Hearing assessment in Egyptian children with chronic renal failure on regular hemodialysis and renal transplantation children

Abstract

Introduction: Hearing impairment is frequent in patients with end-stage renal disease (ESRD). We aimed to assess the prevalence of hearing impairment in children on regular hemodialysis and renal transplantation. Materials and Methods: Transient-evoked otoacoustic emissions (TEOAEs) has been done for 80 children on regular hemodialysis and 40 with renal transplant.Results: In hemodialysis group, TEOAEs showed that 53.8% children had hearing affection, it was significantly related to dialysis duration, dialysis adequacy, vascular access infection, hepatitis C virus (HCV) infection, and ototoxic drugs (p = 0.001, 0.037, 0.011, 0.004, 0.030, 0.007, and 0.044, respectively). In renal transplant group hearing impairment was 25%. There was significant relation with period of dialysis before transplantation and biopsy proved rejection (p = 0.008, <0.001, respectively). Conclusion:Hearing impairment is a common finding in ESRD patients.

Pharmacokinetic–pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells

“…Chronic renal failure (CRF) refers to chronic progressive kidney parenchymal damage caused by a variety of reasons, resulting in irreversible atrophy of the kidneys and impaired metabolic function, which seriously threatens the quality of life of patients (Hameed et al., 2022; Vakilzadeh et al., 2023). Therefore, it is very important to strengthen the prevention and treatment of CRF to delay or prevent further development of the disease course (Fadel et al., 2022). Presently, the traditional Chinese and Western medicine in the treatment of CRF has gradually become a clinical consensus, both of which have common features in the regulation of immunity, prevention and treatment of infection, and anticoagulation (Chen et al., 2022; Fang et al., 2023).…”

“…Chronic renal failure (CRF) refers to chronic progressive kidney parenchymal damage caused by a variety of reasons, resulting in irreversible atrophy of the kidneys and impaired metabolic function, which seriously threatens the quality of life of patients (Hameed et al, 2022;Vakilzadeh et al, 2023). Therefore, it is very important to strengthen the prevention and treatment of CRF to delay or prevent further development of the disease course (Fadel et al, 2022).…”

The role of neuroimmune and inflammation in pediatric uremia-induced neuropathy

“…These abnormalities include microcephaly, retardation, cerebral edema, recurrent seizures and ataxia ( 9 – 11 ). Moreover, children between 3 and 16 years old with chronic renal impairment are more likely to have hearing impairment, decreased hearing sensitivity ( 12 ). Children born by mothers with chronic kidney disease are more likely to develop to cerebral palsy and intellectual disability ( 13 ).…”