Heart contains receptors for dihydrotestosterone but not testosterone: Possible role in the sex differential in coronary heart disease

Sheridan, Peter J.; McGill, Henry C.; Aufdemorte, Thomas B.; Triplett, R. Gilbert; Holt, Richard G.

doi:10.1002/ar.1092230410

Cited by 41 publications

(13 citation statements)

References 36 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…dance. 31,32 Thus, it is important to determine whether binding of androgens to androgen receptors in cardiac myocytes actually can produce hypertrophy. It is known that in skeletal muscle, androgenic steroids can produce a hypertrophic effect.…”

Section: Functional Analysis Of Signal Transduction By the Androgen Rmentioning

confidence: 99%

Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes

et al. 1998

View full text Add to dashboard Cite

Background-The role of androgens in producing cardiac hypertrophy by direct action on cardiac myocytes is uncertain.Accordingly, we tested the hypothesis that cardiac myocytes in adult men and women express an androgen receptor gene and that myocytes respond to androgens by a hypertrophic response. Methods and Results-We used reverse transcription-polymerase chain reaction methods to demonstrate androgen receptor transcripts in multiple tissues and [ 3 H]phenylalanine incorporation and atrial natriuretic peptide secretion as markers of hypertrophy in cultured rat myocytes. Messenger RNA encoding androgen receptors was detected in myocytes of male and female adult rats, neonatal rat myocytes, rat heart, dog heart, and infant and adult human heart. Both testosterone and dihydrotestosterone produced a robust receptor-specific hypertrophic response in myocytes, determined by indices of protein synthesis and atrial natriuretic peptide secretion. Conclusions-Androgen receptors are present in cardiac myocytes from multiple species, including normal men and women, in a context that permits androgens to modulate the cardiac phenotype and produce hypertrophy by direct, receptor-specific mechanisms. There are clinical implications for therapeutic or illicit use of androgens in humans.(Circulation. 1998;98:256-261.)

show abstract

Section: Functional Analysis Of Signal Transduction By the Androgen Rmentioning

confidence: 99%

Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes

et al. 1998

View full text Add to dashboard Cite

show abstract

“…Receptors for dihydrotestosterone have been found in mouse and baboon heart muscle and endothelial cells. 19,20 In rats, dihydrotestosterone may directly accelerate atherosclerosis by stimulating the proliferation of vascular smooth muscle cells. 21 Administration of testosterone was associated with a significant increase in platelet thromboxane A 2 receptor density in rodents.…”

Section: Commentmentioning

confidence: 99%

Male Pattern Baldness and Coronary Heart Disease

Lotufo¹,

Chae²,

Ajani³

et al. 2000

Arch Intern Med

133

110

View full text Add to dashboard Cite

Objective: To examine the association between male pattern baldness and the risk of coronary heart disease (CHD) events.Design, Setting, and Participants: Retrospective cohort study among 22 071 US male physicians aged 40 to 84 years enrolled in the Physicians' Health Study. Of these, 19 112 were free of CHD at baseline and completed a questionnaire at the 11-year follow-up concerning their pattern of hair loss at age 45 years. Response options included no hair loss, frontal baldness only, or frontal baldness with mild, moderate, or severe vertex baldness. Main Outcome Measures:Coronary heart disease events defined as nonfatal myocardial infarction (MI), angina pectoris, and/or coronary revascularization.Results: During 11 years of follow-up, we documented 1446 CHD events in this cohort. Compared with men with no hair loss, those with frontal baldness had an ageadjusted relative risk (RR) of CHD of 1.09 (95% confidence interval [CI], 0.94-1.25), while those with mild, moderate, or severe vertex baldness had RRs of 1.23 (95% CI, 1.05-1.43), 1.32 (95% CI, 1.10-1.59), and 1.36 (95% CI, 1.11-1.67), respectively (P for trend, Ͻ.001). Multivariate adjustment for age, parental history of MI, height, body mass index (weight in kilograms divided by the square of the height in meters as a continuous variable), smoking, history of hypertension, diabetes, high cholesterol level, physical activity, and alcohol intake did not materially alter these associations. Results were similar when nonfatal MI, angina, and coronary revascularization were examined separately, and when events were analyzed among men older and younger than 55 years at baseline. Vertex baldness was more strongly associated with CHD risk among men with hypertension (multivariate RR, 1.79; 95% CI, 1.31-2.44) or high cholesterol levels (multivariate RR, 2.78; 95% CI, 1.09-7.12). Conclusion:Vertex pattern baldness appears to be a marker for increased risk of CHD events, especially among men with hypertension or high cholesterol levels.

show abstract

“…The independence of the effect of h testosterone to A LVM in males raises the possibility that androgens may directly effect LVM. This possibility has been suggested in reports that identify specific receptor sites for androgens in primate and human myocardial muscle (McGill and Sheridan, 1981;Sheridan et al, 1989). Alternatively the association between A testosterone and A LVM in males may simply serve as an early indicator of puberty and general bodily growth and maturation.…”

Section: Cross Sectional Datamentioning

confidence: 87%

Fat-free mass as a determinant of left ventricular mass in children: The Muscatine Study

1996

View full text Add to dashboard Cite

To assess the relationship of somatic growth to heart growth, associations were examined among body composition, blood pressure, androgens, sexual maturation, and left ventricular mass (LVM) during early puberty in 123 children, 7–12 years of age. All subjects underwent anthropometry, random‐zero blood pressure measurements, hormone determination of androgens, physician's examination to determine sexual maturation, and echocardiographic examinations. Subjects then repeated these procedures 1 year later. Data were examined cross‐sectionally (year 1, year 2) and longitudinally (Δ = year 2 minus year 1). The strongest correlations with LVM were among weight and fat‐free mass (FFM) (r = 0.60 to 0.83). In males, cross‐sectional predictors of LVM were FFM and stage of sexual maturation (r2 = 0.49 to 0.65). Δ LVM was best predicted in males by Δ testosterone and Δ weight (r2 = 0.22). In females, FFM was the strongest cross‐sectional predictor of LVM (r2 = 0.70). Δ LVM was best predicted in females by Δ FFM and Δ height (r2 = 0.27). When males and females were pooled, gender did not predict LVM in any of the models. The results suggest that FFM is an important predictor of LVM in circumpubertal children. Boys and girls do not significantly differ in LVM once normalized for FFM. © 1996 Wiley‐Liss, Inc.

show abstract

Heart contains receptors for dihydrotestosterone but not testosterone: Possible role in the sex differential in coronary heart disease

Cited by 41 publications

References 36 publications

Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes

Androgen Receptors Mediate Hypertrophy in Cardiac Myocytes

Male Pattern Baldness and Coronary Heart Disease

Fat-free mass as a determinant of left ventricular mass in children: The Muscatine Study

Contact Info

Product

Resources

About