10]. В настоящем исследовании у пациентов с неблагоприятным течением СНсФВ регистрировался повышенный уровень маркера GDF-15.…”

Section: Discussionunclassified

Low-intensity inflammation as a manifestation of comorbidity and a factor in the unfavorable clinical course of heart failure with preserved ejection fraction

Vitt,

Kuzheleva,

Tukish

et al. 2024

Cardiovasc Ther Prev

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Aim. To analyze the prognostic significance of clinical, anamnestic and paraclinical parameters in patients with heart failure with preserved ejection fraction (HFpEF) and non-obstructive coronary artery disease.Material and methods. The study included 54 patients. Cardiac and lung ultrasound was performed. In addition, the level of N-terminal pro-brain natriuretic peptide (NT-proBNP), interleukin-1β, interleukin-18, growth differentiation factor 15 (GDF-15), and cryopyrin was determined. The level of quality of life, anxiety and depression, and adherence to treatment were analyzed.Results. The patients were divided into 2 following groups: group 1 (n=22) with an unfavorable course and group 2 (n=32) with a favorable disease course. Basic echocardiographic parameters, as well as the number of B-lines in lungs, were comparable in both groups. An unfavorable HFpEF course was associated with a longer history of hypertension — 17,5 [10;20] and 7 [5;15] years (p=0,03), smoking — 36,4 and 9,4% (p=0,035), impaired carbohydrate metabolism — 54,5 and 15,6% (p=0,003) and lower adherence to treatment (p=0,02). In group 1, GDF-15 levels were higher than in group 2 — 1841 [1237;3552] vs 1709,5 [1158;2492] pg/ml (p=0,026).Conclusion. Low-intensity subclinical inflammation, the predisposing factors of which are smoking, impaired carbohydrate metabolism, and a long history of hypertension, is associated with higher GDF-15 values in patients with HFpEF and, along with low patient adherence to treatment, has an adverse effect on the clinical course of heart failure.

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Comorbid conditions in patients with chronic heart failure (according to the registry of chronic heart failure in the Tyumen region)

Airapetian,

Lazareva,

Reitblat

et al. 2023

Consilium Medicum

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Background. Comorbidity in patients with chronic heart failure (CHF) makes a major impact to the course of both the underlying and concomitant diseases, significantly worsens the prognosis and increases mortality from cardiovascular diseases. Improving specialized treatment within the framework of a three-tier model of providing medical care to patients with CHF is a healthcare priority. Aim. Analysis of the frequency of comorbid conditions in patients with CHF included in the CHF registry in the Tyumen region. Materials and methods. The study was conducted using the CHF register method, which has been operating in the Tyumen region since January 2020. Medical data from outpatient cards and discharge reports were entered by doctors from 9 polyclinics with an attached population, 1 consultative polyclinic, hospitals, on the basis of which there are outpatient CHF rooms in the structure of polyclinics in the city of Tobolsk, Zavodoukovsk, with. Nizhnyaya Tavda, Yalutorovsk, Tyumen Region, Ural Federal District. The study included medical data of 5741 patients with CHF I–IV functional classes (FC). Gender, clinical-instrumental and laboratory data, non-cardiac and cardiac diseases according to the International Classification of Diseases of the 10th revision were entered into a single map of the CHF registry. Results. In the study sample of patients with CHF, whose average age was 70.0±9.7 years, 2331 (40.6%) were men and 3410 (59.4%) were women. The most common cardiovascular diseases were: coronary artery disease – 55.4%, HD – 22.5% and HRT – 13.5% of cases. Among concomitant diseases of non-cardiac reasons, diabetes mellitus was most often noted – in 31.5% of cases, chronic kidney disease – in 31.1% and chronic obstructive pulmonary disease – in 10% of cases. Concomitant diseases were more common in patients with CHF of functional classes III–IV. Conclusion. Maintaining a register of CHF and analyzing register data makes it possible to assess the required volume of medical care, plan the necessary time, material, economic and organizational resources and take into account possible difficulties in diagnosis, treatment and outpatient monitoring.

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Heart failure and obesity

Cited by 4 publications

References 70 publications

Impact of obesity on heart failure risk is mediated by hypertension: univariable and multivariable Mendelian randomization study

Impact of obesity on heart failure risk is mediated by hypertension: univariable and multivariable Mendelian randomization study

Low-intensity inflammation as a manifestation of comorbidity and a factor in the unfavorable clinical course of heart failure with preserved ejection fraction

Comorbid conditions in patients with chronic heart failure (according to the registry of chronic heart failure in the Tyumen region)

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