Heart and liver regeneration in zebrafish using silver nanoparticle synthesized from Turbinaria conoides – In vivo

Ali, M. Syed; Anuradha, V.; Yogananth, N.; Krishnakumar, S.

doi:10.1016/j.bcab.2018.10.013

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…In the same study, chemically synthesized AgNPs showed insignificant anticataractogenic effects [ 16 ]. AgNPs synthesized using an aqueous extract of Turbinaria conoides , a brown seaweed, showed heart and liver regeneration effects in zebrafish ( Danio rerio ) as revealed by histological studies [ 17 ]. Overall, in contrast to “naked” AgNPs, the phytofunctionalized ones have important advantages such as improved bioactivity, higher stability, and reduced toxicity [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Synthesized from Abies alba and Pinus sylvestris Bark Extracts: Characterization, Antioxidant, Cytotoxic, and Antibacterial Effects

et al. 2023

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In recent years, phytofunctionalized AgNPs have attracted great interest due to their remarkable biological activities. In the present study, AgNPs were synthesized using Abies alba and Pinus sylvestris bark extracts. The chemical profile of these bark extracts was analyzed by LC-HRMS/MS. As a first step, the synthesis parameters (pH, AgNO3 concentration, ratio of bark extract and AgNO3, temperature, and reaction time) were optimized. The synthesized AgNPs were characterized by ATR-FTIR spectroscopy, DLS, SEM, EDX, and TEM. Their antioxidant, cytotoxic, and antibacterial properties were evaluated by the DPPH, ABTS, MTT, and broth microdilution assays, respectively. Abies alba and Pinus sylvestris bark extract-derived AgNPs were well-dispersed, spherical, small (average particle size of 9.92 and 24.49 nm, respectively), stable (zeta potential values of −10.9 and −10.8 mV, respectively), and cytotoxic to A-375 human malignant melanoma cells (IC50 = 2.40 ± 0.21 and 6.02 ± 0.61 μg/mL, respectively). The phytosynthesized AgNPs also showed antioxidant and antibacterial effects.

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Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Synthesized from Abies alba and Pinus sylvestris Bark Extracts: Characterization, Antioxidant, Cytotoxic, and Antibacterial Effects

et al. 2023

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“…Zebra fish are considered a good teleost model for developmental and molecular studies (Han et al, 2021). Zebra fish was chosen because it is a model animal that is considered to have similarities in physiological functions and genes with most individuals (Santoriello and Zon, 2012;Ali et al, 2021). Zebra fish are also being used for scientific research as a test animal model for vertebrates increasingly.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis from Three Different Methanolic Extracts of Red Ginger (Zingiber officinale var. Rubrum) Against LC50 Treatment of Zebra Fish as Model Fish

Febriani

Widodo

Faqih

2023

JAFH

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Red ginger (Zingiber officinale var. Rubrum) as one of the Indonesian spices has so many important roles, especially in the health sector as a medicinal plant, which has many active compounds including phenols, alkaloids, flavonoids, steroids and tannins. From some researches before, we can know that plants which grow in different places or locations have different tolerances generally. That statements can show that they have different content in their constituent metabolites definitely. Therefore, phytochemical analysis is needed to analyze the content of each red ginger (Z. officinale var. Rubrum) from three locations such as Red ginger (Z. officinale var. Rubrum) from Batu, Malang (RGB), Plaosan, Magetan (RGP) and Simalungun, Medan (RGS) to analyze each content its contains. Also, perform LC50 was needed for analyzing its effect on Zebra fish (Danio rerio) as a model fish. For this research, we use an experimental study with a Completely Randomized Factorial Design (CRFD) method that has two independent variable such as different dosage and type of red ginger (Z. officinale var. Rubrum). In this study, from five dosages (10 mg/l; 20 mg/l; 30 mg/l; 40 mg/l; 50 mg/l) and three types of red ginger (Z. officinale var. Rubrum) treatment, it found that the highest mortality and lowest survival rate were at the highest dosage (50 mg/l) in RGB and extreme increase or decrease in the curve is found in RGP treatment.

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“…Plant extracts act not only as reducing and/or capping agents, but also as modulators of the biological effects of nanosized metallic Ag [ 5 ]. Thus, AgNPs synthesized using plant extracts or pure phytochemicals have been reported to develop a wide range of biological activities, such as antibacterial, antifungal and antiviral [ 6 ], anti-inflammatory [ 7 ], antioxidant [ 5 , 7 ], wound healing [ 8 ], anticancer [ 1 , 3 ], anticoagulant [ 9 ], cardioprotective [ 10 ], liver protective [ 10 ], antidiabetic [ 11 ], anti-cataractogenic [ 12 ] and anti-ageing [ 13 ] activities.…”

Section: Introductionmentioning

confidence: 99%

Phyto-Functionalized Silver Nanoparticles Derived from Conifer Bark Extracts and Evaluation of Their Antimicrobial and Cytogenotoxic Effects

et al. 2021

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Silver nanoparticles synthesized using plant extracts as reducing and capping agents showed various biological activities. In the present study, colloidal silver nanoparticle solutions were produced from the aqueous extracts of Picea abies and Pinus nigra bark. The phenolic profile of bark extracts was analyzed by liquid chromatography coupled to mass spectrometry. The synthesis of silver nanoparticles was monitored using UV-Vis spectroscopy by measuring the Surface Plasmon Resonance band. Silver nanoparticles were characterized by attenuated total reflection Fourier transform infrared spectroscopy, Raman spectroscopy, dynamic light scattering, scanning electron microscopy, energy dispersive X-ray and transmission electron microscopy analyses. The antimicrobial and cytogenotoxic effects of silver nanoparticles were evaluated by disk diffusion and Allium cepa assays, respectively. Picea abies and Pinus nigra bark extract derived silver nanoparticles were spherical (mean hydrodynamic diameters of 78.48 and 77.66 nm, respectively) and well dispersed, having a narrow particle size distribution (polydispersity index values of 0.334 and 0.224, respectively) and good stability (zeta potential values of −10.8 and −14.6 mV, respectively). Silver nanoparticles showed stronger antibacterial, antifungal, and antimitotic effects than the bark extracts used for their synthesis. Silver nanoparticles obtained in the present study are promising candidates for the development of novel formulations with various therapeutic applications.

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Heart and liver regeneration in zebrafish using silver nanoparticle synthesized from Turbinaria conoides – In vivo

Cited by 7 publications

References 14 publications

Silver Nanoparticles Synthesized from Abies alba and Pinus sylvestris Bark Extracts: Characterization, Antioxidant, Cytotoxic, and Antibacterial Effects

Silver Nanoparticles Synthesized from Abies alba and Pinus sylvestris Bark Extracts: Characterization, Antioxidant, Cytotoxic, and Antibacterial Effects

Phytochemical Analysis from Three Different Methanolic Extracts of Red Ginger (Zingiber officinale var. Rubrum) Against LC50 Treatment of Zebra Fish as Model Fish

Phyto-Functionalized Silver Nanoparticles Derived from Conifer Bark Extracts and Evaluation of Their Antimicrobial and Cytogenotoxic Effects

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