Hearing loss following exposure during development to polychlorinated biphenyls: A cochlear site of action

Crofton, Kevin M.; Ding, Dalian; Padich, Robert; Taylor, Miles G.; Henderson, Donald

doi:10.1016/s0378-5955(00)00062-9

Cited by 89 publications

(78 citation statements)

References 41 publications

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“…This is in line with effects observed so far concerning the influence of thyroid hormone deficiencies on auditory thresholds (Goldey et al, 1995a). In addition, the results shown for Aroclor 1254 treated animals are in line with results presented by Goldey et al (1995b) and were related to hair cell loss in the apical part of the cochlea (Crofton et al 2000a). Animals treated with 4-OH-CB107 showed no increase in BAEP thresholds, suggesting that this metabolite exerts no deleterious effects on the cochlea.…”

Section: Discussionsupporting

confidence: 90%

Developmental Exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107): Long-Term Effects on Brain Development, Behavior, and Brain Stem Auditory Evoked Potentials in Rats

Meerts

Lilienthal²,

Hoving³

et al. 2004

Toxicological Sciences

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In the present study the developmental neurotoxic effects of the PCB metabolite 4-OH-2,3,3 0 ,4 0 ,5-pentachlorobiphenyl (4-OH-CB107) were compared with effects caused by a mixture of parent polychlorinated biphenyl (PCB) congeners (Aroclor 1254). Pregnant female Wistar rats were exposed to 0.5 or 5 mg 4-OH-CB107, or 25 mg Aroclor 1254 per kg body weight from gestation days 10 to 16. Plasma thyroid hormone levels were significantly decreased in the offspring of all treatment groups at postnatal day 4 (PND 4). Behavioral experiments using an open field paradigm revealed an impaired habituation in male offspring of all treatment groups at PND 130. Passive avoidance experiments indicated significant influences on the time course of step-down latencies across trials in exposed male rats. Catalepsy induced by haloperidol showed increases in latencies to movement onset in female offspring exposed to 0.5 mg 4-OH-CB107 compared to Aroclor 1254 treated offspring at PND 168-175. Male offspring exposed to 4-OH-CB107 or Aroclor 1254 showed decreases in latencies compared to control animals. Brain stem auditory evoked potentials (BAEPs) measured at PND 300-310 showed significant increases in auditory thresholds in the low frequency range between Aroclor 1254 and 4-OH-CB107 (5 mg/kg bw) treated animals. Measurements of neurotransmitter levels revealed effects of Aroclor 154 exposure on both the dopaminergic and the serotonergic systems, whereas 4-OH-CB107 exposure affected dopaminergic and noradrenergic systems, with slight but not significant effects on the serotonergic system. These results indicate that 4-OH-CB107 is able to induce long-term effects on behavior and neurodevelopment. The observed effects for 4-OH-CB107 are similar to, but in some aspects different from, the effects observed after Aroclor 1254 exposure.

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Section: Discussionsupporting

confidence: 90%

Developmental Exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107): Long-Term Effects on Brain Development, Behavior, and Brain Stem Auditory Evoked Potentials in Rats

Meerts

Lilienthal²,

Hoving³

et al. 2004

Toxicological Sciences

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“…Previous studies of PCB toxicity have identified that developmental exposure to a complex mixture of coplanar and noncoplanar PCBs known as Aroclor 1254 produces cochlear hair loss that caused peripheral hearing impairment (43,44), which has been attributed in part (45) to reductions in thyroid hormone (hypothyroidism). The present study showed that developmental exposure to a noncoplanar PCB can disrupt the topographic organization and the critical period plasticity that underlies normal postnatal auditory system development in the absence of detectable peripheral hearing impairment.…”

Section: Discussionmentioning

confidence: 99%

Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex

Kenet

Froemke

Schreiner

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Noncoplanar polychlorinated biphenyls (PCBs) are widely dispersed in human environment and tissues. Here, an exemplar noncoplanar PCB was fed to rat dams during gestation and throughout three subsequent nursing weeks. Although the hearing sensitivity and brainstem auditory responses of pups were normal, exposure resulted in the abnormal development of the primary auditory cortex (A1). A1 was irregularly shaped and marked by internal nonresponsive zones, its topographic organization was grossly abnormal or reversed in about half of the exposed pups, the balance of neuronal inhibition to excitation for A1 neurons was disturbed, and the critical period plasticity that underlies normal postnatal auditory system development was significantly altered. These findings demonstrate that developmental exposure to this class of environmental contaminant alters cortical development. It is proposed that exposure to noncoplanar PCBs may contribute to common developmental disorders, especially in populations with heritable imbalances in neurotransmitter systems that regulate the ratio of inhibition and excitation in the brain. We conclude that the health implications associated with exposure to noncoplanar PCBs in human populations merit a more careful examination.autism ͉ brain development ͉ cortical maps ͉ environment ͉ sensory systems

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“…[150][151][152] Animal data suggest that halogenated hydrocarbon-induced hearing impairments are the sequelae of thyroid gland disorders caused by some of these substances. 153,154 In addition, Powers et al 155 proposed in 2006 that polychlorinated biphenyls could have a direct adverse effect on the outer hair cell function.…”

Section: Halogenated Hydrocarbonsmentioning

confidence: 99%

Chemical exposure and hearing loss

Campo¹,

Morata²,

Hong³

2013

Disease-a-Month

124

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Hearing loss following exposure during development to polychlorinated biphenyls: A cochlear site of action

Cited by 89 publications

References 41 publications

Developmental Exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107): Long-Term Effects on Brain Development, Behavior, and Brain Stem Auditory Evoked Potentials in Rats

Developmental Exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107): Long-Term Effects on Brain Development, Behavior, and Brain Stem Auditory Evoked Potentials in Rats

Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex

Chemical exposure and hearing loss

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