Heart Disease Following Radiation

Cohn, Keith; Stewart, James R.; Fajardo, Luis F.; Hancock, Elizabeth

doi:10.1097/00005792-196705000-00003

Cited by 244 publications

(42 citation statements)

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“…There has been general recognition since the mid-1960s that high doses of radiation, administered as a consequence of the treatment of patients with cancer, can cause damage to the heart and pericardium (21). In the treatment of localized malignant disease, for example, Hodgkin's disease and carcinoma of the breast, the dose distribution to the heart is highly nonuniform.…”

Section: Cancer Treatmentmentioning

confidence: 99%

Radiation as a Risk Factor for Cardiovascular Disease

Baker

Moulder

Hopewell

2011

Antioxidants & Redox Signaling

107

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Humans are continually exposed to ionizing radiation from terrestrial sources. The two major contributors to radiation exposure of the U.S. population are ubiquitous background radiation and medical exposure of patients. From the early 1980s to 2006, the average dose per individual in the United States for all sources of radiation increased by a factor of 1.7-6.2 mSv, with this increase due to the growth of medical imaging procedures. Radiation can place individuals at an increased risk of developing cardiovascular disease. Excess risk of cardiovascular disease occurs a long time after exposure to lower doses of radiation as demonstrated in Japanese atomic bomb survivors. This review examines sources of radiation (atomic bombs, radiation accidents, radiological terrorism, cancer treatment, space exploration, radiosurgery for cardiac arrhythmia, and computed tomography) and the risk for developing cardiovascular disease. The evidence presented suggests an association between cardiovascular disease and exposure to low-to-moderate levels of radiation, as well as the well-known association at high doses. Studies are needed to define the extent that diagnostic and therapeutic radiation results in increased risk factors for cardiovascular disease, to understand the mechanisms involved, and to develop strategies to mitigate or treat radiation-induced cardiovascular disease. Antioxid. Redox Signal. 15, 1945Signal. 15, -1956

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Section: Cancer Treatmentmentioning

confidence: 99%

Radiation as a Risk Factor for Cardiovascular Disease

Baker

Moulder

Hopewell

2011

Antioxidants & Redox Signaling

107

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“…18,19,20 Pericarditis may occur many months or years after completion of a course of radiation therapy.…”

Section: Radiotherapymentioning

confidence: 99%

Oncologic Emergencies

Hossen

Rabbani

Hasan

2014

J. Bangladesh Coll. Phys.

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“…Pericardial disease is a well-recognized complication of therapeutical mediastinal ir radiation [1][2][3]. The prevalence of radiationinduced pericardial disease has been esti mated to be 6-30% in various series [2,3].…”

Section: Introductionmentioning

confidence: 99%

Postpericardiectomy Syndrome in a Patient with Radiation-Induced Pericardial Effusion

Ferrannini¹,

Pentimone²

1983

Cardiology

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A 30-year-old man with mild exertional dyspnea of recent (2 months) onset was found to have a massive pericardial effusion. The patient had received mediastinal irradiation for Hodgkin’s disease over 9 years previously. No evidence of recurrent lymphoma or other causes of pericarditis could be found. Following subtotal pericardiectomy, the patient developed a syndrome characterized by precordial discomfort, low-grade fever, tachycardia, and friction rubs. The electrocardiogram, normal preoperatively, showed diffusely negative T waves. Antimyocardial antibodies appeared in the serum. The syndrome, a hitherto unrecognized sequela of pericardiectomy, is interpreted as a mediastinoepicarditis, of possibly autoimmune origin.

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Heart Disease Following Radiation

Cited by 244 publications

References 0 publications

Radiation as a Risk Factor for Cardiovascular Disease

Radiation as a Risk Factor for Cardiovascular Disease

Oncologic Emergencies

Postpericardiectomy Syndrome in a Patient with Radiation-Induced Pericardial Effusion

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