Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae

Huang, Yuyu; Yu, Hao-Ran; Liang, Min; Hou, Shule; Chen, Junmin; Zhang, Fan; Sun, Xiayu; Jia, Hong-Ti; Yang, Jun

doi:10.2147/dddt.s318117

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…At five weeks after CI, they measured a minor ABR threshold shift in favor of the PCL-DEX-coated electrode when compared to the uncoated electrode. They also observed reduced cochlear fibrosis and better preservation of the SGNs [92].…”

Section: Drug-eluting Electrodesmentioning

confidence: 84%

Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review

et al. 2022

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Hearing loss is the most common neurosensory disorder, and with the constant increase in etiological factors, combined with early detection protocols, numbers will continue to rise. Cochlear implantation has become the gold standard for patients with severe hearing loss, and interest has shifted from implantation principles to the preservation of residual hearing following the procedure itself. As the audiological criteria for cochlear implant eligibility have expanded to include patients with good residual hearing, more attention is focused on complementary development of otoprotective agents, electrode design, and surgical approaches. The focus of this review is current aspects of preserving residual hearing through a summary of recent trends regarding surgical and pharmacological fundamentals. Subsequently, the assessment of new pharmacological options, novel bioactive molecules (neurotrophins, growth factors, etc.), nanoparticles, stem cells, and gene therapy are discussed.

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Section: Drug-eluting Electrodesmentioning

confidence: 84%

Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review

et al. 2022

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“…Seventeen studies 3,5,10,22,27–39 used animal models. These studies were published between 2008 and 2021.…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen studies 3,5,10,22,[27][28][29][30][31][32][33][34][35][36][37][38][39] The follow-up of animals ranged from 13 to 365 days, with an average follow-up of 123 days. Study characteristics for both human and animal studies included in this review are summarized in Table 1.…”

Section: Description Of Studiesmentioning

confidence: 99%

Outcomes following cochlear implantation with eluting electrodes: A systematic review

Fleet,

Nikookam,

Radotra

et al. 2024

Laryngoscope Investig Oto

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ObjectivesTo establish audiological and other outcomes following cochlear implantation in humans and animals with eluting electrodes.MethodsSystematic review and narrative synthesis. Databases searched (April 2023): MEDLINE, EMBASE, CENTRAL, ClinicalTrials.gov, and Web of Science. Studies reporting outcomes in either humans or animals following cochlear implantation with a drug‐eluting electrode were included. No limits were placed on language or year of publication. Risk of bias assessment was performed on all included studies using either the Brazzelli or Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) assessment tools. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) 2020 statement.ResultsSearches identified 146 abstracts and 108 full texts. Of these, 18 studies met the inclusion criteria, reporting outcomes in 523 animals (17 studies) and 24 humans (1 study). Eluting electrodes included dexamethasone (16 studies), aracytine (1 study), nicotinamide adenine dinucleotide (1 study), the growth factors insulin‐like growth factor 1 (IGF1) and hepatocyte growth factor (HGF) (1 study), and neurotrophin‐3 (1 study). All included studies compare outcomes following implantation with an eluting electrode with a control non‐eluting electrode. In the majority of studies, audiological outcomes (e.g., auditory brainstem response threshold) were superior following implantation with an eluting electrode compared with a standard electrode. Most studies which investigated post‐implantation impedance reported lower impedance following implantation with an eluting electrode. The influence of eluting electrodes on other reported outcomes (including post‐implantation cochlear fibrosis and the survival of hair cells and spiral ganglion neurons) was more varied across the included studies.ConclusionsEluting electrodes have shown promise in animal studies in preserving residual hearing following cochlear implantation and in reducing impedance, though data from human studies remain lacking. Further in‐human studies will be required to determine the clinical usefulness of drug‐eluting cochlear implants as a future treatment for sensorineural hearing loss.

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“…Because the electrode of a CI is inserted directly into the inner ear, the same approach can be used as a drug delivery modality (Fig. 7) [96][97][98][99][100]. This means that rapid progress might be possible in the field of otic organoid-based cell therapy.…”

Section: Otic Organoids Versus Cochlear Implantationmentioning

confidence: 99%

Development of otic organoids and their current status

Kim

et al. 2023

Organoid

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The inner ear is responsible for both hearing and balance in the body, and since the initial development of otic (inner ear) organoids from mouse pluripotent stem cells (PSCs) in 2013, significant advances have been made in this field. Bone morphogenetic proteins, fibroblast growth factors, and Wnt agonists, which are signaling molecules in the early development of the inner ear, can induce PSCs into the otic fate. In the inner ear, hair cells and the surrounding supporting cells are essential for proper function and structure. Recent advancements in otic organoid research have enabled the generation of cells that closely resemble these key components. The developed otic organoids contain both hair cell-like cells and supporting cells, which have been confirmed to have the intrinsic function of those cell types. Otic organoids have been used for disease modeling and are expected to be more widely applied in various areas of research on the inner ear. However, the otic organoids developed to date remain immature. Although they mimic hair cells, their properties resemble vestibular (balance) hair cells more closely than cochlear (auditory) hair cells. The ultimate goal of research on the inner ear is hearing restoration and prevention; thus, it is essential to produce otic organoids that contain cochlear hair cells. In addition, the organ of Corti—a cell arrangement unique to the cochlea—has not yet been simulated. Along with a description of the current status of otic organoids, this review article will discuss future directions for otic organoids in inner ear research.

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Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae

Cited by 3 publications

References 25 publications

Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review

Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review

Outcomes following cochlear implantation with eluting electrodes: A systematic review

Development of otic organoids and their current status

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