Healthcare Costs of Rotavirus and Other Types of Gastroenteritis in Children in Norway

Shin, Minkyung; Salamanca, Beatriz Valcárcel; Kristiansen, Ivar Sønbø; Flem, Elmira

doi:10.1097/inf.0000000000001026

Cited by 9 publications

(12 citation statements)

References 24 publications

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“…In the vaccination strategy, we added the costs of the vaccination programme, including the vaccine itself, and also implementation, administration and storage costs. To compute the costs of primary care consultations more accurately, we differentiated between primary care consultation at emergency outpatient clinics (EOCs) and general practitioner (GP) offices based on proportions reported by Shin et al [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

“…The incidence of hospitalisation due to RVGE was estimated at three cases per 1000 children below 5 years of age [ 8 ], while the incidence of primary care consultations and homecare disease episodes was derived from the hospitalisation estimates. Since 2009, new and improved studies have assessed the health [ 9 ] and economic [ 10 ] burden of rotavirus in the primary and secondary healthcare sectors in Norway. These studies reported a higher incidence of rotavirus–associated primary care consultations (30.6 per 1000 children) and hospitalisations (6.3 per 1000 children) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Re–evaluation of the cost–effectiveness and effects of childhood rotavirus vaccination in Norway

et al. 2017

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BackgroundRotavirus vaccination was included into the Norwegian childhood immunisation programme in 2014. Before implementation, rotavirus vaccination was found to be cost–effective from a societal perspective, but not from a healthcare perspective. Since introduction, new data on the incidence and economic effects of rotavirus disease have become available. We assessed early epidemiological effects of the rotavirus vaccination programme and re–evaluated its cost–effectiveness in Norway for the years 2015–2019.MethodsUsing a dynamic transmission model, we compared the epidemiological effects of the ongoing two–dose vaccination programme with Rotarix®, and a hypothetical 3–dose programme with RotaTeq® with no vaccination. A baseline cost of € 54 per fully vaccinated child was used. Cost–effectiveness was computed from a healthcare and societal perspective, using a decision analytical model. Data on healthcare use and costs, productivity losses and health utilities were based on published and own estimates. Uncertainty was accounted for in one–way, multi–way, and probabilistic sensitivity analyses.ResultsDuring 2015–2019, 114,658 home care cases, 34,571 primary care cases, 7,381 severe cases, and 2 deaths associated with rotavirus disease were avoided due to vaccination. Under baseline assumptions vaccination was cost–effective from a healthcare perspective with a cost per QALY of € 47,447 for Rotarix® and € 52,709 for RotaTeq®. The break–even price was € 70 for Rotarix® and € 67 for RotaTeq®. Vaccination was cost–saving from the societal perspective, and also from a healthcare perspective for vaccine prices below € 25 and € 22 per vaccinated child for Rotarix® and RotaTeq®, respectively.ConclusionOngoing childhood rotavirus vaccination in Norway has reduced the rotavirus disease burden substantially, and is cost–effective compared with no vaccination.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Re–evaluation of the cost–effectiveness and effects of childhood rotavirus vaccination in Norway

et al. 2017

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“…Vi har ikke tilsvarende undersøkelser av rotavirusinfeksjoner i allmennpraksis, men det er gjort flere kartlegginger av gastroenteritt, oppkast og diaré, basert på regningskort fra fastleger og legevaktleger (3)(4)(5). Gastroenteritt er årsak til 3,6 % av alle konsultasjoner med barn under fem år (5).…”

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“…Gastroenteritt er årsak til 3,6 % av alle konsultasjoner med barn under fem år (5). De fordeler seg med 28-30 % på legevakt og resten hos fastlege (3)(4)(5). Før innføring av rotavirusvaksine ble det beregnet at omtrent 30 % av tilfellene skyldtes rotavirus (1,2).…”

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Barn på legevakt med gastroenteritt før og etter innføring av rotavirusvaksinen

Sandvik¹

2020

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Nasjonalt kompetansesenter for legevaktmedisin NORCE Norwegian Research Centre og Morvik legekontor Bergen Hogne Sandvik er dr.med., spesialist i allmennmedisin, forsker og fastlege. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. BAKGRUNN Rotavirus er den hyppigste årsaken til alvorlig diaré hos små barn. Hensikten med denne studien var å kartlegge legevaktkonsultasjoner på grunn av gastroenteritt hos små barn før og etter innføring av rotavirusvaksine 1. oktober 2014. MATERIALE OG METODE Materialet består av data fra alle elektroniske regningskort fra legevaktleger i perioden 2010-18. Det ble beregnet kvartalsvise konsultasjonsrater på legevakt for barn i alderen 0-4 år på grunn av gastroenteritt. Konsultasjonsrate-ratio for årene 2015-18 ble beregnet ved å dividere konsultasjonsraten med tilsvarende gjennomsnitt for årene 2010-13. RESULTATER Konsultasjonsraten var høyest i første kvartal. I årene 2010-13 (før innføring av vaksine) hadde spedbarna en gjennomsnittlig konsultasjonsrate på 9,7 per 1 000 innbyggere, ettåringene 14,3 og toåringene 7,3. I 2016 (etter innføring av vaksine) var konsultasjonsrateratio i første kvartal 0,5 for spedbarna, 0,3 for ettåringene og 0,4 for toåringene. I 2017 og 2018 var tilsvarende konsultasjonsrate-ratio 0,5 for spedbarna, 0,4 for ettåringene og 0,5 for toåringene. Tre-og fireåringer hadde lavere konsultasjonsrater og mindre endringer over tid. FORTOLKNING Den sterke nedgangen i konsultasjonsrater på grunn av gastroenteritt kan ha sammenheng med innføring av rotavirusvaksine i barnevaksinasjonsprogrammet.

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“…The high frequency of development of severe forms of rotavirus gastroenteritis in young children, the difficulties in treating patients, and the negative consequences of the disease (imbalance of the gut microbiota, decreased immune forces of the body, etc.) determine the relevance of this pathology [4,15]. In recent years, the interest of scientists has been attracted by the problem of immunopathogenesis of intestinal infections, including rotavirus etiology, various exogenous and endogenous factors that can change the immune response of patients and, as a result, the clinical manifestations of the disease and its course [3,6,7].…”

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Clinical and Immunological Features of Rotavirus Gastroenteritis in Children Infected With Herpes Viruses

Kuznecov

Sliepchenko

2019

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The article presents the results of a comparative analysis of clinical and immunological parameters in children with rotavirus gastroenteritis without background infection and those infected by herpes viruses. It was established that in children with rotavirus infection (RVI) on the background of infection by herpes viruses occurs with less pronounced symptoms of intoxication and a less frequency of vomiting at the onset of the disease, in combination with longer duration (more long period) of fever and diarrheal syndrome. Such features are probably associated with the formation of a hypergical regime of the functioning of the immune response in the group of patients with background infection by herpes viruses, in contrast to patients with mono- RVI, in whom the immune system functions in a normal compensation mode.

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Healthcare Costs of Rotavirus and Other Types of Gastroenteritis in Children in Norway

Abstract: Healthcare costs of rotavirus gastroenteritis in Norway are substantial. The cost-effectiveness of ongoing rotavirus immunization program should be reassessed.

Cited by 9 publications

References 24 publications

Re–evaluation of the cost–effectiveness and effects of childhood rotavirus vaccination in Norway

Re–evaluation of the cost–effectiveness and effects of childhood rotavirus vaccination in Norway

Barn på legevakt med gastroenteritt før og etter innføring av rotavirusvaksinen

Clinical and Immunological Features of Rotavirus Gastroenteritis in Children Infected With Herpes Viruses

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