Healthy Late-preterm infants born 33–36+6 weeks gestational age have higher risk for respiratory syncytial virus hospitalization

Helfrich, Alison M; Nylund, Cade M.; Eberly, Matthew D.; Eide, M; Stagliano, David

doi:10.1016/j.earlhumdev.2015.06.009

Cited by 50 publications

(47 citation statements)

References 25 publications

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“…Consistent with previous studies [5, 14, 49, 57, 58, 65], recently published data from the ongoing SENTINEL1 study (ClinicalTrials.gov identifier: NCT02273882) [74, 81] demonstrated that earlier gestational age and younger chronologic age were associated with a higher risk of ICU admission and need for mechanical ventilation compared with birth at later gestational age and older chronologic age (Table 3). In this study, data on infants born at 29–35 wGA not receiving RSV immunoprophylaxis were collected from 43 sites across the US [74].…”

Section: Resultssupporting

confidence: 85%

“…RSVH rates for preterm infants over the last two decades vary in the literature [4, 5, 8–12, 29, 31, 37, 47, 49, 51–57], ranging from ~5/1000 children [4] to >100/1000 children [52, 53], with the highest RSVH rates reported in the lowest gestational age infants (Table 1). In the majority of these studies, RSV immunoprophylaxis was not given.…”

Section: Resultsmentioning

confidence: 99%

“…Children with a history of prematurity are at a higher risk of worse hospital outcomes (use of supplemental oxygen, NICU admission) for RSV infection than term infants [5, 8, 12, 14, 24, 46, 49, 50, 57, 58, 64–72, 74, 75]. In the French CASTOR study, preterm infants <33 wGA were prone to more severe disease as suggested by longer hospital stays and the requirement of more therapeutic care, including oxygen therapy and non-mechanical ventilation, compared with the full-term group [50].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Preterm Infants Without Chronic Lung Disease or Congenital Heart Disease

Manzoni

Paes

et al. 2016

Infect Dis Ther

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IntroductionThe REGAL (RSV Evidence—a Geographical Archive of the Literature) series provide a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This second publication covers the risk and burden of RSV infection in preterm infants born at <37 weeks’ gestational age (wGA) without chronic lung disease or congenital heart disease.MethodsA systematic review was undertaken for articles published between January 1, 1995 and December 31, 2015. Studies reporting data for hospital visits/admissions for RSV infection among preterm infants as well as studies reporting RSV-associated morbidity, mortality, and risk factors were included. Study quality and strength of evidence (SOE) were graded using recognized criteria.Results2469 studies were identified of which 85 were included. Preterm infants, particularly those born at lower wGA, tended to have higher RSV hospitalization (RSVH) rates compared with otherwise healthy term infants (high SOE). RSVH rates ranged from ~5 per 1000 children to >100 per 1000 children with the highest rates shown in the lowest gestational age infants (high SOE). Independent risk factors associated with RSVH include: proximity of birth to the RSV season, living with school-age siblings, smoking of mother during pregnancy or infant exposure to environmental smoking, reduced breast feeding, male sex, and familial atopy (asthma) (high SOE). Predictive models can identify 32/33–35 wGA infants at risk of RSVH (high SOE).ConclusionRSV infection remains a major burden on Western healthcare systems and is associated with significant morbidity. Further studies focusing on the prevalence and burden of RSV in different gestational age cohorts, the changing risk of RSVH during the first year of life, and on RSV-related mortality in preterm infants are needed to determine the true burden of disease.FundingAbbVie.Electronic supplementary materialThe online version of this article (doi:10.1007/s40121-016-0130-1) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Preterm Infants Without Chronic Lung Disease or Congenital Heart Disease

Manzoni

Paes

et al. 2016

Infect Dis Ther

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“…The current results are unique in that they provide continuous age-based risk models for outpatient and inpatient disease for infants with and without young child exposure. In addition, the absolute risk estimates are more accurate than those derived from administrative databases with passive case ascertainment [16,17]. …”

Section: Discussionmentioning

confidence: 99%

“…In 2013, Winterstein et al demonstrated that moderate preterm status (32 to 34 wGA) doubled the risk for RSV hospitalization compared to term infants of the same age, and that the risk was highest in the youngest infants [16]. Helfrich et al also identified late preterm birth, defined as 33 weeks to 36 weeks and 6 days, as an independent risk factor for RSV hospitalization, with the greatest risk observed in the first months of life as evidenced by a median age at admission of 3.2 months [17]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Chronologic Age and Young Child Exposure on Respiratory Syncytial Virus Disease among US Preterm Infants Born at 32 to 35 Weeks Gestation

Simões

Anderson

Wu³

et al. 2016

PLoS ONE

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ObjectiveTo estimate the incidence of respiratory syncytial virus (RSV) disease as a function of chronologic age and exposure to young children in US preterm infants.MethodsIn the RSV Respiratory Events among Preterm Infants Outcomes and Risk Tracking (REPORT) study, preterm infants born at 32–35 weeks gestational age (wGA) were enrolled from 188 US clinics and followed September-May of 2009–2010 or 2010–2011. Infants with medically-attended acute respiratory illness had nasal/pharyngeal swabs collected for viral testing. Results of RSV tests conducted during routine clinical care were also collected. Event rates during November-March were modeled as a function of chronologic age and birth month using Poisson regression and adjusting for other covariates. Rates were calculated overall and for infants with and without exposure to young siblings or daycare attendance. Of 3317 infants screened, 1646 were enrolled as a consecutive sample. Infants with chronic lung disease of prematurity, hemodynamically significant congenital heart disease, life expectancy <6 months, or receiving or being considered for RSV immunoprophylaxis were excluded. 84% of patients completed the study. Demographics of the enrolled cohort were generally similar to those of US infants born at 32–35 wGA; infants 32–34 wGA, Hispanic infants, and infants of less-educated mothers were under-represented.ResultsAmong 1642 evaluable infants, outpatient RSV lower respiratory illness incidence was highest at older ages, whereas RSV hospitalization and intensive care unit (ICU) admission were highest at younger ages. In all instances, young child exposure was associated with higher RSV incidence. The highest RSV hospitalization and ICU rates occurred among February-born infants with young child exposure, at 19.0 (95% CI, 13.5–27.0) and 6.5 (95% CI, 5.6–7.6) per 100 infant-seasons, respectively.ConclusionsPreterm infants have a substantially elevated risk of RSV disease. Young age and exposure to other young children identify those at greatest risk of severe RSV disease.Trial RegistrationClinicaltrials.gov: NCT00983606.

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Hospital admissions for lower respiratory tract infections in children born moderately/late preterm

Haataja

Korhonen

Ojala

et al. 2017

Pediatric Pulmonology

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Healthy Late-preterm infants born 33–36+6 weeks gestational age have higher risk for respiratory syncytial virus hospitalization

Cited by 50 publications

References 25 publications

Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Preterm Infants Without Chronic Lung Disease or Congenital Heart Disease

Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Preterm Infants Without Chronic Lung Disease or Congenital Heart Disease

Effects of Chronologic Age and Young Child Exposure on Respiratory Syncytial Virus Disease among US Preterm Infants Born at 32 to 35 Weeks Gestation

Hospital admissions for lower respiratory tract infections in children born moderately/late preterm

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