Hearing evaluation with ABR in pediatric patients with celiac disease

Yaprak, Neslihan; Sayar, Ersin; Derin, Alper Tunga; Bostancı, Aslı; Turhan, Murat; Yılmaz, Aygen

doi:10.5152/tjg.2020.19510

Cited by 3 publications

(5 citation statements)

References 21 publications

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Section: Discussionmentioning

confidence: 84%

“…A further 3 studies, 17-19 similarly designed, also drew the same conclusions that SNHL and CD show no association, with one of those studies demonstrating objective evidence of no difference by using auditory brainstem responses. 19…”

Section: Discussionmentioning

confidence: 84%

“…15 This conclusion is mirrored by Bükülmez et al 16 with a study with large sample size (97 children with CD and 85 controls) that showed no significant difference in pure tone audiometry, tympanometry, speech audiometry, or OAE between patients with CD and controls. A further 3 studies, [17][18][19] similarly designed, also drew the same conclusions that SNHL and CD show no association, with one of those studies demonstrating objective evidence of no difference by using auditory brainstem responses. 19 Limitations of the above studies are the small sample sizes, different ages of participants, differing methods by which hearing was tested, insufficient long-term follow-up and lack of emphasis on or evaluation of lifestyle or social effects of the hearing impairment.…”

Section: Hearing Lossmentioning

confidence: 92%

“…A further 3 studies, [17][18][19] similarly designed, also drew the same conclusions that SNHL and CD show no association, with one of those studies demonstrating objective evidence of no difference by using auditory brainstem responses. 19 Limitations of the above studies are the small sample sizes, different ages of participants, differing methods by which hearing was tested, insufficient long-term follow-up and lack of emphasis on or evaluation of lifestyle or social effects of the hearing impairment. This topic clearly needs more study and research, but despite the conflicting evidence, it should be noted that the study with the largest sample size (11) showed statistically significant positive association between CD and SNHL.…”

Section: Hearing Lossmentioning

confidence: 92%

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ENT Manifestations of Celiac Disease: A Scholarly Review

Karunaratne

2020

Ear Nose Throat J

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Objectives: Celiac disease is a common multisystemic autoimmune disorder. It is now increasingly recognized that it may present with extraintestinal manifestations which contribute to the difficulty in its diagnosis. The objective of this scholarly review was to examine the extraintestinal ENT manifestations of celiac disease and its pathophysiology and management, in order to highlight that some patients with celiac disease may present initially to the otolaryngologist. Improving awareness of celiac disease among otolaryngologists may aid in the correct diagnosis and correct management plan. Methods: A literature review was conducted using the PubMed database to identify original articles related to celiac disease and ENT manifestations between the years 2000 and 2020. The search was performed using the search string: (“coeliac disease” OR “celiac disease”) AND (“ENT manifestations” OR “hearing loss” OR “epistaxis” OR “nasal septal perforation” OR “obstructive sleep apnoea” OR “vertigo” OR “tonsillitis” OR “sinusitis”). Only articles written in English were reviewed. Results: A total of 17 papers met the inclusion criteria. Extraintestinal ENT manifestations of celiac disease include sensorineural hearing loss, obstructive sleep apnea, nasal septal perforation, epistaxis, and vertigo with nystagmus. Sensorineural hearing loss, obstructive sleep apnea, nasal septal perforation, vertigo, and nystagmus are thought to result from immunologically mediated mechanisms, with intestinal malabsorption resulting in epistaxis. Conclusions: Celiac disease can cause extraintestinal ENT manifestations and requires a high index of suspicion from the otolaryngologist to diagnose and suitably manage. A gluten-free diet may result in sufficient symptom resolution for most manifestations. Sensorineural hearing loss due to celiac disease appears to be progressive and permanent and may require frequent audiological monitoring.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 84%

Section: Hearing Lossmentioning

confidence: 92%

Section: Hearing Lossmentioning

confidence: 92%

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ENT Manifestations of Celiac Disease: A Scholarly Review

Karunaratne

2020

Ear Nose Throat J

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“…On the contrary, Bukulmez et al 13 observed similar hearing functions of children with newly diagnosed CD and healthy controls. Other studies from Urgnaci et al 14 Sahin et al 15 Yazici et al 16 and Yaprak et al 17 did not show significant SNHL in overall measurements of patients with CD compared with controls and hypothesized that subclinical SNHL should be investigated in CD patients for recognizing hearing loss early during the course of the disease.…”

mentioning

confidence: 92%

Immune-Mediated Association Between Celiac Disease and Sensorineural Hearing Loss: A Systematic Narrative Review

Luca

Scarpa

Ralli

et al. 2022

Turk J Gastroenterol

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The auto-immune correlation between sensorineural hearing loss and celiac disease has previously been hypothesized. This review describes available evidence and offers insights for future perspectives. We searched the PubMed database. Studies in the review included children and adults with celiac disease evaluated for hearing loss. Individual case reports and review articles were excluded. The various searches turned in 32 results, of which 10 met the inclusion criteria. Auto-immune hearing loss has been proposed as extraintestinal symptoms of celiac disease, despite the pathogenetic mechanisms being not entirely clear. Several studies postulated that subclinical hearing loss may be present in children with celiac disease. Despite existing literature not clarifying the link between celiac disease and sensorineural hearing loss, some authors proposed hearing screening in younger patients with celiac disease, to prevent the behavioral, cognitive, and sensorimotor impairment of hearing loss. Further rigorous studies are strongly recommended to better explore the relationship between hearing loss and celiac disease.

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Evaluation of Hearing Functions in Children with Celiac Disease and the Effect of Gluten-free Diet on these Functions

Atan,

Comba

2024

Nigerian Journal of Clinical Practice

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Objective: The present study aims to investigate the potential impact of celiac disease (CD) on hearing functions and assess the effect of a gluten-free diet (GFD) on this condition. Materials and Methods: The study included 55 children with CD (110 ears) and 25 healthy controls (50 ears) matched for age and gender. The CD group was divided into adherent (n = 31) and nonadherent (n = 24) to GFD. Participants underwent tympanometry and pure tone audiometry assessments covering frequencies from 500 to 4000 Hz. Results: Patients with CD showed significantly higher air and bone conduction hearing averages compared to the control group at frequencies of 500, 1000, 2000, and 4000 Hz for air conduction, and at 500 Hz for bone conduction (P < 0.05). Celiac patients, those who fully adhered to GFD, had notably higher air conduction hearing averages at 500, 2000, and 4000 Hz compared to healthy controls (P < 0.05). However, there was no difference in bone conduction hearing averages between the two groups. In contrast, celiac patients who did not comply with GFD had statistically significantly higher air and bone conduction hearing averages than the control group (P < 0.05), at frequencies of 500, 1000, and 4000 Hz for air conduction, and at 500 and 1000 Hz for bone conduction (P < 0.05). Conclusions: The study suggests that nonadherence to GFD may elevate the risk of hearing loss in children with CD. As a result, it is recommended to conduct hearing screenings for children with CD and underscore the importance of complying with GFD to mitigate further detrimental effects on hearing functions.

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Hearing evaluation with ABR in pediatric patients with celiac disease

Abstract: Serum resolvin D1 levels as a marker of inflammation in constipation dominant irritable bowel syndrome

Cited by 3 publications

References 21 publications

ENT Manifestations of Celiac Disease: A Scholarly Review

ENT Manifestations of Celiac Disease: A Scholarly Review

Immune-Mediated Association Between Celiac Disease and Sensorineural Hearing Loss: A Systematic Narrative Review

Evaluation of Hearing Functions in Children with Celiac Disease and the Effect of Gluten-free Diet on these Functions

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