Heart and mind: (1) relationship between cardiovascular and psychiatric conditions

Shah, S U; White, Angela; White, Susie; Littler, W. A.

doi:10.1136/pgmj.2003.014662

Cited by 44 publications

(33 citation statements)

References 121 publications

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“…Phobic anxiety was found to be significantly related with a nearly fourfold increase in the relative risk of fatal CAD [11,12]. Chronic emotional distress, especially type-D personality pattern, characterised by increased negative affectivity and social inhibition, was found to be predictive of worse outcomes in patients with CAD [13].…”

Section: Discussionmentioning

confidence: 83%

“…It is well known that a consistent endocrine system plays a significant role in the overall coherence and normal functioning of the cardiovascular system. Stressful experiences and emotions impress the heart directly through the autonomic nervous system and indirectly through neuroendocrine pathways [12]. Psychological stress results in hypothalamic-adrenocortical and sympathoadrenal hyperactivity [23].…”

Section: Discussionmentioning

confidence: 99%

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Atrial electromechanical delay analysed by tissue Doppler echocardiography is prolonged in patients with generalised anxiety disorders

Öksüz¹,

Yarlıoğlueş²,

Öztürk³

et al. 2017

Kardiol Pol

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A b s t r a c tBackground: It has been shown that psychological status is associated with the likelihood of atrial fibrillation (AF). Prolongation of the duration of atrial electromechanical delay (AEMD) is known to be a precursor for AF development.Aim: Therefore, we aimed to evaluate AEMD in patients with anxiety disorder. Methods:In this prospective study, a total of 82 anxiety disorder and 80 healthy subjects were enrolled. Symptoms of anxiety were evaluated by using the Hamilton Anxiety Rating Scale (HAM-A). P-wave dispersion (PWD) was measured on a 12-lead electrocardiogram. Both intra-and inter-AEMD were measured with tissue Doppler imaging. Results:Basal characteristics were similar between the two groups. PWD, inter-and right intra-AEMD were significantly prolonged in patients with anxiety disorders, compared to the control group (p < 0.05). In the correlation analysis, HAM-A was significantly and moderately correlated with right intra-and inter-AEMD, and PWD. Conclusions:Patients suffering from anxiety disorders are characterised by prolonged AEMD, which can provide significant contributions to evaluate the risk for AF development in this group.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Atrial electromechanical delay analysed by tissue Doppler echocardiography is prolonged in patients with generalised anxiety disorders

Öksüz¹,

Yarlıoğlueş²,

Öztürk³

et al. 2017

Kardiol Pol

View full text Add to dashboard Cite

show abstract

“…In the study made by Sanner et al in 2013, the authors could not find a linear correlation. The study concludes that the correlation between the thrombocyte serotonin, depressive symptoms and the acute coronary syndrome is not yet fully explained, but there is a number of clues that suggest such correlation [51]. The SIPPS act in such manner that their action reduces the level of the available serotonin, which is reflected in lower levels of serotonin in thrombocytes.…”

Section: Discussionmentioning

confidence: 99%

The role of thrombocyte serotonin system and some thrombocyte characteristics in treatment of depressive patients with cardiovascular diseases

Kostanjšak¹,

Zdunić

2017

Alcoholism and Psychiatry Research

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-Serotonin has an important role in the development of depressive disorders. Bearing in mind that direct testing of central nervous system is unavailable to researchers due to the inability to reach the samples, ever greater attention is given to the peripheral systems that can help us diagnose and detect changes of the disease, but also follow the course of its treatment and recovery. Thrombocyte is a blood cell that contains serotonin lodged in its delta granules. Thrombocyte serotonin system is similar, although not the same as the serotonin system in central nervous system. The most important differences are that in thrombocytes, serotonin is broken down by the enzyme monoaminooxidase B (MAO-B), while that function in neuron is carried out by monoaminooxidase A (MAO-A) and that a thrombocyte cannot synthetize serotonin itself, because it lacks tryptophan hydroxylase. Nowadays, in the treatment of depressive disorders, mostly the selective inhibitors of serotonin uptake (SIPPS) are being used. The research has proved that therapy with those medications changes the concentration of serotonin in thrombocytes and changes the values of some thrombocyte indices. The thrombocyte serotonin is a powerful vasoconstrictor, which increases the cardiovascular risk and the probability of thrombogenesis. The mean volume of thrombocytes (MPV) is a positive index of thrombocyte activity and the increase of MPV represents an independent risk factor for the development of cardiovascular diseases. It is of enormous significance to recognize the depression in patients who suffer from cardiovascular diseases. Depression interferes with the recovery of those patients, because it reduces the personal engagement in it and disturbs patients' compliance and the motivation for treatment. Besides the fact that the treatment with SIPPS leads to the regression of symptoms of depression, it also changes the concentration of thrombocyte serotonin and the mean volume of thrombocytes towards the values that reduce their role in pathogenesis of cardiovascular diseases, thus reducing the risk of re-occurrence of cardiovascular incidents and improving the patients' recovery.

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“…When sex differences and age effects are taken into account and large samples are used, most studies find dose-response-positive relationships between type A-related characteristics and cardiovascular disease-related symptoms. It is suggested that type A behavior pattern might predispose people to experience coronary disease through both unhealthy daily lifestyle behaviors-obesity, alcoholism, social isolation, smoking, and pathophysiological effectshigher blood pressure and heart rate responses, hypercortisolemia, high circulating catecholamines, and increased platelet reactivity (14,15).…”

Section: Introductionmentioning

confidence: 99%

Genetic and Environmental Influences on Type A Behavior Pattern: Evidence From Twins and Their Parents in The Netherlands Twin Register

Rebollo

Boomsma

2006

Psychosomatic Medicine

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Objective: There is a dose-response positive relationship between type A behavior (TABP) and cardiovascular disease-related symptoms. Estimates of heritability for TABP from previous studies vary; this might be explained by limitations in the sizes and compositions of the samples. Methods: This study combines a large sample size, twin and parental, data from males and females, two generations of young adults and older adults, and the use of structural equation modeling (SEM) and full information maximum likelihood (FIML) estimation. To assess TABP, the Jenkins Activity Survey (JAS) was collected from MZ and DZ twins and their parents (n ϭ 1670 twin families). Structural equation modeling is used to evaluate and estimate the effects of additive and nonadditive genetic effects, nonshared environmental effects, and competitive sibling interaction. Results: Forty-five percent of the variance in TABP was the result of genetic factors (28% were additive and 17% were nonadditive). The remaining 55% of the variance was explained by environmental factors not shared by the members of the same family. Competitive sibling interaction effects were not significant. There was no evidence of sex differences either in variances or means. Conclusion: Understanding the sources of variance on TABP is important for therapy and prevention. According to the present results, the relevant environmental factors for the development of TABP are not shared by the members of the same family. The genetic portion of the variance is also worth considering for therapeutic purposes. Although the genetic code cannot be altered, its effects on behavior may be modifiable through the treatment of the biological mediators. Key words: type A behavior pattern, risk of CHD, JAS, sibling interaction, twin studies, parents-offspring.TABP ϭ type A behavior pattern; JAS ϭ Jenkins Activity Survey; FIML ϭ full information maximum likelihood; CVD and CHD ϭ Cardiovascular and Coronary Heart Disease; MZM ϭ monozygotic males; MZF ϭ monozygotic females; DZM ϭ dizygotic males; DZF ϭ dizygotic females; OSMF ϭ opposite sex male first born and female second born; OSFM ϭ opposite sex female first born and male second born; DF ϭ degrees of freedom; SEM ϭ structural equation modeling; ADEi:A ϭ additive genetic effects; D ϭ dominance genetic effects; E ϭ nonshared environmental effects; i ϭ sibling interaction effects; CI ϭ confidence interval.

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Heart and mind: (1) relationship between cardiovascular and psychiatric conditions

Cited by 44 publications

References 121 publications

Atrial electromechanical delay analysed by tissue Doppler echocardiography is prolonged in patients with generalised anxiety disorders

Atrial electromechanical delay analysed by tissue Doppler echocardiography is prolonged in patients with generalised anxiety disorders

The role of thrombocyte serotonin system and some thrombocyte characteristics in treatment of depressive patients with cardiovascular diseases

Genetic and Environmental Influences on Type A Behavior Pattern: Evidence From Twins and Their Parents in The Netherlands Twin Register

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