Heart dose exposure as prognostic marker after radiotherapy for resectable stage IIIA/B non-small-cell lung cancer: secondary analysis of a randomized trial

Guberina, Maja; Eberhardt, Wilfried; Stuschke, Martin; Gauler, Thomas; Heinzelmann, Frank; Cheufou, Danjouma; Kimmich, Martin; Friedel, Godehard; Schmidberger, Heinz; Darwiche, Kaid; Jendrossek, Verena; Schüler, Martin; Stamatis, Georgios; Pöttgen, Christoph

doi:10.1093/annonc/mdx069

Cited by 40 publications

(33 citation statements)

References 23 publications

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“…It is unclear which regions of the heart are most susceptible for radiation injury. The contribution of heart doses to mortality has not been consistently demonstrated [129][130][131], but it is preferred that heart doses be limited as much as possible.…”

Section: Fractionation For Stereotactic Body Radiotherapy (Sbrt)mentioning

confidence: 99%

European Organization for Research and Treatment of Cancer (EORTC) recommendations for planning and delivery of high-dose, high precision radiotherapy for lung cancer

Ruysscher

Faivre-Finn

Moeller

et al. 2017

Radiotherapy and Oncology

173

119

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Section: Fractionation For Stereotactic Body Radiotherapy (Sbrt)mentioning

confidence: 99%

European Organization for Research and Treatment of Cancer (EORTC) recommendations for planning and delivery of high-dose, high precision radiotherapy for lung cancer

Ruysscher

Faivre-Finn

Moeller

et al. 2017

Radiotherapy and Oncology

173

119

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“…Prior studies in this setting focused primarily on the association between cardiac dosimetry and OS, reaching conflicting conclusions. [10][11][12][13] Furthermore, the data appear limited about the significance of specific types of cardiotoxicities and the relationship with doses to cardiac subvolumes. 14 We thus assessed these relationships within a modern cohort of inoperable NSCLC patients treated with curative standard-dose RT (median prescribed dose, 61.2 Gy) and concurrent chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Dosimetric Predictors of Symptomatic Cardiac Events After Conventional-Dose Chemoradiation Therapy for Inoperable NSCLC

Yegya-Raman

Wang

Kim

et al. 2018

Journal of Thoracic Oncology

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“…5 A large number of studies have shown that RIHD can occur in patients with breast cancer, childhood lymphoma, and other cancers decades after radiotherapy. [6][7][8] Until now, there was no standard diagnostic method for RIHD. Myocardial markers (including brain natriuretic peptide (BNP), pro-BNP, and cTnI), echocardiography, and cardiac magnetic resonance are common methods for diagnosing RIHD.…”

Section: Introductionmentioning

confidence: 99%

Positive association between heart dosimetry parameters and a novel cardiac biomarker, solubleST‐2, in thoracic cancer chest radiation

Zeng

Zhou

et al. 2020

Clinical Laboratory Analysis

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Abbreviations: BNP, B-type natriuretic peptide; DVH, dose-volume histogram; IMRT, intensity-modulated radiotherapy; IQR, interquartile range; LVEF, the left ventricle ejection fraction; MHD, mean heart dose; M-LAD, mean dose of left anterior descending artery; RIHD, radiation-induced heart disease; RT, radiotherapy; sST-2, solubleST-2; VMRT, volumetric-modulated radiotherapy. AbstractBackground: Early screening and diagnosis of radiation-induced heart disease (RIHD)is difficult in patients with chest radiation exposure. sST-2 is involved in myocardial stress or injury. We evaluated the relationship between heart dose parameters and sST-2 changes in chest malignant tumor patients who received chest radiation. Methods:We prospectively collected thoracic malignancy cancer patients who had received chest radiotherapy. Heart dosimetry parameters were extracted from the treatment planning system. sST-2 was measured at baseline, the middle stage, and after radiotherapy (recorded as pre-ST-2, mid-ST-2, and post-ST-2). sST-2 change rate was calculated. Scatter plots showed the relationship between cardiac dose parameters and ST-2 change rate. Multiple regression was used to analyze the relationship between cardiac dose parameters and ST-2 change rate. Results:Totally, 60 patients were enrolled. The mean V 5 , V 10 , V 20 , V 30 , V 40 , and MHD was 60.93 ± 27.79%, 51.43 ± 25.44%, 39.17 ± 21.75%, 28.07 ± 17.15%,18.66 ± 12.18%, and 18.60 ± 8.63 Gy, respectively. The median M-LAD was 11.31 (IQR 3.33-18.76) Gy. The mean pre-ST-2, mid-ST-2, and post-ST-2 was 5.1 ± 3.8, 6.4 ± 3.9, and 7.6 ± 4.4, respectively. sST-2 was elevated with thoracic irradiation (P < .001). Multivariate linear regression analyses showed that V 5 , V 10 , V 20 , and MHD were independently and positively associated with ST-2 change rate (β = .04, .04, .04, and .10, respectively, all P < .05). Conclusion: Serum sST-2 levels were elevated over time during radiotherapy. V 5 , V 10 , V 20 and MHD were independently and positively associated with the elevated ST-2 change rate. K E Y W O R D S cardiac biomarker, heart dosimetry parameters, radiation-induced heart disease, radiotherapy, sST-2 S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Zeng Z-M, Xu P, Zhou S, et al. Positive association between heart dosimetry parameters and a novel cardiac biomarker, solubleST-2, in thoracic cancer chest radiation. J Clin Lab Anal. 2020;34:e23150. https ://doi.

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Heart dose exposure as prognostic marker after radiotherapy for resectable stage IIIA/B non-small-cell lung cancer: secondary analysis of a randomized trial

Abstract: Z5 - 22461/2 - 2002-017 (German Federal Office for Radiation Protection).

Cited by 40 publications

References 23 publications

European Organization for Research and Treatment of Cancer (EORTC) recommendations for planning and delivery of high-dose, high precision radiotherapy for lung cancer

European Organization for Research and Treatment of Cancer (EORTC) recommendations for planning and delivery of high-dose, high precision radiotherapy for lung cancer

Dosimetric Predictors of Symptomatic Cardiac Events After Conventional-Dose Chemoradiation Therapy for Inoperable NSCLC

Positive association between heart dosimetry parameters and a novel cardiac biomarker, solubleST‐2, in thoracic cancer chest radiation

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