Healthy donor effect: its magnitude in health research among blood donors

Atsma, Femke; Veldhuizen, I.J.T.; Verbeek, A.L.M.; Kort, Wim de; Vegt, Femmie de

doi:10.1111/j.1537-2995.2010.03055.x

Cited by 113 publications

(132 citation statements)

References 29 publications

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“…Furthermore, it is important to keep in mind that the donor population is a relatively healthy sample of the Dutch population and that the Dutch climate is temperate. 37 Our results may therefore not apply to individuals ineligible or unwilling to donate blood. Nonetheless, our reported associations increased in strength at higher temperatures and at older age.…”

Section: Discussionmentioning

confidence: 88%

Higher outdoor temperatures are progressively associated with lower blood pressure: a longitudinal study in 100,000 healthy individuals

Hurk

Kort

Deinum

et al. 2015

Journal of the American Society of Hypertension

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Section: Discussionmentioning

confidence: 88%

Higher outdoor temperatures are progressively associated with lower blood pressure: a longitudinal study in 100,000 healthy individuals

Hurk

Kort

Deinum

et al. 2015

Journal of the American Society of Hypertension

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“…As a result, donors are composed of a relatively healthy group of individuals. 13,14 In addition, the huge amount of prospectively collected donation data measured before each blood donation, including Hb levels and blood pressure, enabled us to precisely assess the strength of the association between Hb levels and blood pressure in healthy persons.…”

mentioning

confidence: 99%

Hemoglobin Level Is Positively Associated With Blood Pressure in a Large Cohort of Healthy Individuals

Atsma

Veldhuizen²,

Kort³

et al. 2012

Hypertension

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Abstract-It has been hypothesized that an increased hemoglobin level elevates blood pressure. The present study investigated the association between hemoglobin level and systolic blood pressure and diastolic blood pressure in healthy persons. The study population was composed of 101 377 whole blood and plasma donors, who made 691 107 visits to the blood bank. At each visit, hemoglobin level and blood pressure were measured as part of the standard procedure before a blood donation. We used repeated measurement analysis to analyze the data. We used generalized estimating equation models to assess the between-person effect and linear mixed models to assess the within-person effect. All of the analyses were done separately for men and women. In the study population, 50% were men. The mean age in men was 49.3 years (±12.5 years), and in women it was 42.4 years (±13.7 years). Hemoglobin level was positively associated with both systolic and diastolic blood pressures. With respect to the between-person effect, regression coefficients for systolic blood pressure were 1.3 mm Hg per millimole per liter increase in hemoglobin level for men and 1.8 mm Hg per millimole per liter increase in hemoglobin level for women. With respect to the within-person effect, regression coefficients for systolic blood pressure were 0.7 mm Hg and 0.9 mm Hg per millimole per liter increase in hemoglobin level, for men and women, respectively. For diastolic blood pressure, results were comparable. The results show that hemoglobin level is positively associated with both systolic and diastolic blood pressures in healthy individuals. We observed consistent effects between persons but also within persons.

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“…One large limitation of our research is that the results describe an association but not a causal mechanism [84,85]. Adult parents who voluntarily think about organ donation are not a random sample of society and, instead, differ in many ways from the general population [86][87][88][89][90]6,91]. These unmeasured differences are not isolated to organ donation and likely correlate with other knowledge, attitudes, and behaviors shared among family members that contribute to health protection and injury prevention [92][93][94][95][96].…”

Section: Discussionmentioning

confidence: 97%