Healthy Gut, Healthy Bones: Targeting the Gut Microbiome to Promote Bone Health

Cooney, Olivia D.; Nagareddy, Prabhakar R.; Murphy, Andrew; Lee, Man K.S.

doi:10.3389/fendo.2020.620466

Cited by 33 publications

(28 citation statements)

References 63 publications

(64 reference statements)

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“…The results of L. I. Sidorchuk & A. S. Sidorchuk (2018) also suggest the development of intestinal absorption disorders in experimental animals with hypothyroidism due to reduced colonization resistance of the colonic mucosa, the development of dysbiosis, and contamination and colonization of the epithelial biofilm by mucosal microorganisms (Pacifici, 2021). Insufficient supply of calcium in the bloodstream after its absorption triggers the mechanism of bone resorption with the participation of parathyroid hormone (Cooney et al, 2021), as shown by our studies of bone tissue of rats with hypothyroidism Our assumption that the reason for the decrease in the absorption of calcium in the small intestine in hypothyroidism may be induced by mercazolyl pathological processes not only in the intestine but also in the entire digestive tract was confirmed by the biochemical studies of gums and gastric mucosa, small and large intestines. We found the development of oxidative stress, inflammatory and dysbiotic processes against the background of reduced antimicrobial and antioxidant protection in the mouth, stomach and intestines of animals with experimental hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of using a complex of minerals and vitamins for prevention of complications in bone tissue and the digestive tract in rats with hypothyroidism

Макаренко

Zaderei

Maikova

2021

Regul. Mech. Biosyst.

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Significant consequences of hypothyroidism are impairments in all types of metabolism, including bone metabolism, pathological changes in the digestive tract and the development of deficiency of vitamins, macro-and micronutrients.The relevance of the study is due to the widespread occurrence of hypothyroidism and the feasibility of developing effective methods for the prevention of the pathology and its complications. The study was aimed at the condition of bone tissue and digestive tract in rats with hypothyroidism, as well as the effectiveness of preventive addition of a complex of vitamins and minerals. The studies were performed on rats with hypothyroidism that was caused using thyrostatic mercazolyl for 50 days, administered orally. Prophylaxis was performed by adding a prophylactic complex of vitamins P, C, D and minerals Ca, Mg, Cu, Se, Mn to the daily diet. In the bone tissue of rats, the indicators of destruction (elastase and acid phosphatase activity) and mineralization (alkaline phosphatase activity, calcium content) as well as the antioxidant state (activities of catalase, glutathione reductase, malonic dialdehyde content) were studied. In the gums and mucous membranes of the digestive tract of rats, we determined indicators of antioxidant status (catalase activity, malonic dialdehydecontent), inflammation (activities of elastase, acid phosphatase) and dysbiosis (activities of urease activity, lysozyme). In the bone tissue of rats with hypothyroidism, activation of destruction processes, reduction of calcium levels, activation of lipid peroxidation and antioxidant enzymes were found. Hypothyroidism also led to pathological disorders in the gums of rats and gastric mucosa, small and large intestine, namely – the development of inflammation, increased membrane permeability, activation of lipid peroxidation, increased contamination with opportunistic bacteria against the background of reduced antioxidant protection. In general, preventive use of the complex contributed to the normalization of the studied parameters in the gums, mucous membranes of the stomach, intestines, as well as remodeling processes and antioxidant-prooxidative state in the bone tissue of animals with hypothyroidism. In the conditions of hypothyroidism, the proposed complex of vitamins and minerals provided notable antioxidant, anti-inflammatory and antidysbiotic effects in the tissues of the gastrointestinal tract, thus overcoming the calcium deficiency in the blood and stopping the destructive and oxidative processes in the bone tissue of animals with hypothyroidism.

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Section: Discussionmentioning

confidence: 99%

Efficacy of using a complex of minerals and vitamins for prevention of complications in bone tissue and the digestive tract in rats with hypothyroidism

Макаренко

Zaderei

Maikova

2021

Regul. Mech. Biosyst.

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“…SCFAs produced by intestinal ora through fermenting dietary bers have the ability to inhibit bone resorption without affecting bone formation [10]. Additionally, intestinal microbes can regulate the differentiation and apoptosis of osteoclast by controlling the dynamic balance of Th-17/Treg cell [11,12].…”

Section: Discussionmentioning

confidence: 99%

A Patient With Turner Syndrome Recieved the Percutaneous Vertebroplasty Seven Times: a Case Report and Literature Review

Li¹,

Shi²,

Zhao³

et al. 2021

Preprint

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Background Turner syndrome (TS) is characterized as the complete or partial absence of one X chromosome and is an extremely rare disease affecting approximately 1:2,500 live female births. Though the prevalence of osteoporosis among women with TS is estimated to be around 55-64% and they suffer more frequently from fractures than normal, few reports concerning TS patients with osteoporosis are able to be seen due to tiny number of patients. Case presentation Here we report a rare case of TS with osteoporosis, who has undergone percutaneous vertebroplasty (PVP) seven times because of several vertebral compression fractures (VCFs). G-banded karyotype analysis was performed and the result was 45,X[43]/47,XXX[17], indicating that the patient was a mosaicism of TS karyotype and Trisomy X syndrome karyotype. TS is the underlying cause of low level of estrogen for this patient. The interaction of aging, estrogen deficiency and intestinal dysbacteriosis leads to her severe osteoporosis and multi-segmental VCFs. The aim of this report is to provide recommendations regarding the management of TS patients with osteoporosis by reviewing the clinical presentation of TS, the influence of estrogen deficiency in osteoporosis, etc.Conclusions Early diagnosis and hormone replacement treatment are essential to prevent osteoporosis and reduce the risk of fractures. This is a rare case report describing TS patient with severe osteoporosis and VCFs.

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“…SCFAs produced by intestinal flora through fermenting dietary fibers have the ability to inhibit bone resorption without affecting bone formation [ 10 ]. Additionally, intestinal microbes can regulate the differentiation and apoptosis of osteoclast by controlling the dynamic balance of Th-17/T-reg cell [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

A patient with Turner syndrome received the percutaneous vertebroplasty seven times: a case report and literature review

Shi

Zhao

et al. 2021

Eur J Med Res

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Background Turner syndrome (TS) is characterized as the complete or partial absence of one X chromosome and is an extremely rare disease affecting approximately 1:2500 live female births. Though the prevalence of osteoporosis among women with TS is estimated to be around 55–64% and they suffer more frequently from fractures than normal, few reports concerning TS patients with osteoporosis are able to be seen due to tiny number of patients. Case presentation Here, we report a rare case of TS with osteoporosis, who has undergone percutaneous vertebroplasty (PVP) seven times because of several vertebral compression fractures (VCFs). G-banded karyotype analysis was performed and the result was 45,X[43]/47,XXX[17], indicating that the patient was a mosaicism of TS karyotype and Trisomy X syndrome karyotype. TS is the underlying cause of low level of estrogen for this patient. The interaction of aging, estrogen deficiency and intestinal dysbacteriosis leads to her severe osteoporosis and multi-segmental VCFs. The aim of this report is to provide recommendations regarding the management of TS patients with osteoporosis by reviewing the clinical presentation of TS, the influence of estrogen deficiency in osteoporosis, etc. Conclusions Early diagnosis and hormone replacement treatment are essential for TS patients to prevent osteoporosis and reduce the risk of fractures. This is a rare case report describing TS patient with severe osteoporosis and VCFs.

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Healthy Gut, Healthy Bones: Targeting the Gut Microbiome to Promote Bone Health

Cited by 33 publications

References 63 publications

Efficacy of using a complex of minerals and vitamins for prevention of complications in bone tissue and the digestive tract in rats with hypothyroidism

Efficacy of using a complex of minerals and vitamins for prevention of complications in bone tissue and the digestive tract in rats with hypothyroidism

A Patient With Turner Syndrome Recieved the Percutaneous Vertebroplasty Seven Times: a Case Report and Literature Review

A patient with Turner syndrome received the percutaneous vertebroplasty seven times: a case report and literature review

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